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Results for "

piperidines

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Linker (4) Adrenergic Receptor (1) Amino Acid Derivatives (1) Apoptosis (3) Autophagy (18) Bacterial (2) Biochemical Assay Reagents (6) Btk (3) CD38 (1) DNA/RNA Synthesis (2) Drug Derivative (5) Drug Intermediate (1) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (23) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Epoxide Hydrolase (1) Estrogen Receptor/ERR (1) GABA Receptor (1) GHSR (2) Glycosidase (1) Histone Demethylase (3) iGluR (1) Isotope-Labeled Compounds (6) Itk (1) Ligands for E3 Ligase (27) Ligands for Target Protein for PROTAC (3) mAChR (5) Mitochondrial Metabolism (2) Monoamine Oxidase (1) nAChR (2) Neuropeptide FF Receptor (1) Opioid Receptor (3) PARP (2) Phosphodiesterase (PDE) (1) Potassium Channel (3) PPAR (1) PROTAC Linkers (14) PROTACs (5) Ras (1) Reactive Oxygen Species (2) Target Protein Ligand-Linker Conjugates (2) Tyrosinase (1)
By Research Areas:	Cancer (89) Cardiovascular Disease (5) Endocrinology (2) Infection (3) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (23)

By Targets:

5-HT Receptor (4)

ADC Linker (4)

Adrenergic Receptor (1)

Amino Acid Derivatives (1)

Apoptosis (3)

Autophagy (18)

Bacterial (2)

Biochemical Assay Reagents (6)

Btk (3)

CD38 (1)

DNA/RNA Synthesis (2)

Drug Derivative (5)

Drug Intermediate (1)

Drug Metabolite (1)

E3 Ligase Ligand-Linker Conjugates (23)

Endogenous Metabolite (3)

Epigenetic Reader Domain (1)

Epoxide Hydrolase (1)

Estrogen Receptor/ERR (1)

GABA Receptor (1)

GHSR (2)

Glycosidase (1)

Histone Demethylase (3)

iGluR (1)

Isotope-Labeled Compounds (6)

Itk (1)

Ligands for E3 Ligase (27)

Ligands for Target Protein for PROTAC (3)

mAChR (5)

Mitochondrial Metabolism (2)

Monoamine Oxidase (1)

nAChR (2)

Neuropeptide FF Receptor (1)

Opioid Receptor (3)

PARP (2)

Phosphodiesterase (PDE) (1)

Potassium Channel (3)

PPAR (1)

PROTAC Linkers (14)

PROTACs (5)

Ras (1)

Reactive Oxygen Species (2)

Target Protein Ligand-Linker Conjugates (2)

Tyrosinase (1)

By Research Areas:

Cancer (89)

Cardiovascular Disease (5)

Endocrinology (2)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (2)

Neurological Disease (23)

136

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013727

UK-78282 hydrochloride	Potassium Channel	Inflammation/Immunology
UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC₅₀ of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil .

HY-100305

*Substituted piperidines-1*	GHSR Endogenous Metabolite	Endocrinology
Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.

HY-135670A

β-glycosidase-IN-1	Glycosidase	Metabolic Disease
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity .

HY-N3526

Calyxamine B	Others	Others
Calyxamine B is a piperidine alkaloid that can be isolated from Calyx podatypa .

HY-W012935

Piperidine-4-carbaldehyde Piperidine-4-carboxaldehyde	PROTAC Linkers	Cancer
Piperidine-4-carbaldehyde (Piperidine-4-carboxaldehyde) is a PROTAC Linker. Piperidine-4-carbaldehyde can be used to optimize combined with the target protein affinity, thus improve the PROTAC the molecular degradation efficiency. Piperidine-4-carbaldehyde can be used in the CDK2 PROTACs (HY-161708) .

HY-W012748S

Piperidine-4-carboxamide-d9	Isotope-Labeled Compounds	Others
Piperidine-4-carboxamide-d₉ is the deuterium labeled Piperidine-4-carboxamide[1].

HY-W584986

Thalidomide-(2)piperidine	Ligands for E3 Ligase	Cancer
Thalidomide-(2)piperidine (compound 9) is a potent E3 ligase ligand. Thalidomide-(2)piperidine can be used for synthesis of PROTACs .

HY-150666S

1-(3,4-Dimethoxy-d6-benzoyl)piperidine	Isotope-Labeled Compounds	Others
1- (3,4- Dimethoxy-d6-benzoyl) piperidine is the deuterium labeled 1- (3,4- Dimethoxy-benzoyl) piperidine[1].

HY-125828

1-(3,4-Dimethoxycinnamoyl)piperidine	Bacterial	Infection
1-(3,4-Dimethoxycinnamoyl)piperidine, a synthesized piperidine analog, possesses antimicrobial and antioxidant activity .

HY-33540S

*1-(Chlorocarbonyl)piperidine-d10*	Isotope-Labeled Compounds	Others
1-(Chlorocarbonyl)piperidine-d₁₀ is the deuterium labeled 1-(Chlorocarbonyl)piperidine[1].

HY-161202

*Thalidomide-piperidine-O-piperidine-C2-OH*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-piperidine-O-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-piperidine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-139116

Piperidine-4-sulfonic acid	GABA Receptor	Neurological Disease
Piperidine-4-sulfonic acid is a potent GABA agonist with an IC₅₀ of 0.034 μM for the inhibition of the binding of H-GABA .

HY-169050

Thalidomide-piperidine	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-piperidine can be used to synthesize SMART1 (HY-W998345) .

HY-W251284A

3-Anilinopiperidine dihydrochloride	Drug Derivative	Neurological Disease
3-Anilinopiperidine dihydrochloride is a piperidine.

HY-138783A

*Thalidomide-Piperazine-Piperidine* hydrochloride**	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-115378

1-(3,5-Dimethylphenyl)piperazine	Drug Derivative	Neurological Disease
1-(3,5-Dimethylphenyl)piperazine is a piperidine compound.

HY-168203

*Thalidomide-piperidine-O-Ph-NH2*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidine-O-Ph-NH2 is the conjugate of E3 ligase and linker. Thalidomide-piperidine-O-Ph-NH2 can be used for synthesis of PROTAC degrader MJP6412 (HY-168201) .

HY-168217

*Thalidomide-piperazine-piperidine-2-F-Ph-CHO*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperazine-piperidine-2-F-Ph-CHO is a E3 ligase ligand-linker conjugate, which is consisted of a Thalidomide (HY-14658) and a linker Boc-Piperazine-piperidine-2-F-Ph-CHO (HY-168218). Thalidomide-piperazine-piperidine-2-F-Ph-CHO is utilized for synthesis of PROTAC molecule YDR1 (HY-168215) .

HY-168039

*Boc-NH-Piperidine-C5-OH*	PROTAC Linkers	Cancer
Boc-NH-Piperidine-C5-OH is a PROTAC linker. Boc-NH-Piperidine-C5-OH can be used in the synthesis of PROTAC PIN1 degrader-1 (HY-168037) .

HY-168231

*trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH*	PROTAC Linkers	Cancer
trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH is a PROTAC linker. trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .

HY-130983

*N-piperidine* Ibrutinib hydrochloride**	Btk Ligands for Target Protein for PROTAC	Cancer
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC₅₀s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively . N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC₅₀ of 7.9 nM .

HY-169489

*2F-Pyrimidine-piperidine-spiro[3.3]heptane-acid*	PROTAC Linkers	Cancer
2F-Pyrimidine-piperidine-spiro[3.3]heptane-acid is a PROTAC linker. 2F-Pyrimidine-piperidine-spiro[3.3]heptane-acid can be used in the synthesis of PROTACs (e.g. HY-169272) .

HY-121964

*cis-Piperidine-2,3-dicarboxylic acid*	iGluR	Neurological Disease
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .

HY-163237

*Thalidomide-piperidine-O-azetidineethanol*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-piperidine-O-azetidineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-azetidineethanol can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-E70249

3-Hydroxydecanoyl-CoA S-[(3S)-3-Hydroxydecanoate]-CoA	Endogenous Metabolite	Others
3-Hydroxydecanoyl-CoA (S-[(3S)-3-Hydroxydecanoate]-CoA) is a coenzyme, which is the main substrate for the synthesis enzyme PhaC1 of 1-benzyloxycarbonyl piperidine-4-yl acetic acid (PHA) in P. aeruginosa .

HY-163232

*Phthalimidinoglutarimide-piperidine-NH-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
Phthalimidinoglutarimide-piperidine-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-piperidine-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-12760S

Indoramin-d5 Indoramine d₅; Wy-21901 d₅	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Indoramin-d₅ is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent.

HY-18373

UNC1079	Epigenetic Reader Domain	Cancer
UNC1079 is a piperidine analog of UNC1021, structurally similar but with lower efficacy as an inhibitor.

HY-168227

*trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc*	PROTAC Linkers	Cancer
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc is a PROTAC linker. trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc can be used in the synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225) .

HY-168040

*Thalidomide-O-C5-piperidine-NH-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-O-C5-piperidine-NH-Boc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-O-C5-piperidine-NH-Boc can be used to synthesize PROTAC PIN1 degrader-1 (HY-168037) .

HY-163236

*Thalidomide-piperidine-O-azetidine-acetic acid*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-piperidine-O-azetidine-acetic acid is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-azetidine-acetic acid can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163234

*Phthalimidinoglutarimide-piperidine-NH2*	E3 Ligase Ligand-Linker Conjugates	Cancer
Phthalimidinoglutarimide-piperidine-NH2 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-piperidine-NH2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-168272

(3S)Lenalidomide-piperazine-C-piperidine	E3 Ligase Ligand-Linker Conjugates	Cancer
(3S)Lenalidomide-piperazine-C-piperidine is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). (3S)Lenalidomide-piperazine-C-piperidine can be used to synthesize PROTAC PROTAC ER Degrader-11 (HY-168270) .

HY-168389

*Thalidomide-piperidine-C2-piperazine-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidine-C2-piperazine-Boc is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-130639) based cereblon ligand and a linker used in PROTAC technology. Thalidomide-piperidine-C2-piperazine-Boc can be used for synthesis of PROTACs .

HY-W200249

Meta-methyl 4-anilino-1-Boc-piperidine	Drug Derivative	Neurological Disease
Meta-methyl 4-anilino-1-Boc-piperidine is a precursor in the synthesis of a compound.

HY-150341

Ortho-methyl 4-anilino-1-boc-piperidine	Opioid Receptor	Neurological Disease
Ortho-methyl 4-anilino-1-boc-piperidine is a precursor in the synthesis of a compound.

HY-W399538

Para-methyl 4-anilino-1-boc-piperidine	Drug Derivative	Neurological Disease
Para-methyl 4-anilino-1-boc-piperidine is a precursor in the synthesis of a compound.

HY-163922

*CRBN ligand-1-piperidine-Me*	E3 Ligase Ligand-Linker Conjugates	Cancer
CRBN ligand-1-piperidine-Me is an E3 ligase ligand-linker conjugate.

HY-161198

*Thalidomide-azetidine-pyrrolidine-C-piperidine-C-boc*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-azetidine-pyrrolidine-C-piperidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-pyrrolidine-C-piperidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-161195

*Deoxy-thalidomide-piperidine-C-piperazine-C-boc*	Ligands for E3 Ligase Autophagy	Cancer
Deoxy-thalidomide-piperidine-C-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-168388

Piperidine-C2-piperazine-Boc	PROTAC Linkers	Cancer
Piperidine-C2-piperazine-Boc is a PROTAC linker that can be used in the synthesis of PROTACs .

HY-W904851

*Boc-Piperidine-piperazine-Cbz*	PROTAC Linkers	Cancer
Boc-Piperidine-piperazine-Cbz is a PROTAC linker that can be used in the synthesis of ZLC491 (HY-168162) .

HY-168239

*Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates). Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph can be used for the synthesis of PROTAC SMARCA2 degrader-28 (HY-168236) .

HY-114791

Lobelanidine	nAChR	Neurological Disease
Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC₅₀ of 2.8 and 8.2 μM .

HY-43459

*(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine*	Amino Acid Derivatives	Others
(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine is a leucine derivative .

HY-161199

*Thalidomide-azetidine-pyrrolidine-C-piperidine-C2-OH*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-azetidine-pyrrolidine-C-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-pyrrolidine-C-piperidine-C2-OH can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-159684

*3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin*	PROTAC Linkers	Cancer
3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker. 3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin can be used in the synthesis PROTAC SMARCA2/4-degrader-30 (HY-162748) .

HY-161184

*Deoxy-thalidomide-piperidine-C-piperazine-C2-OH*	Ligands for E3 Ligase Autophagy	Cancer
Deoxy-thalidomide-piperidine-C-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-161186

*Thalidomide-piperidine-C-azetidine-C2-O-C-boc*	Ligands for E3 Ligase Autophagy	Cancer
Thalidomide-piperidine-C-azetidine-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-C-azetidine-C2-O-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-161185

*Thalidomide-piperidine-O-azetidine-boc*	Ligands for E3 Ligase	Cancer
Thalidomide-piperidine-O-azetidine-boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

Cat. No.	Product Name	Target	Research Area

HY-43459

*(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine*	Amino Acid Derivatives	Others
(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine is a leucine derivative .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3526

Calyxamine B	Structural Classification Alkaloids Piperidine Alkaloids Source classification Marine natural products Sponge	Others
Calyxamine B is a piperidine alkaloid that can be isolated from Calyx podatypa .

HY-114791

Lobelanidine	Structural Classification Alkaloids Lobelia tupa L. Other Alkaloids Source classification Campanulaceae Plants	nAChR
Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC₅₀ of 2.8 and 8.2 μM .

HY-121229A

(±)-Coniine 2-Propylpiperidine	Alkaloids Piperidine Alkaloids Structural Classification Tsuga chinensis (Franch.) Pritz. Classification of Application Fields Pinaceae Source classification Other Diseases Plants Disease Research Fields	nAChR
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

Cat. No.	Product Name	Chemical Structure

HY-W012748S

Piperidine-4-carboxamide-d9
Piperidine-4-carboxamide-d₉ is the deuterium labeled Piperidine-4-carboxamide[1].

HY-150666S

1-(3,4-Dimethoxy-d6-benzoyl)piperidine
1- (3,4- Dimethoxy-d6-benzoyl) piperidine is the deuterium labeled 1- (3,4- Dimethoxy-benzoyl) piperidine[1].

HY-33540S

*1-(Chlorocarbonyl)piperidine-d10*
1-(Chlorocarbonyl)piperidine-d₁₀ is the deuterium labeled 1-(Chlorocarbonyl)piperidine[1].

HY-12760S

Indoramin-d5
Indoramin-d₅ is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent.

HY-W697671S

Paroxetine-d6 hydrochloride
Paroxetine-d₆ (hydrochloride) is deuterium labeled trans-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride .

HY-Z1430S

(3R,4S)-Paroxetine-d4 hydrochloride
Paroxetine EP impurity D-d₄ (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).

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