Search Result
Results for "
polycyclic
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W013570
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Others
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Others
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Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .
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- HY-W026772
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Fluorescent Dye
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Others
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Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes .
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- HY-W014075
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Endogenous Metabolite
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Metabolic Disease
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1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .
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- HY-W013570R
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Others
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Others
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Acenaphthylene (Standard) is the analytical standard of Acenaphthylene. This product is intended for research and analytical applications. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .
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- HY-N11501
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STAT
Apoptosis
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Cancer
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7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .
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- HY-162541
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Glucosidase
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Metabolic Disease
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α-Glucosidase-IN-64 (compound 10) is a potent α-glucosidase inhibitor with an IC50 value of 8.62 µM. α-Glucosidase-IN-64 is a polycyclic polyprenylated acylphloroglucinol that can be isolated from hypericum beanii .
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- HY-W026772R
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Fluorescent Dye
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Others
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Fluorene (Standard) is the analytical standard of Fluorene. This product is intended for research and analytical applications. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative?can be used as a precursor to fluorene-based dyes .
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- HY-W014075R
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Endogenous Metabolite
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Metabolic Disease
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1-Hydroxypyrene (Standard) is the analytical standard of 1-Hydroxypyrene. This product is intended for research and analytical applications. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .
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- HY-143770
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .
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- HY-N2427
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Others
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Others
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Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
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- HY-125630
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Others
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Others
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Decacyclene is a large polycyclic aromatic hydrocarbon with a triple symmetry. Decacyclene is a three-blade molecular propeller in the solid state, and crystal structure analysis shows that the molecule has a non-planar twisted form, and the crystal is chiral, which may correspond to the enantiomers of the Decacyclene propeller. Decacyclene can be used for research in chemical synthesis and materials science .
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- HY-W013053
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DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
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DNA/RNA Synthesis
Apoptosis
MDM-2/p53
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Cancer
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Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
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- HY-N2427R
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Others
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Others
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Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
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- HY-W013053R
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DNA/RNA Synthesis
Apoptosis
MDM-2/p53
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Cancer
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Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
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- HY-111441
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Chrysene-1,4-dione
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Aryl Hydrocarbon Receptor
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Cancer
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1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
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- HY-121107
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Others
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Cancer
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Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .
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- HY-W011845
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7,12-DMBA; 7,12-Dimethylbenzanthracene
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Others
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Cancer
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DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
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- HY-W007692
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2-Acetylpyrazine
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Others
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Others
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Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
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- HY-121107S
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Isotope-Labeled Compounds
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Cancer
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Chrysene-d12 is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].
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- HY-121360
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DNA/RNA Synthesis
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Others
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Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. It is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA .
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- HY-W441021
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Liposome
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Others
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DSPE-Pyrene is a phospholipid molecule with polycyclic aromatic hydrocarbon, and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Pyrene is a fluorescent probe whose spectrum is sensitive to the polarity of its environment.
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- HY-B1727
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Apoptosis
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Inflammation/Immunology
Cancer
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Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
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- HY-136301
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Others
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Inflammation/Immunology
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Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment .
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- HY-121107R
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Others
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Cancer
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Chrysene (Standard) is the analytical standard of Chrysene. This product is intended for research and analytical applications. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .
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- HY-W026772S
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Fluorescent Dye
Isotope-Labeled Compounds
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Others
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Fluorene-d10 is the deuterium labeled Fluorene. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes[1].
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- HY-W013570S
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Acenaphthylene-d8
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Isotope-Labeled Compounds
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Others
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Acenaphthylene-d8 is the deuterium labeled Acenaphthylene[1]. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[2].
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- HY-156228
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Others
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Cancer
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RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells .
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- HY-N12527
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NF-κB
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Others
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Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .
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- HY-N0823
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(+)-Lithospermic acid
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Others
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Inflammation/Immunology
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Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
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- HY-B1727S
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Isotope-Labeled Compounds
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Inflammation/Immunology
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Phenanthrene-d10 is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices[1]. Phenanthrene induces oxidative stress and inflammation[2].
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- HY-W014075S
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Endogenous Metabolite
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Metabolic Disease
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1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].
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- HY-111450
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Aryl Hydrocarbon Receptor
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Cancer
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CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .
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- HY-W089800S
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trans-2-Nonen-1-al-d2
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Biochemical Assay Reagents
Isotope-Labeled Compounds
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Others
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trans-2-Nonenal-d2 is deuterated labeled Acetylpyrazine (HY-W007692). Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
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- HY-B1727R
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Apoptosis
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Inflammation/Immunology
Cancer
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Phenanthrene (Standard) is the analytical standard of Phenanthrene. This product is intended for research and analytical applications. Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
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- HY-P10033
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Ser/Thr Protease
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Others
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SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.
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- HY-121014
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Others
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Cancer
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Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.
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- HY-W127705
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Fluorescent Dye
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Others
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Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .
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- HY-N0823R
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Others
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Inflammation/Immunology
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Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
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- HY-109542R
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Others
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Metabolic Disease
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Cyclopenthiazide (Standard) is the analytical standard of Cyclopenthiazide. This product is intended for research and analytical applications. Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .
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- HY-109542
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Others
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Metabolic Disease
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Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .
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- HY-P10027
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Antibiotic
Bacterial
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Infection
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Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
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- HY-P10027A
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Antibiotic
Bacterial
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Infection
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Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
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- HY-103609
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Benzo[def]phenanthrene
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Biochemical Assay Reagents
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Others
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Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
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- HY-P1206
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Somatostatin Receptor
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Neurological Disease
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CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
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- HY-103609R
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Biochemical Assay Reagents
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Others
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Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
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Cat. No. |
Product Name |
Type |
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- HY-W127705
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Fluorescent Dyes/Probes
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Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .
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- HY-103609
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Benzo[def]phenanthrene
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Dyes
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Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
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- HY-103609R
-
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Dyes
|
Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
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Cat. No. |
Product Name |
Type |
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- HY-W441021
-
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Drug Delivery
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DSPE-Pyrene is a phospholipid molecule with polycyclic aromatic hydrocarbon, and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Pyrene is a fluorescent probe whose spectrum is sensitive to the polarity of its environment.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P3193A
-
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Peptides
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Others
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Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .
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- HY-P10033
-
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Ser/Thr Protease
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Others
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SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.
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- HY-P10027A
-
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Antibiotic
Bacterial
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Infection
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Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
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- HY-P1206
-
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Somatostatin Receptor
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Neurological Disease
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CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
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- HY-P3193
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Peptides
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Others
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Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .
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- HY-P4102
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Peptides
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Cancer
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Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .
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- HY-P10027
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Antibiotic
Bacterial
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Infection
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Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-121107S
-
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Chrysene-d12 is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].
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- HY-B1727S
-
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Phenanthrene-d10 is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices[1]. Phenanthrene induces oxidative stress and inflammation[2].
|
-
-
- HY-W013570S
-
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Acenaphthylene-d8 is the deuterium labeled Acenaphthylene[1]. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[2].
|
-
-
- HY-W014075S
-
|
1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].
|
-
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- HY-W089800S
-
|
trans-2-Nonenal-d2 is deuterated labeled Acetylpyrazine (HY-W007692). Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
|
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Cat. No. |
Product Name |
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Classification |
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- HY-W441021
-
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Phospholipids
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DSPE-Pyrene is a phospholipid molecule with polycyclic aromatic hydrocarbon, and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Pyrene is a fluorescent probe whose spectrum is sensitive to the polarity of its environment.
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