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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

metabolic product

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (1) AMPK (1) Antibiotic (2) Apoptosis (10) Autophagy (7) Bacterial (6) Biochemical Assay Reagents (3) Casein Kinase (1) Cholinesterase (ChE) (1) COMT (1) COX (2) Cuproptosis (2) Dopamine Receptor (1) Drug Metabolite (5) Endogenous Metabolite (40) Epoxide Hydrolase (1) Ferroptosis (3) Fungal (1) HBV (1) HDAC (2) HIV (2) HSV (1) iGluR (2) Influenza Virus (1) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) mAChR (1) mGluR (1) Mitophagy (2) MMP (1) Necroptosis (1) Notch (2) Nucleoside Antimetabolite/Analog (1) Organoid (2) Oxidative Phosphorylation (2) P2Y Receptor (1) Prostaglandin Receptor (1) Proton Pump (1) Reactive Oxygen Species (2) SARS-CoV (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (6) Endocrinology (2) Infection (8) Inflammation/Immunology (15) Metabolic Disease (30) Neurological Disease (14)

By Targets:

11β-HSD (1)

5-HT Receptor (1)

AMPK (1)

Antibiotic (2)

Apoptosis (10)

Autophagy (7)

Bacterial (6)

Biochemical Assay Reagents (3)

Casein Kinase (1)

Cholinesterase (ChE) (1)

COMT (1)

COX (2)

Cuproptosis (2)

Dopamine Receptor (1)

Drug Metabolite (5)

Endogenous Metabolite (40)

Epoxide Hydrolase (1)

Ferroptosis (3)

Fungal (1)

HBV (1)

HDAC (2)

HIV (2)

HSV (1)

iGluR (2)

Influenza Virus (1)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (1)

mAChR (1)

mGluR (1)

Mitophagy (2)

MMP (1)

Necroptosis (1)

Notch (2)

Nucleoside Antimetabolite/Analog (1)

Organoid (2)

Oxidative Phosphorylation (2)

P2Y Receptor (1)

Prostaglandin Receptor (1)

Proton Pump (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

Transthyretin (TTR) (1)

By Research Areas:

Cancer (29)

Cardiovascular Disease (6)

Endocrinology (2)

Infection (8)

Inflammation/Immunology (15)

Metabolic Disease (30)

Neurological Disease (14)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0418

Dulcite Dulcitol; Melampyrit; NSC 1944	Endogenous Metabolite	Others
Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galactose.

HY-107850

Pregnanediol NSC 1612; NSC 47462	Endogenous Metabolite	Metabolic Disease
Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-113284

Succinyladenosine N6-Succinyl adenosine	Endogenous Metabolite	Metabolic Disease
Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency .

HY-N10216

Cynodontin	Others	Infection
Cynodontin is a metabolic product of Helminthosporium cynodontis Marignoni and Helminthosporium euchlaenae Zimmermann .

HY-Y0418R

Dulcite (Standard)	Endogenous Metabolite	Others
Dulcite (Standard) is the analytical standard of Dulcite. This product is intended for research and analytical applications. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galactose.

HY-113043

Galactonic acid	Endogenous Metabolite	Others
Galactonic acid is a sugar acid that is a metabolic breakdown product of galactose. Galactose dehydrogenase is responsible for converting galactose to galactonolactone, which then spontaneously or enzymatically converts to galactonic acid .

HY-Y0418S

Dulcite-13C Dulcitol-¹³C; Melampyrit-¹³C; NSC 1944-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite- ¹³C is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-Y0418S4

Dulcite-d2 Dulcitol-d₂; Melampyrit-d₂; NSC 1944-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite-d₂ is the deuterium labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-N0680R

Thiamine hydrochloride (Standard) Thiamine chloride hydrochloride (Standard); Vitamin B1 hydrochloride (Standard)	Bacterial Endogenous Metabolite HBV Apoptosis	Neurological Disease
Thiamine (hydrochloride) (Standard) is the analytical standard of Thiamine (hydrochloride). This product is intended for research and analytical applications. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes .

HY-N0130R

Shikimic acid (Standard)	Endogenous Metabolite	Others
Shikimic acid (Standard) is the analytical standard of Shikimic acid. This product is intended for research and analytical applications. Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.

HY-W010735R

ATP disodium salt hydrate (Standard)	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
ATP (disodium salt hydrate) (Standard) is the analytical standard of ATP (disodium salt hydrate). This product is intended for research and analytical applications. ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation .

HY-Y0418S1

Dulcite-13C-1 Dulcitol-¹³C-1; Melampyrit-¹³C-1; NSC 1944-¹³C-1	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite- ¹³C-1 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-Y0418S2

Dulcite-13C-2 Dulcitol-¹³C-2; Melampyrit-¹³C-2; NSC 1944-¹³C-2	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite- ¹³C-2 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-Y0418S3

Dulcite-13C-3 Dulcitol-¹³C-3; Melampyrit-¹³C-3; NSC 1944-¹³C-3	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite- ¹³C-3 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-N12528

10,11-EDT	Epoxide Hydrolase	Cardiovascular Disease
10,11-EDT, a soluble epoxide hydrolase (sEH) substrate, is a metabolic product of adrenic acid. 10,11-EDT is an endothelium-derived hyperpolarizing factor with strong vasorelaxant effects .

HY-W017443R

L-Asparagine monohydrate (Standard)	Endogenous Metabolite	Metabolic Disease
L-Asparagine (monohydrate) (Standard) is the analytical standard of L-Asparagine (monohydrate). This product is intended for research and analytical applications. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-D0195R

Acesulfame potassium (Standard)	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
Acesulfame (potassium) (Standard) is the analytical standard of Acesulfame (potassium). This product is intended for research and analytical applications. Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice .

HY-N12033

4'-Demethylpodophyllotoxone	Others	Cancer
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-B0863R

Glyphosate (Standard)	Apoptosis Autophagy Necroptosis	Cancer
Glyphosate (Standard) is the analytical standard of Glyphosate. This product is intended for research and analytical applications. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-W012499R

N-Acetyl-L-methionine (Standard)	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-methionine (Standard) is the analytical standard of N-Acetyl-L-methionine. This product is intended for research and analytical applications. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development .

HY-123284

LY137150	Others	Others
LY137150 (2) and LY163252 (4) are products of LY175326 metabolism in rats or dogs. The preparation of LY175326 labeled with 14C at the methylthiol group provides a sensitive method to determine whether the metabolically produced LY137150 (2) is further metabolized by S-demethylation.

HY-Y1314R

Dimethyl sulfone (Standard)	Drug Metabolite Endogenous Metabolite	Metabolic Disease
Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B1779R

Sucrose (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
Sucrose (Standard) is the analytical standard of Sucrose. This product is intended for research and analytical applications. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .

HY-136386R

N-Acetyl-D-cysteine (Standard)	Reactive Oxygen Species	Others
N-Acetyl-D-cysteine (Standard) is the analytical standard of N-Acetyl-D-cysteine. This product is intended for research and analytical applications. N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .

HY-Y1314

Dimethyl sulfone 1 Publications Verification	Drug Metabolite Endogenous Metabolite	Metabolic Disease
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-W041195S

3-Hydroxy-3-methylhexanoic acid-d5	Isotope-Labeled Compounds	Others
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .

HY-B0300R

Penicillamine (Standard)	Cuproptosis Drug Metabolite	Inflammation/Immunology Cancer
Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-N8519

Urdamycin B	Bacterial Fungal Antibiotic	Infection Cancer
Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .

HY-N0390R

L-Glutamine (standard) 10+ Cited Publications	mGluR Endogenous Metabolite Ferroptosis	Metabolic Disease Cancer
L-Glutamine (Standard) is the analytical standard of L-Glutamine. This product is intended for research and analytical applications. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .

HY-101036R

Choline bitartrate (Standard)	mAChR Endogenous Metabolite	Neurological Disease Cancer
Choline (bitartrate) (Standard) is the analytical standard of Choline (bitartrate). This product is intended for research and analytical applications. Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders . Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism .

HY-162836

Rifamycin B 4-O-(Carboxymethyl)-Rifamycin	Antibiotic Bacterial	Infection
Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a *metabolic* product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation .

HY-131490

Tetrazolium violet Violet tetrazolium	Biochemical Assay Reagents	Others
Tetrazolium violet is a redox indicator commonly used in various biochemical assays to measure cell viability and metabolic activity. Tetrazolium Violet has unique chemical properties that allow it to be reduced by cellular enzymes such as dehydrogenases to form a purple formazan product that can be detected spectrophotometrically. This makes it a useful tool for assessing cell health and growth in culture or tissue samples.

HY-N0304R

L-DOPA (Standard) Levodopa (Standard); 3,4-Dihydroxyphenylalanine (Standard)	Dopamine Receptor Endogenous Metabolite	Neurological Disease Cancer
L-DOPA (Standard) is the analytical standard of L-DOPA. This product is intended for research and analytical applications. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .

HY-B0456R

Riboflavin (Standard)	Endogenous Metabolite Bacterial	Metabolic Disease Cancer
Riboflavin (Standard) is the analytical standard of Riboflavin. This product is intended for research and analytical applications. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .

HY-B0389R

D-Glucose (Standard)	Endogenous Metabolite	Cardiovascular Disease Others Metabolic Disease Endocrinology Cancer
D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-N0035R

Arctigenin (Standard)	MMP Influenza Virus Autophagy Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-W003371R

CGP 44 645 (Standard)	Drug Metabolite	Others
CGP 44 645 (Standard) is the analytical standard of CGP 44 645. This product is intended for research and analytical applications. CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific .

HY-W013093R

Uridine triphosphate trisodium salt (Standard)	Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Uridine triphosphate (trisodium salt) (Standard) is the analytical standard of Uridine triphosphate (trisodium salt). This product is intended for research and analytical applications. Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors .

HY-B0300

Penicillamine 2 Publications Verification D-(-)-Penicillamine	Cuproptosis Drug Metabolite	Inflammation/Immunology Cancer
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-B0227R

Ketoprofen (Standard) RP-19583 (Standard)	COX	Metabolic Disease Inflammation/Immunology Cancer
Ketoprofen (Standard) is the analytical standard of Ketoprofen. This product is intended for research and analytical applications. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC₅₀ values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .

HY-W013136R

Triheptanoin (Standard)	Others	Neurological Disease
Triheptanoin (Standard) is the analytical standard of Triheptanoin. This product is intended for research and analytical applications. Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders .

HY-19528R

SAH (Standard)	Endogenous Metabolite	Metabolic Disease
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-120425R

Ethiprole (Standard)	Others	Infection
Ethiprole (Standard) is the analytical standard of Ethiprole. This product is intended for research and analytical applications. Ethiprole is an insecticide.Metabolic sulfones are produced faster than Fipronil (HY-B0822) in CYP3A4-expressing cells and in vivo in mouse brain and liver.Ethiprole's sulfide, sulfoxide, sulfone and desulfinyl derivatives have better biological activity .

HY-N4170

Chebulic acid 1 Publications Verification	Keap1-Nrf2 Reactive Oxygen Species	Metabolic Disease
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N11286R

Tridocosahexaenoylglycerol (Standard)	Others	Neurological Disease Metabolic Disease Inflammation/Immunology
Tridocosahexaenoylglycerol (Standard) is the analytical standard of Tridocosahexaenoylglycerol. This product is intended for research and analytical applications. Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-128428R

Carboprost (Standard)	Prostaglandin Receptor	Endocrinology
Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-113439

12-HETE	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-W009538R

5-Fluoro-5'-deoxycytidine (Standard)	Nucleoside Antimetabolite/Analog	Cancer
5-Fluoro-5'-deoxycytidine (Standard) is the analytical standard of 5-Fluoro-5'-deoxycytidine. This product is intended for research and analytical applications. 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-113365

Cholestenone 4-Cholesten-3-one	Endogenous Metabolite	Infection Metabolic Disease
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .

HY-W047710

D-Galactal	Biochemical Assay Reagents	Others
D-Galactal is a monosaccharide that belongs to the class of carbohydrates. It is an aldohexose, which means it has six carbon atoms and an aldehyde functional group. D-Galactal occurs naturally in certain foods such as dairy products, meats and fruits. It can also be synthesized by chemical or enzymatic processes. D-Galactal has various applications in the food industry, especially as a flavoring and sweetening agent. Additionally, it has potential research roles in metabolic disorders, cancer, and inflammation.

Cat. No.	Product Name

HY-L012

Metabolism/Protease Compound Library

4,707 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4,707 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

HY-L123

Human Metabolite Library

6,190 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,190 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Cat. No.	Product Name	Type

HY-131490

Tetrazolium violet

Violet tetrazolium

Indicators

Tetrazolium violet is a redox indicator commonly used in various biochemical assays to measure cell viability and metabolic activity. Tetrazolium Violet has unique chemical properties that allow it to be reduced by cellular enzymes such as dehydrogenases to form a purple formazan product that can be detected spectrophotometrically. This makes it a useful tool for assessing cell health and growth in culture or tissue samples.

HY-W047710

D-Galactal

Carbohydrates

D-Galactal is a monosaccharide that belongs to the class of carbohydrates. It is an aldohexose, which means it has six carbon atoms and an aldehyde functional group. D-Galactal occurs naturally in certain foods such as dairy products, meats and fruits. It can also be synthesized by chemical or enzymatic processes. D-Galactal has various applications in the food industry, especially as a flavoring and sweetening agent. Additionally, it has potential research roles in metabolic disorders, cancer, and inflammation.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0418

Dulcite Dulcitol; Melampyrit; NSC 1944	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galactose.

HY-107850

Pregnanediol NSC 1612; NSC 47462	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-113284

Succinyladenosine N6-Succinyl adenosine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency .

HY-N10216

Cynodontin	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Others
Cynodontin is a metabolic product of Helminthosporium cynodontis Marignoni and Helminthosporium euchlaenae Zimmermann .

HY-Y0418R

Dulcite (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
Dulcite (Standard) is the analytical standard of Dulcite. This product is intended for research and analytical applications. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galactose.

HY-113043

Galactonic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Galactonic acid is a sugar acid that is a metabolic breakdown product of galactose. Galactose dehydrogenase is responsible for converting galactose to galactonolactone, which then spontaneously or enzymatically converts to galactonic acid .

HY-N0680R

Thiamine hydrochloride (Standard) Thiamine chloride hydrochloride (Standard); Vitamin B1 hydrochloride (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Bacterial Endogenous Metabolite HBV Apoptosis
Thiamine (hydrochloride) (Standard) is the analytical standard of Thiamine (hydrochloride). This product is intended for research and analytical applications. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes .

HY-N0130R

Shikimic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Plants Acacia confusa Merr. Compositae Endogenous metabolite	Endogenous Metabolite
Shikimic acid (Standard) is the analytical standard of Shikimic acid. This product is intended for research and analytical applications. Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.

HY-W010735R

ATP disodium salt hydrate (Standard)	Structural Classification Microorganisms other families Animals Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Endogenous Metabolite
ATP (disodium salt hydrate) (Standard) is the analytical standard of ATP (disodium salt hydrate). This product is intended for research and analytical applications. ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation .

HY-N12528

10,11-EDT	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Epoxide Hydrolase
10,11-EDT, a soluble epoxide hydrolase (sEH) substrate, is a metabolic product of adrenic acid. 10,11-EDT is an endothelium-derived hyperpolarizing factor with strong vasorelaxant effects .

HY-W017443R

L-Asparagine monohydrate (Standard)	Structural Classification Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Asparagine (monohydrate) (Standard) is the analytical standard of L-Asparagine (monohydrate). This product is intended for research and analytical applications. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N12033

4'-Demethylpodophyllotoxone	Structural Classification Source classification Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae	Others
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-B0863R

Glyphosate (Standard)	Microorganisms Source classification	Apoptosis Autophagy Necroptosis
Glyphosate (Standard) is the analytical standard of Glyphosate. This product is intended for research and analytical applications. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-W012499R

N-Acetyl-L-methionine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
N-Acetyl-L-methionine (Standard) is the analytical standard of N-Acetyl-L-methionine. This product is intended for research and analytical applications. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development .

HY-Y1314R

Dimethyl sulfone (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Drug Metabolite Endogenous Metabolite
Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B1779R

Sucrose (Standard)	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Microorganisms other families Source classification Plants Endogenous metabolite Saccharides	Endogenous Metabolite
Sucrose (Standard) is the analytical standard of Sucrose. This product is intended for research and analytical applications. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .

HY-136386R

N-Acetyl-D-cysteine (Standard)	Microorganisms Source classification	Reactive Oxygen Species
N-Acetyl-D-cysteine (Standard) is the analytical standard of N-Acetyl-D-cysteine. This product is intended for research and analytical applications. N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .

HY-Y1314

Dimethyl sulfone 1 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B0300R

Penicillamine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Cuproptosis Drug Metabolite
Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-N8519

Urdamycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal Antibiotic
Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .

HY-N0390R

L-Glutamine (standard) 10+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	mGluR Endogenous Metabolite Ferroptosis
L-Glutamine (Standard) is the analytical standard of L-Glutamine. This product is intended for research and analytical applications. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .

HY-101036R

Choline bitartrate (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	mAChR Endogenous Metabolite
Choline (bitartrate) (Standard) is the analytical standard of Choline (bitartrate). This product is intended for research and analytical applications. Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders . Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism .

HY-N0304R

L-DOPA (Standard) Levodopa (Standard); 3,4-Dihydroxyphenylalanine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Nervous System Disorder Endogenous metabolite	Dopamine Receptor Endogenous Metabolite
L-DOPA (Standard) is the analytical standard of L-DOPA. This product is intended for research and analytical applications. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .

HY-B0456R

Riboflavin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Bacterial
Riboflavin (Standard) is the analytical standard of Riboflavin. This product is intended for research and analytical applications. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .

HY-B0389R

D-Glucose (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite
D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-N0035R

Arctigenin (Standard)	Structural Classification Human Gut Microbiota Metabolites Source classification Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite	MMP Influenza Virus Autophagy Apoptosis
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-W013093R

Uridine triphosphate trisodium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite P2Y Receptor
Uridine triphosphate (trisodium salt) (Standard) is the analytical standard of Uridine triphosphate (trisodium salt). This product is intended for research and analytical applications. Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors .

HY-B0300

Penicillamine 2 Publications Verification D-(-)-Penicillamine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Cuproptosis Drug Metabolite
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-19528R

SAH (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Amino acids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-N4170

Chebulic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Combretaceae Source classification Phenols Polyphenols Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields	Keap1-Nrf2 Reactive Oxygen Species
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N11286R

Tridocosahexaenoylglycerol (Standard)	Structural Classification Natural Products Animals Source classification	Others
Tridocosahexaenoylglycerol (Standard) is the analytical standard of Tridocosahexaenoylglycerol. This product is intended for research and analytical applications. Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-113365

Cholestenone 4-Cholesten-3-one	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .

HY-W018772R

D-Ribose(mixture of isomers) (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
D-Ribose(mixture of isomers) (Standard) is the analytical standard of D-Ribose(mixture of isomers). This product is intended for research and analytical applications. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-14608AR

L-Glutamic acid monosodium salt (Standard)	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	iGluR Apoptosis Ferroptosis Endogenous Metabolite
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .

HY-B0399R

L-Carnitine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer	Endogenous Metabolite
L-Carnitine (Standard) is the analytical standard of L-Carnitine. This product is intended for research and analytical applications. L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-B2246R

L-Carnitine hydrochloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
L-Carnitine (hydrochloride) (Standard) is the analytical standard of L-Carnitine (hydrochloride). This product is intended for research and analytical applications. L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-114293R

Acetyl coenzyme A (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Oxidative Phosphorylation Endogenous Metabolite Autophagy
Acetyl coenzyme A (Standard) is the analytical standard of Acetyl coenzyme A. This product is intended for research and analytical applications. Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis [4].

HY-113596R

Acetyl Coenzyme A trisodium (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Oxidative Phosphorylation Endogenous Metabolite Autophagy
Acetyl Coenzyme A (trisodium) (Standard) is the analytical standard of Acetyl Coenzyme A (trisodium). This product is intended for research and analytical applications. Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis [4].

HY-10585AR

Valproic acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (sodium) (Standard) is the analytical standard of Valproic acid (sodium). This product is intended for research and analytical applications. Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

HY-N0667R

L-Asparagine (Standard)	Structural Classification Immune System Disorder Microorganisms Source classification Disease markers Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity . In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown . L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells .

HY-100560R

Abscisic acid (Standard)	Structural Classification Microorganisms other families Animals Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite	Endogenous Metabolite Proton Pump
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-N2447R

Amarogentin (Standard)	Structural Classification Gentiana scabra Bunge Iridoids Terpenoids Source classification Gentianaceae Phenols Polyphenols Plants	AMPK Apoptosis
Amarogentin (Standard) is the analytical standard of Amarogentin. This product is intended for research and analytical applications. Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

HY-N6805R

Isoeugenol acetate (Standard)	Structural Classification Simple Phenylpropanols Cananga odorata Source classification Phenylpropanoids Plants Annonaceae	Cholinesterase (ChE)
Isoeugenol acetate (Standard) is the analytical standard of Isoeugenol acetate. This product is intended for research and analytical applications. Isoeugenol acetate (Acetyl isoeugenol), an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC₅₀=77 nM; Ki=16 nM), α-glycosidase (IC₅₀=19.25 nM; Ki=21 nM), and α-amylase (IC₅₀=411.5 nM). Isoeugenol acetate is used medical and cosmetics industries for its antioxidant, anticancer, antimicrobial and anti-inflammatory properties .

HY-B2176R

ATP (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Endogenous Metabolite
ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs . ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner . ATP promotes neutrophil chemotaxis in vitro . In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo . ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .

HY-N0272R

Eleutheroside E (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Others
Eleutheroside E (Standard) is the analytical standard of Eleutheroside E. This product is intended for research and analytical applications. Eleutheroside E is an important component of Eleutheroside and has antioxidant, anti-fatigue, anti-inflammatory, antibacterial, immunomodulatory and cardioprotective effects. Eleutheroside E may inhibit the MAPK signaling pathway, thereby inhibiting H/R-induced NF-κB activation and oxidative stress, reducing metabolic reprogramming, and protecting myocardium from ischemia-reperfusion (I/R) injury. Eleutheroside E also counteracts the effects of high altitude hypobaric hypoxia (HAHI) by inhibiting inflammation and pyroptosis .

HY-14393R

Emodin (Standard) Frangula emodin (Standard)	Quinones Structural Classification Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14608R

L-Glutamic acid (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

HY-N1957R

Gamma-Mangostin (Standard)	Structural Classification Xanthones Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

HY-113325R

NADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
NADP (Standard) is the analytical standard of NADP. This product is intended for research and analytical applications. NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes . In Vitro:NADP can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival . NADP forms NAADP through IL-8-driven CD38 to mobilize Ca ²⁺ and influence cell migration . NADP de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis . NADP is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress .

Cat. No.	Product Name	Chemical Structure

HY-113439S

12-HETE-d8
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].