Search Result
Results for "
phosphate
" in MedChemExpress (MCE) Product Catalog:
9
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-134393B
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N6-Methyl-ATP (trisodium) solution (100mM)
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GSK-3
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Others
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6-Me-ATP (N6-Methyl-ATP) trisodium solution (100mM) is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
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-
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- HY-P2992
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PPase
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Endogenous Metabolite
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Others
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Inorganic pyrophosphatase, Saccharomyces cerevisiae (PPase) converts pyrophosphate (PPi) to phosphate. Inorganic pyrophosphatase is an essential component of in vitro transcription reactions for RNA preparation, is often used in biochemical studies. Inorganic pyrophosphatase is critical for driving cellular processes such as nucleic acid and protein synthesis .
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-
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- HY-B0504S
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-
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- HY-134393
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N6-Methyl-ATP
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GSK-3
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Others
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6-Me-ATP (N6-Methyl-ATP) is a N 6-modified ATP derivative. 6-Me-ATP shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
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-
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- HY-W110917
-
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Biochemical Assay Reagents
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Others
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Dimethylsulfonazo III is a potent sulfate indicator. Dimethylsulfonazo III can be used as indicator to test those samples contaminated with potassium or phosphate ions .
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-
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- HY-P10211
-
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Antibiotic
Bacterial
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Infection
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Virgilagicin is a Gram-positive active antibiotic that has a dual polyprenyl phosphate binding mechanism that impedes resistance development .
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-
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- HY-P10209
-
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Antibiotic
Bacterial
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Infection
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Cilagicin, a dodeca-lipodepsipeptide, is a Gram-positive active antibiotic. Cilagicin has a dual polyprenyl phosphate binding mechanism that impedes resistance development .
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-
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- HY-W094708D
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Disodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP
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Biochemical Assay Reagents
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Others
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Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .
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-
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- HY-135655A
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SPR720; pVXc-486
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Bacterial
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Infection
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Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo .
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-
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- HY-16505
-
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Endogenous Metabolite
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Neurological Disease
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Triclofos sodium is a drug used to suppress insomnia and for sedation and has sedative activity. Triclofos sodium is used in children for sedation during painless medical procedures, particularly in children with neurocognitive disorders. Triclofos sodium has similar physiological and pharmacological properties to chloral and therefore can be used as a substitute when necessary. The safety and efficacy of Triclofos sodium have been demonstrated in pediatric populations with high rates of neurocognitive disorders .
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-
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- HY-P2952
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AMPK; Myokinase; Adk
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Endogenous Metabolite
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Others
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Adenylate (Adk), i.e., myokinase, is a phosphotransferase enzyme, is often used in biochemical studies. Adenylate catalyzes the interconversion of adenosine phosphates. Adenylate monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .
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-
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- HY-Y0308H
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Disodium hydrogen phosphate, for molecular biology
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Biochemical Assay Reagents
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Others
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Sodium phosphate dibasic, for molecular biology is an inorganic salt that can be used for life science related research .
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-
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- HY-125863A
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G6PD (Leuconostoc sp., recombinant)
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Endogenous Metabolite
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Metabolic Disease
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Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase .
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-
-
- HY-P10119
-
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PDGFR
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Others
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PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response .
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-
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- HY-P0320B
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Phosphatase
Biochemical Assay Reagents
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Others
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EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
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-
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- HY-P3061
-
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Bradykinin Receptor
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Cardiovascular Disease
Endocrinology
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[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .
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- HY-122415
-
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Antibiotic
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Infection
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Tunicamine is a high carbohydrate antibiotic that is part of the structure of Tunicamycin. Tunicamycin is a nucleoside antibiotic and a reversible polyprenol-phosphate inhibitor .
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-
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- HY-125150
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-
-
- HY-P10270
-
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PDGFR
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Others
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PDGFR Y1021 peptide (phosphorylation) is the phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (phosphorylation) supports association of PLCγ to PDGFR through PLCγSH2 domains, and thus promotes the production of inositol phosphates and mitogenic response .
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-
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- HY-107469
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Pyridoxaldehyde
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS) .
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-
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- HY-P0320A
-
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Phosphatase
Biochemical Assay Reagents
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Others
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EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
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-
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- HY-107469R
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-
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- HY-B2243BR
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Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard) is the analytical standard of Anhydrous sodium dihydrogen phosphate, for molecular biology. This product is intended for research and analytical applications. Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
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-
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- HY-Y0302S
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Biochemical Assay Reagents
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Others
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Diammonium phosphate- 15N2 is 15N2 labeled Diammonium phosphate (HY-Y0302). Diammonium phosphate is a neutral and efficient catalyst in 1,8-Dioxo-octahydroxanthene derivatives synthesis, which can be used as an excipient, such as diuretic, buffer, effervescent .
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- HY-135655
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SPR720 disodium; pVXc-486 disodium
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Bacterial
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Infection
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Fobrepodacin (SPR720) disodium is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potent bactericidal activities in vivo .
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-
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- HY-B2243D
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Sodium phosphate monobasic, for cell culture; Monosodium dihydrogen orthophosphate, for cell culture; Monosodium phosphate, for cell culture
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Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .
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-
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- HY-P2931
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TPI
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Endogenous Metabolite
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Others
Cancer
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Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .
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-
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- HY-P4987
-
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Protease Activated Receptor (PAR)
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Cardiovascular Disease
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TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .
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-
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- HY-P2818B
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Apase, Chicken Intestine
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Endogenous Metabolite
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Metabolic Disease
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Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values .
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-
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- HY-15991A
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AZD1722 hydrochloride; RDX5791 hydrochloride
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Na+/H+ Exchanger (NHE)
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Metabolic Disease
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Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .
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- HY-P10210
-
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Antibiotic
Bacterial
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Infection
|
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .
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- HY-168061
-
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Bacterial
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Infection
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HldA/E-IN-1 (compound 8) is a dual inhibitor of HldA/E, with IC50 values of 17.2 μM and 67.8 μM for HldA/E, respectively. HldA/E-IN-1 can be used in the study of anti-bacterial infection .
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-
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- HY-136128
-
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Potassium Channel
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Cancer
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H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity .
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-
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- HY-15991
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AZD1722; RDX5791
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Na+/H+ Exchanger (NHE)
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Metabolic Disease
|
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .
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- HY-P2818D
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Apase, Human liver
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Endogenous Metabolite
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Metabolic Disease
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Alkaline phosphatase (Apase), Human liver is a glycoprotein bound to plasma membranes that hydrolyzes several monophosphate esters optimally at an alkaline pH with the release of inorganic phosphates .
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-
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- HY-B2243B
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Sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
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Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
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-
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- HY-D0843
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NEM
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Cathepsin
Deubiquitinase
Apoptosis
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Others
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N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
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- HY-147063R
-
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Endogenous Metabolite
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Others
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Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .
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-
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- HY-125863
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G6PD
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .
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- HY-D0162
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MCCK1
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Fungal
IKK
NF-κB
Apoptosis
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Infection
Cancer
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Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes, insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .
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- HY-D0843R
-
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Cathepsin
Deubiquitinase
Apoptosis
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Others
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Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition .
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-
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- HY-P2818
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Apase
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .
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-
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- HY-113511C
-
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Biochemical Assay Reagents
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Others
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Glycogen, from bovine liver, ≥85% is a biochemical reagent that can be used as a biomaterial or organic compound for life science related research .
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-
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- HY-147063
-
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Endogenous Metabolite
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Others
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N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, is a key intermediate in the biosynthesis of N-linked glycoproteins. N-acetyl-α-d-glucosamine 1-phosphate disodium is a metabolic precursor of the bacterial cell-wall components teichoic acid and mureine .
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-
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- HY-D0162R
-
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Fungal
IKK
NF-κB
Apoptosis
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Infection
Cancer
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Malachite green hemioxalate (Standard) is the analytical standard of Malachite green hemioxalate (HY-D0162). This product is intended for research and analytical applications. Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antimicrobial activity, which is attributed to inhibition of intracellular enzymes, intercalation into DNA, and/or interaction with cellular membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
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- HY-154924
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-
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- HY-114667
-
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EGFR
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Others
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Lavendustin C6 is a specific inhibitor of tyrosine kinase. Lavendustin C6 inhibits epidermal growth factor (EGF) receptor tyrosine kinase with an EC50 value of 0.05 μg/mL. Lavendustin C6 inhibits platelet-derived growth factor (PDGF)-induced inositol phosphate formation .
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-
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- HY-D0835A
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Hydroxyapatite (<50 nm)
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Biochemical Assay Reagents
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Cardiovascular Disease
Inflammation/Immunology
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Hydroxylapatite (Hydroxyapatite) (<50 nm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (<50 nm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (<50 nm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (<50 nm) can be used in research on osteoarthritis, gout, and atherosclerosis .
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-
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- HY-135864
-
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Ras
|
Cancer
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KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .
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-
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- HY-145781
-
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Drug Intermediate
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Metabolic Disease
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β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis .
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- HY-135866
-
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Ras
|
Cancer
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KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .
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-
- HY-112939
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MCI-196; Colestimide
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Biochemical Assay Reagents
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Metabolic Disease
|
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .
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- HY-N1673
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Gentisaldehyde
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Bacterial
|
Infection
|
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus strains with a MIC50 of 500 mg/L .
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- HY-160113
-
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Biochemical Assay Reagents
|
Others
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Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.
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- HY-N1673R
-
-
- HY-135865
-
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Ras
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Cancer
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KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .
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- HY-N1428CR
-
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Antibiotic
Reactive Oxygen Species
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Metabolic Disease
|
Cephradine (monohydrate) (Standard) is the analytical standard of Cephradine (monohydrate). This product is intended for research and analytical applications. Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .
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- HY-147062
-
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Biochemical Assay Reagents
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Metabolic Disease
|
N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate can be hydrolyze by NagA .
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-
- HY-E70067
-
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Biochemical Assay Reagents
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Others
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GlcNAc 1-P uridyltransferase (PmGlmU) catalyzes high efficient synthesis of UDP-GlcNAc from GlcNAc-1-P and UTP. GlcNAc 1-P uridyltransferase (PmGlmU) is used to break down the pyrophosphate formed in the PmGlmU reaction to inorganic phosphate to shift the equilibrium of the coupled enzymatic reactions towards the formation of UDP-GlcNA .
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- HY-W601362
-
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Endogenous Metabolite
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Metabolic Disease
|
N-Acetyl-D-galactosamine-6-phosphate disodium is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate disodium can be hydrolyze by NagA .
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- HY-E70382
-
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Phosphatase
Biochemical Assay Reagents
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Others
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Shrimp Alkaline Phosphatase (SAP), a nucleotide phosphatase, can catalyze the removal of 5′ phosphates from nucleic acid templates. Shrimp Alkaline Phosphatase is readily inactivated in the absence of chelators and is widely used phosphatases in molecular cloning .
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-
- HY-103138
-
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5-HT Receptor
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Neurological Disease
Metabolic Disease
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(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects .
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- HY-N3394
-
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Others
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Infection
|
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .
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- HY-103138A
-
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5-HT Receptor
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Neurological Disease
Metabolic Disease
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(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects .
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- HY-19619
-
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Phospholipase
Apoptosis
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Cancer
|
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
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- HY-N1428C
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Iron(III) citrate; Zerenex
|
Reactive Oxygen Species
Antibiotic
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Metabolic Disease
|
Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .
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-
- HY-100912
-
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Phosphodiesterase (PDE)
Myosin
Apoptosis
Calmodulin
|
Cancer
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W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca 2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively . W-7 hydrochloride induces apoptosis and has antitumor activity .
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-
- HY-103305
-
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Fluorescent Dye
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Cancer
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cis-Ned19 is a chemical probe. cis-Ned19 blocks NAADP signaling and fluorescently labeled NAADP receptors in cell .
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- HY-107510
-
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mGluR
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Neurological Disease
|
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models .
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- HY-137325
-
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Guanylate Cyclase
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Others
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2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production .
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- HY-131892
-
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Endogenous Metabolite
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Metabolic Disease
Cancer
|
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo .
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-
- HY-131041
-
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Calcium Channel
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Cardiovascular Disease
|
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca 2+ oscillations in cardiomyocytes .
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-
- HY-108662
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2,2'-Pyridylisatogen tosylate
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P2Y Receptor
|
Inflammation/Immunology
Cancer
|
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .
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-
- HY-131615
-
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Sodium Channel
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Others
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TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells .
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-
- HY-135124
-
|
ADC Cytotoxin
|
Cancer
|
DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer .
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- HY-135123
-
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ADC Cytotoxin
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Cancer
|
DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer .
|
-
- HY-144318
-
|
Epigenetic Reader Domain
|
Cancer
|
CREB-IN-1 TFA is a potent, orally active CREB inhibitor (IC50=0.18 µM). CREB-IN-1 TFA inhibits breast cancer cell growth .
|
-
- HY-13995B
-
|
Others
|
Metabolic Disease
|
Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995) .
|
-
- HY-131614
-
|
Calcium Channel
|
Others
|
TPC2-A1-N is a powerful and Ca 2+-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca 2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells .
|
-
- HY-135125
-
|
ADC Cytotoxin
|
Cancer
|
DC4, an ADC cytotoxin, can be used in the synthesis of antibody-drug conjugate (ADC). DC4 can be used for the targeted treatment of cancer .
|
-
- HY-107620
-
|
MEK
|
Neurological Disease
|
PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects .
|
-
- HY-154857
-
|
Scavenger Receptor Class B type I (SR-BI)
|
Cancer
|
1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0162
-
MCCK1
|
Fluorescent Dyes/Probes
|
Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes, insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .
|
-
- HY-D0162R
-
|
Fluorescent Dyes/Probes
|
Malachite green hemioxalate (Standard) is the analytical standard of Malachite green hemioxalate (HY-D0162). This product is intended for research and analytical applications. Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antimicrobial activity, which is attributed to inhibition of intracellular enzymes, intercalation into DNA, and/or interaction with cellular membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
|
Cat. No. |
Product Name |
Type |
-
- HY-134393B
-
N6-Methyl-ATP (trisodium) solution (100mM)
|
Gene Sequencing and Synthesis
|
6-Me-ATP (N6-Methyl-ATP) trisodium solution (100mM) is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
|
-
- HY-B2243D
-
Sodium phosphate monobasic, for cell culture; Monosodium dihydrogen orthophosphate, for cell culture; Monosodium phosphate, for cell culture
|
Buffer Reagents
|
Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .
|
-
- HY-B2243B
-
Sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
|
Buffer Reagents
|
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
|
-
- HY-113511C
-
|
Carbohydrates
|
Glycogen, from bovine liver, ≥85% is a biochemical reagent that can be used as a biomaterial or organic compound for life science related research .
|
-
- HY-160113
-
|
Buffer Reagents
|
Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.
|
-
- HY-W094708D
-
Disodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP
|
Buffer Reagents
|
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .
|
-
- HY-Y0308H
-
Disodium hydrogen phosphate, for molecular biology
|
Buffer Reagents
|
Sodium phosphate dibasic, for molecular biology is an inorganic salt that can be used for life science related research .
|
-
- HY-B2243BR
-
|
Buffer Reagents
|
Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard) is the analytical standard of Anhydrous sodium dihydrogen phosphate, for molecular biology. This product is intended for research and analytical applications. Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
|
-
- HY-154924
-
S-NADP
|
Biochemical Assay Reagents
|
Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca 2+ release .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P3061
-
|
Bradykinin Receptor
|
Cardiovascular Disease
Endocrinology
|
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .
|
-
- HY-P4987
-
|
Protease Activated Receptor (PAR)
|
Cardiovascular Disease
|
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .
|
-
- HY-P10211
-
|
Antibiotic
Bacterial
|
Infection
|
Virgilagicin is a Gram-positive active antibiotic that has a dual polyprenyl phosphate binding mechanism that impedes resistance development .
|
-
- HY-P10209
-
|
Antibiotic
Bacterial
|
Infection
|
Cilagicin, a dodeca-lipodepsipeptide, is a Gram-positive active antibiotic. Cilagicin has a dual polyprenyl phosphate binding mechanism that impedes resistance development .
|
-
- HY-P10119
-
|
PDGFR
|
Others
|
PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response .
|
-
- HY-P0320B
-
|
Phosphatase
Biochemical Assay Reagents
|
Others
|
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
|
-
- HY-P10270
-
|
PDGFR
|
Others
|
PDGFR Y1021 peptide (phosphorylation) is the phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (phosphorylation) supports association of PLCγ to PDGFR through PLCγSH2 domains, and thus promotes the production of inositol phosphates and mitogenic response .
|
-
- HY-P0320A
-
|
Phosphatase
Biochemical Assay Reagents
|
Others
|
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
|
-
- HY-P10210
-
|
Antibiotic
Bacterial
|
Infection
|
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-B0504S
-
-
-
- HY-107469
-
-
-
- HY-D0843
-
NEM
|
Microorganisms
Source classification
|
Cathepsin
Deubiquitinase
Apoptosis
|
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
|
-
-
- HY-125863
-
G6PD
|
Structural Classification
Natural Products
Classification of Application Fields
Source classification
Metabolic Disease
Endogenous metabolite
Disease Research Fields
Cancer
|
Endogenous Metabolite
|
Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .
|
-
-
- HY-P2818
-
-
-
- HY-147063
-
-
-
- HY-125150
-
-
-
- HY-107469R
-
-
-
- HY-147063R
-
|
Structural Classification
Natural Products
Source classification
Endogenous metabolite
|
Endogenous Metabolite
|
Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .
|
-
-
- HY-D0843R
-
-
-
- HY-145781
-
-
-
- HY-N1673
-
-
-
- HY-N1673R
-
-
-
- HY-N3394
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0504S
-
4 Publications Verification
|
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .
|
-
-
- HY-Y0302S
-
|
Diammonium phosphate- 15N2 is 15N2 labeled Diammonium phosphate (HY-Y0302). Diammonium phosphate is a neutral and efficient catalyst in 1,8-Dioxo-octahydroxanthene derivatives synthesis, which can be used as an excipient, such as diuretic, buffer, effervescent .
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-B2243B
-
Sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
|
|
Others
|
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
|
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