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Results for "

mineralocorticoid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mineralocorticoid Receptor (28) Androgen Receptor (5) Apoptosis (3) Autophagy (6) Calcium Channel (2) Drug Metabolite (2) Endogenous Metabolite (16) Glucocorticoid Receptor (7) Isotope-Labeled Compounds (5) Parasite (1) Progesterone Receptor (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (21) Endocrinology (11) Infection (1) Inflammation/Immunology (11) Metabolic Disease (10) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mineralocorticoid Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113414

Deoxycorticosterone 4 Publications Verification	Endogenous Metabolite Mineralocorticoid Receptor	Others Inflammation/Immunology
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC₅₀ of 0.16 nM . Deoxycorticosterone could acts as an immune stimulator in fish .

HY-132269

Isoflupredone	Others	Inflammation/Immunology
Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-107917

Desoxycorticosterone pivalate	Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .

HY-113313

Aldosterone Maximum Cited Publications 7 Publications Verification	Endogenous Metabolite	Cardiovascular Disease
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-N3995

5β-Dihydrocortisol	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-120274

Balcinrenone AZD9977	Mineralocorticoid Receptor	Cardiovascular Disease Metabolic Disease
Balcinrenone (AZD9977) is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator. Balcinrenone is used for heart failure, and chronic kidney disease research .

HY-123352

ZK 216348 (+)-ZK 216348	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC₅₀ of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC₅₀s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects .

HY-136969

RU 752	Mineralocorticoid Receptor	Cardiovascular Disease
RU 752 is a potent mineralocorticoid receptors (type I or MR) antagonist .

HY-132269R

Isoflupredone (Standard)	Others	Inflammation/Immunology
Isoflupredone (Standard) is the analytical standard of Isoflupredone. This product is intended for research and analytical applications. Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-107917R

Desoxycorticosterone pivalate (Standard)	Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (Standard) is the analytical standard of Desoxycorticosterone pivalate. This product is intended for research and analytical applications. Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .

HY-123352A

(-)-ZK 216348	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
(-)-ZK 216348 is the enantiomer of (+)-ZK 216348 (HY-123352). (+)-ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist with an IC₅₀ of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC₅₀s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects .

HY-14234

Glucocorticoid receptor agonist 1 Publications Verification	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .

HY-B0251

Eplerenone 5 Publications Verification Epoxymexrenone	Mineralocorticoid Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC₅₀ value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Endogenous Metabolite Apoptosis	Metabolic Disease
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-B1203

Fludrocortisone 9α-Fludrocortisone; 9α-Fluorcortisol	Mineralocorticoid Receptor	Inflammation/Immunology Cancer
Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

HY-107631

Oxprenoate potassium RU 28318	Mineralocorticoid Receptor	Endocrinology
Oxprenoate potassium is a potent mineralocorticoid (MR) antagonist. Oxprenoate potassium accentuates DEX (dexamethasone)-induced apoptosis .

HY-100471

Esaxerenone 2 Publications Verification CS-3150; XL-550	Mineralocorticoid Receptor	Cardiovascular Disease
Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist .

HY-B1203S

Fludrocortisone-d5 9α-Fludrocortisone-d₅; 9α-Fluorcortisol-d₅	Isotope-Labeled Compounds Mineralocorticoid Receptor	Inflammation/Immunology
Fludrocortisone-d₅ is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

HY-B1203S1

Fludrocortisone-d2 9α-Fludrocortisone-d₂; 9α-Fluorcortisol-d₂	Isotope-Labeled Compounds Mineralocorticoid Receptor	Inflammation/Immunology
Fludrocortisone-d₂ is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

HY-113313S1

Aldosterone-d7	Endogenous Metabolite	Cardiovascular Disease
Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-113313R

Aldosterone (Standard)	Endogenous Metabolite	Cardiovascular Disease
Aldosterone (Standard) is the analytical standard of Aldosterone. This product is intended for research and analytical applications. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-B1618S1

Corticosterone-d4	Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1618S

Corticosterone-d8	Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1203A

Fludrocortisone acetate 1 Publications Verification 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate	Mineralocorticoid Receptor Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
Fludrocortisone acetate (9α-Fludrocortisone acetate) is a synthetic mineralocorticoid with potential use in Addison's disease to reduce urinary sodium loss and to increase blood pressure.

HY-W751098

Aldosterone-13C3	Isotope-Labeled Compounds	Others
Aldosterone- ¹³C₃ is a ¹³C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.

HY-109002

Apararenone MT-3995	Mineralocorticoid Receptor	Cardiovascular Disease Metabolic Disease
Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

HY-B1582A

Canrenoate potassium Aldadiene potassium; SC-14266	Mineralocorticoid Receptor	Cardiovascular Disease
Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension .

HY-N2337

11beta-Hydroxyprogesterone 4 Publications Verification 11β-Hydroxyprogesterone	Endogenous Metabolite	Cardiovascular Disease
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-113414S

Deoxycorticosterone-d8	Endogenous Metabolite	Others
Deoxycorticosterone-d₈ is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

HY-113414R

Deoxycorticosterone (Standard)	Endogenous Metabolite	Others
Deoxycorticosterone (Standard) is the analytical standard of Deoxycorticosterone. This product is intended for research and analytical applications. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

HY-B1472

Deoxycorticosterone acetate 2 Publications Verification 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate	Mineralocorticoid Receptor Endogenous Metabolite	Endocrinology
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .

HY-113313S2

Aldosterone-d4	Endogenous Metabolite	Cardiovascular Disease
Aldosterone-d₄ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t

HY-107461

LY2623091	Glucocorticoid Receptor	Cardiovascular Disease
LY2623091 is a mineralocorticoid receptor antagonist for the treatment of refractory hypertension. LY2623091 exhibits CYP3A4-dependent clearance and synergistic effects with CYP3A4 inhibitors .

HY-113151

18-Oxocortisol	Mineralocorticoid Receptor Endogenous Metabolite	Cardiovascular Disease
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring *mineralocorticoid* agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling .

HY-12738

PF-3882845	Mineralocorticoid Receptor Progesterone Receptor	Cardiovascular Disease Metabolic Disease
PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC₅₀=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC₅₀ of 310 nM .

HY-B0561S1

Spironolactone-d3 SC9420-d₃	Mineralocorticoid Receptor Androgen Receptor Autophagy	Metabolic Disease Cancer
Spironolactone-d₃ is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-B0561S

Spironolactone-d7 SC9420-d₇	Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Metabolic Disease Cancer
Spironolactone-d₇ is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-B1472R

Deoxycorticosterone acetate (Standard) 2 Publications Verification 11-Deoxycorticosterone acetate(Standard); DOC acetate(Standard); Cortexone acetate (Standard)	Mineralocorticoid Receptor Endogenous Metabolite	Endocrinology
Deoxycorticosterone acetate (Standard) is the analytical standard of Deoxycorticosterone acetate. This product is intended for research and analytical applications. Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .

HY-B0561S2

Spironolactone-d3-1 SC9420-d₃-1	Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy	Metabolic Disease Cancer
Spironolactone-d₃-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-114154

AL-438	Glucocorticoid Receptor	Inflammation/Immunology
AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with K_is of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity .

HY-B0561R

Spironolactone (Standard) 3 Publications Verification SC9420 (Standard)	Mineralocorticoid Receptor Androgen Receptor Autophagy	Metabolic Disease Cancer
Spironolactone (Standard) is the analytical standard of Spironolactone. This product is intended for research and analytical applications. Spironolactone (SC9420) is an orally active *aldosterone mineralocorticoid* receptor antagonist with an IC₅₀ of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC₅₀ of 77 nM. Spironolactone promotes autophagy** in podocytes .

HY-111372A

(Rac)-Finerenone (Rac)-BAY 94-8862	Mineralocorticoid Receptor	Cardiovascular Disease
(Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold) .

HY-W011243

11alpha-Hydroxyprogesterone	Others	Cardiovascular Disease
11alpha-Hydroxyprogesterone is the analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-130431

Vinclozolin M2	Parasite	Infection
Vinclozolin M2 is an active metabolite of vinclozolin. It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC₅₀=1,400 nM) and androgen receptor (IC₅₀=0.17 nM) in reporter assays using MCF-7 cells.

HY-N3995S

5β-Dihydrocortisol-d6	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

HY-B0251R

Eplerenone (Standard) 5 Publications Verification Epoxymexrenone (Standard)	Mineralocorticoid Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Eplerenone (Standard) is the analytical standard of Eplerenone. This product is intended for research and analytical applications. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC₅₀ value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .

HY-111372

Finerenone 2 Publications Verification BAY 94-8862	Mineralocorticoid Receptor	Cardiovascular Disease
Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-111372S

Finerenone-d3 BAY 94-8862-d₃	Mineralocorticoid Receptor	Others
Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-111372R

Finerenone (Standard)	Mineralocorticoid Receptor	Cardiovascular Disease
Finerenone (Standard) is the analytical standard of Finerenone. This product is intended for research and analytical applications. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-B0561

Spironolactone 3 Publications Verification SC9420	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the *aldosterone mineralocorticoid* receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (AngⅡ)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type Ⅱ diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺** channels to exert antihypertensive effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113414

Deoxycorticosterone 4 Publications Verification	Structural Classification Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Mineralocorticoid Receptor
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC₅₀ of 0.16 nM . Deoxycorticosterone could acts as an immune stimulator in fish .

HY-113313

Aldosterone Maximum Cited Publications 7 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-N3995

5β-Dihydrocortisol	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Apoptosis Drug Metabolite
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-B0251

Eplerenone 5 Publications Verification Epoxymexrenone	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Mineralocorticoid Receptor Endogenous Metabolite
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC₅₀ value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-N2337

11beta-Hydroxyprogesterone 4 Publications Verification 11β-Hydroxyprogesterone	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-B1472

Deoxycorticosterone acetate 2 Publications Verification 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Mineralocorticoid Receptor Endogenous Metabolite
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .

HY-113151

18-Oxocortisol	Cardiovascular Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Mineralocorticoid Receptor Endogenous Metabolite
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring *mineralocorticoid* agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling .

HY-113313R

Aldosterone (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Aldosterone (Standard) is the analytical standard of Aldosterone. This product is intended for research and analytical applications. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .

HY-113414R

Deoxycorticosterone (Standard)	Structural Classification Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Deoxycorticosterone (Standard) is the analytical standard of Deoxycorticosterone. This product is intended for research and analytical applications. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

HY-B1472R

Deoxycorticosterone acetate (Standard) 2 Publications Verification 11-Deoxycorticosterone acetate(Standard); DOC acetate(Standard); Cortexone acetate (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Mineralocorticoid Receptor Endogenous Metabolite
Deoxycorticosterone acetate (Standard) is the analytical standard of Deoxycorticosterone acetate. This product is intended for research and analytical applications. Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .

Cat. No.	Product Name	Chemical Structure

HY-113313S1

Aldosterone-d7

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-B1618S1

Corticosterone-d4
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1618S

Corticosterone-d8
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-113414S

Deoxycorticosterone-d8
Deoxycorticosterone-d₈ is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

HY-113313S2

Aldosterone-d4
Aldosterone-d₄ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t

HY-B0561S1

Spironolactone-d3
Spironolactone-d₃ is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-B0561S

Spironolactone-d7
Spironolactone-d₇ is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-B1203S

Fludrocortisone-d5
Fludrocortisone-d₅ is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

HY-B1203S1

Fludrocortisone-d2
Fludrocortisone-d₂ is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

HY-W751098

Aldosterone-13C3
Aldosterone- ¹³C₃ is a ¹³C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.

HY-B0561S2

Spironolactone-d3-1
Spironolactone-d₃-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

HY-N3995S

5β-Dihydrocortisol-d6
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

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