Search Result
Results for "
piperidines
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-W013727
-
|
Potassium Channel
|
Inflammation/Immunology
|
UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil .
|
-
-
- HY-100305
-
|
Others
|
Endocrinology
|
Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.
|
-
-
- HY-135670A
-
|
Glucosidase
|
Metabolic Disease
|
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity .
|
-
-
- HY-N3526
-
|
Others
|
Others
|
Calyxamine B is a piperidine alkaloid that can be isolated from Calyx podatypa .
|
-
-
- HY-W012935
-
Piperidine-4-carboxaldehyde
|
PROTAC Linkers
|
Cancer
|
Piperidine-4-carbaldehyde (Piperidine-4-carboxaldehyde) is a PROTAC Linker. Piperidine-4-carbaldehyde can be used to optimize combined with the target protein affinity, thus improve the PROTAC the molecular degradation efficiency. Piperidine-4-carbaldehyde can be used in the CDK2 PROTACs (HY-161708) .
|
-
-
- HY-W012748S
-
-
-
- HY-W584986
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-(2)piperidine (compound 9) is a potent E3 ligase ligand. Thalidomide-(2)piperidine can be used for synthesis of PROTACs .
|
-
-
- HY-150666S
-
-
-
- HY-125828
-
|
Bacterial
|
Infection
|
1-(3,4-Dimethoxycinnamoyl)piperidine, a synthesized piperidine analog, possesses antimicrobial and antioxidant activity .
|
-
-
- HY-33540S
-
-
-
- HY-161202
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-O-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-piperidine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-139116
-
-
-
- HY-169050
-
-
-
- HY-138783A
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
|
-
-
- HY-121229A
-
2-Propylpiperidine
|
Others
|
Others
|
(±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock .
|
-
-
- HY-168203
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-piperidine-O-Ph-NH2 is the conjugate of E3 ligase and linker. Thalidomide-piperidine-O-Ph-NH2 can be used for synthesis of PROTAC degrader MJP6412 (HY-168201) .
|
-
-
- HY-168217
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-piperazine-piperidine-2-F-Ph-CHO is a E3 ligase ligand-linker conjugate, which is consisted of a Thalidomide (HY-14658) and a linker Boc-Piperazine-piperidine-2-F-Ph-CHO (HY-168218). Thalidomide-piperazine-piperidine-2-F-Ph-CHO is utilized for synthesis of PROTAC molecule YDR1 (HY-168215) .
|
-
-
- HY-168039
-
|
PROTAC Linkers
|
Cancer
|
Boc-NH-Piperidine-C5-OH is a PROTAC linker. Boc-NH-Piperidine-C5-OH can be used in the synthesis of PROTAC PIN1 degrader-1 (HY-168037) .
|
-
-
- HY-168231
-
|
PROTAC Linkers
|
Cancer
|
trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH is a PROTAC linker. trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .
|
-
-
- HY-130983
-
|
Btk
Ligands for Target Protein for PROTAC
|
Cancer
|
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively . N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM .
|
-
-
- HY-121964
-
|
iGluR
|
Neurological Disease
|
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .
|
-
-
- HY-163237
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-O-azetidineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-azetidineethanol can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-163232
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Phthalimidinoglutarimide-piperidine-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-piperidine-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-E70249
-
S-[(3S)-3-Hydroxydecanoate]-CoA
|
Endogenous Metabolite
|
Others
|
3-Hydroxydecanoyl-CoA (S-[(3S)-3-Hydroxydecanoate]-CoA) is a coenzyme, which is the main substrate for the synthesis enzyme PhaC1 of 1-benzyloxycarbonyl piperidine-4-yl acetic acid (PHA) in P. aeruginosa .
|
-
-
- HY-12760S
-
-
-
- HY-168227
-
|
PROTAC Linkers
|
Cancer
|
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc is a PROTAC linker. trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc can be used in the synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225) .
|
-
-
- HY-163236
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-O-azetidine-acetic acid is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-azetidine-acetic acid can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-163234
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Phthalimidinoglutarimide-piperidine-NH2 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-piperidine-NH2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-168040
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-O-C5-piperidine-NH-Boc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-O-C5-piperidine-NH-Boc can be used to synthesize PROTAC PIN1 degrader-1 (HY-168037) .
|
-
-
- HY-168272
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
(3S)Lenalidomide-piperazine-C-piperidine is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). (3S)Lenalidomide-piperazine-C-piperidine can be used to synthesize PROTAC PROTAC ER Degrader-11 (HY-168270) .
|
-
-
- HY-163922
-
-
-
- HY-161195
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Deoxy-thalidomide-piperidine-C-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-161198
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-azetidine-pyrrolidine-C-piperidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-pyrrolidine-C-piperidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-W904851
-
|
PROTAC Linkers
|
Cancer
|
Boc-Piperidine-piperazine-Cbz is a PROTAC linker that can be used in the synthesis of ZLC491 (HY-168162) .
|
-
-
- HY-168239
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates). Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph can be used for the synthesis of PROTAC SMARCA2 degrader-28 (HY-168236) .
|
-
-
- HY-43459
-
-
-
- HY-161184
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Deoxy-thalidomide-piperidine-C-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-161199
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-azetidine-pyrrolidine-C-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-pyrrolidine-C-piperidine-C2-OH can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-159684
-
|
PROTAC Linkers
|
Cancer
|
3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker. 3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin can be used in the synthesis PROTAC SMARCA2/4-degrader-30 (HY-162748) .
|
-
-
- HY-18373
-
|
Others
|
Cancer
|
UNC1079 is the piperidine analog of UNC1021, as a structurally similar but significantly less potent inhibitor for use as a negative control in cellular studies.
|
-
-
- HY-161186
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-C-azetidine-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-C-azetidine-C2-O-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-114791
-
|
nAChR
|
Neurological Disease
|
Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC50 of 2.8 and 8.2 μM .
|
-
-
- HY-161185
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-piperidine-O-azetidine-boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
|
-
-
- HY-161187
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
-
- HY-159682
-
|
PROTAC Linkers
|
Cancer
|
3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker. 3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin can be used in the synthesis PROTAC SMARCA2/4-degrader-29 (HY-162743) .
|
-
-
- HY-W694291
-
|
Others
|
Others
|
Clibucaine is a piperidine derivative possessing local agent that can suppress or relieve pain. Clibucaine can be used as a local agent that can suppress or relieve pain .
|
-
-
- HY-105545
-
(+)-Benzetimide; (S)-(+)-Dexetimide; Dexbenzetimide
|
mAChR
|
Neurological Disease
|
Dexetimide ((+)-Benzetimide; (S)-(+)-Dexetimide; Dexbenzetimide) is a piperidine anticholinergic and a high-affinity muscarinic receptor antagonist. Dexetimide can be used in studies of parkinson's disease .
|
-
-
- HY-138783
-
-
-
- HY-40014
-
1-Boc-Piperidine-3-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
1-Boc-piperidine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-40007
-
|
Biochemical Assay Reagents
|
Others
|
1-Boc-4-(aminomethyl)piperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-168218
-
|
PROTAC Linkers
|
Cancer
|
Boc-Piperazine-piperidine-2-F-Ph-CHO is a PROTAC linker that can be used in the synthesis of YDR1 (HY-168215) .
|
-
- HY-161204
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-O-C4H4-N(Me)-piperidine-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-O-C4H4-N(Me)-piperidine-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-159490
-
-
- HY-161192
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-O-C4H4-N(Me)-piperidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-O-C4H4-N(Me)-piperidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-161196
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-163229
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
(1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-162791
-
|
PROTAC Linkers
|
Cancer
|
(1s,4s)-C1-Piperidine-C1-cyclohexane-C1 is a PROTAC linker. (1s,4s)-C1-Piperidine-C1-cyclohexane-C1 can be used to synthesize PROTAC SMARCA2/4-degrader-33 (HY-162741) .
|
-
- HY-168197
-
|
PROTACs
|
Cancer
|
Thalidomide-F-piperidine-piperazine-Cbz Conjugate 110 is a conjugate of E3 ligase and linker for the synthesis of CDK12/13 PROTAC degrader (HY-168162) .
|
-
- HY-147101
-
|
PARP
|
Cancer
|
SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM .
|
-
- HY-161188
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-O-C4H4-N(Me)-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-O-C4H4-N(Me)-piperidine-C2-OH can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-161190
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-B0366A
-
|
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
Cancer
|
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders .
|
-
- HY-B1622
-
-
- HY-B1622R
-
|
5-HT Receptor
Apoptosis
|
Cardiovascular Disease
Neurological Disease
|
Cyproheptadine (Standard) is the analytical standard of Cyproheptadine. This product is intended for research and analytical applications. Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders .
|
-
- HY-B0366AR
-
|
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
Cancer
|
Cyproheptadine (hydrochloride) (Standard) is the analytical standard of Cyproheptadine (hydrochloride). This product is intended for research and analytical applications. Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders .
|
-
- HY-40226
-
|
Biochemical Assay Reagents
|
Others
|
4-Amino-1-Boc-piperidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-163219
-
-
- HY-158862
-
|
Liposome
|
Others
|
BP Lipid 376 features a unique piperidine ionizable head group with a carbamate linkage to the lipid scaffold comprised of a linoleate ester and aliphatic acetal ester. This lipid may be used in the development of lipid nanoparticles for drug delivery.
|
-
- HY-161189
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C-boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-163224
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-163228
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-169141
-
-
- HY-168297
-
|
PROTAC Linkers
|
Cancer
|
Piperidine-C2-Pip-C-COOH is a linker for PROTAC BTK Degrader-5 (HY-155072), significantly improving metabolic stability, and can be used in cancer research .
|
-
- HY-120081A
-
|
Others
|
Neurological Disease
|
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride hydrate potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used for the research of parkinsonian .
|
-
- HY-120081B
-
|
Others
|
Neurological Disease
|
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian .
|
-
- HY-120081
-
|
Others
|
Neurological Disease
|
Metixene (Piperidine) is an anticholinergic and antiparkinsonian agent. Metixene potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene can be used for the research of parkinsonian .
|
-
- HY-163222
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
|
-
- HY-157566
-
|
Ligands for E3 Ligase
|
Cancer
|
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated .
|
-
- HY-15242
-
CP 424391
|
GHSR
|
Endocrinology
|
Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM) .
|
-
- HY-168304
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research .
|
-
- HY-W697671S
-
|
Isotope-Labeled Compounds
|
Others
|
Paroxetine-d6 (hydrochloride) is deuterium labeled trans-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride .
|
-
- HY-131386A
-
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
|
-
- HY-161197
-
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-163220
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-158866
-
|
Liposome
|
Others
|
BP Lipid 401 is derived from patent WO2020219876A1 (Example 102). BP Lipid 401 features a unique piperidine head group three carbon atoms in length. This compound can be useful for the building or modification of lipid nanoparticles.
|
-
- HY-131386
-
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
|
-
- HY-134592
-
-
- HY-143452
-
|
Tyrosinase
Bacterial
|
Inflammation/Immunology
|
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent .
|
-
- HY-168298
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Lenalidomide-6-F-piperidine-C2-Pip-C-COOH is a linker and E3 ligase ligand for PROTAC BTK Degrader-5 (HY-155072) and can be used in malignant lymphoma research .
|
-
- HY-168244
-
|
PROTAC Linkers
|
Cancer
|
TsO-C2-Piperidine-O-azetidine-CO-Ph-C2-OH is a PROTAC linker, and can be used for PROTAC synthesis, such as PROTAC BRM/BRG1 degrader-1 (HY-168242) .
|
-
- HY-B1482
-
TPS-23 benzenesulfonate
|
Potassium Channel
|
Neurological Disease
|
Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
|
-
- HY-B1482A
-
TPS-23
|
Potassium Channel
|
Neurological Disease
|
Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
|
-
- HY-120081AR
-
|
Others
|
Neurological Disease
|
Metixene (hydrochloride hydrate) (Standard) is the analytical standard of Metixene (hydrochloride hydrate). This product is intended for research and analytical applications. Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride hydrate potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used for the research of parkinsonian .
|
-
- HY-Z1430S
-
(3R,4S)-BRL29060-d4 hydrochloride; (3R,4S)-BRL29060A-d4
|
Drug Metabolite
Isotope-Labeled Compounds
|
Others
|
Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
|
-
- HY-135653A
-
(Rac)-BPN-19186
|
Epoxide Hydrolase
|
Neurological Disease
|
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) .
|
-
- HY-16023B
-
EM-343; (Rac)-EM-652
|
Estrogen Receptor/ERR
|
Cancer
|
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380 .
|
-
- HY-116699
-
|
PPAR
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions .
|
-
- HY-149917
-
|
PROTACs
Itk
|
Cancer
|
ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .
|
-
- HY-161405
-
|
Neuropeptide FF Receptor
Opioid Receptor
|
Neurological Disease
|
NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively .
|
-
- HY-W001187
-
Tempo
4 Publications Verification
|
Mitochondrial Metabolism
DNA/RNA Synthesis
Reactive Oxygen Species
|
Cancer
|
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
|
-
- HY-W001187R
-
|
Mitochondrial Metabolism
DNA/RNA Synthesis
Reactive Oxygen Species
|
Cancer
|
Tempo (Standard) is the analytical standard of Tempo. This product is intended for research and analytical applications. Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells [4].
|
-
- HY-161177
-
|
PROTACs
Ras
|
Infection
|
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .
|
-
- HY-153220A
-
|
PROTACs
Btk
|
Inflammation/Immunology
Cancer
|
(R)-NX-2127 ((R)-compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) . (R)-NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
|
-
- HY-144675
-
|
Histone Demethylase
|
Cancer
|
LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines .
|
-
- HY-144675A
-
|
Histone Demethylase
|
Cancer
|
LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines .
|
-
- HY-144673
-
-
- HY-131187
-
|
Ligands for Target Protein for PROTAC
|
Cancer
|
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1 . BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation .
|
-
- HY-117948
-
|
Others
|
Cancer
|
ML399 is a second-generation probe optimized for inhibitors of menin-mixed lineage leukemia (MLL) protein-protein interactions. Screening through the Molecular Library Probe Production Network (MLPCN) led to the discovery of several chemical classes, including piperidines, which successfully led to the generation of the first-generation probe ML227. However, metabolic instability, potency, and adjuvant pharmacological activity of ML227 were identified as limiting features. To enhance the utility of menin-MLL inhibitor probes for in vivo mechanistic studies, medicinal chemistry efforts were reinvigorated using a structure-based design approach, which ultimately led to the generation of the announced probe ML399. This study describes the structure-activity relationships and properties of this series of compounds.
|
-
- HY-146123
-
-
- HY-130178
-
|
Endogenous Metabolite
|
Infection
|
CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .
|
-
- HY-P10563
-
BHV-1100
|
CD38
|
Cancer
|
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
|
-
- HY-153220
-
|
PROTACs
Btk
|
Cancer
|
NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk) . NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells . NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
|
-
Cat. No. |
Product Name |
Type |
-
- HY-40226
-
|
Gene Sequencing and Synthesis
|
4-Amino-1-Boc-piperidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40014
-
1-Boc-Piperidine-3-carboxylic acid
|
Biochemical Assay Reagents
|
1-Boc-piperidine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40007
-
|
Biochemical Assay Reagents
|
1-Boc-4-(aminomethyl)piperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-43459
-
-
- HY-P10563
-
BHV-1100
|
CD38
|
Cancer
|
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W012748S
-
|
Piperidine-4-carboxamide-d9 is the deuterium labeled Piperidine-4-carboxamide[1].
|
-
-
- HY-150666S
-
|
1- (3,4- Dimethoxy-d6-benzoyl) piperidine is the deuterium labeled 1- (3,4- Dimethoxy-benzoyl) piperidine[1].
|
-
-
- HY-33540S
-
|
1-(Chlorocarbonyl)piperidine-d10 is the deuterium labeled 1-(Chlorocarbonyl)piperidine[1].
|
-
-
- HY-12760S
-
|
Indoramin-d5 is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent.
|
-
-
- HY-W697671S
-
|
Paroxetine-d6 (hydrochloride) is deuterium labeled trans-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride .
|
-
-
- HY-Z1430S
-
|
Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-158862
-
|
|
Cationic Lipids
|
BP Lipid 376 features a unique piperidine ionizable head group with a carbamate linkage to the lipid scaffold comprised of a linoleate ester and aliphatic acetal ester. This lipid may be used in the development of lipid nanoparticles for drug delivery.
|
-
- HY-158866
-
|
|
Cationic Lipids
|
BP Lipid 401 is derived from patent WO2020219876A1 (Example 102). BP Lipid 401 features a unique piperidine head group three carbon atoms in length. This compound can be useful for the building or modification of lipid nanoparticles.
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: