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Results for "

polyketide

" in MedChemExpress (MCE) Product Catalog:

54

Inhibitors & Agonists

34

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139594
    Polyketide synthase 13-IN-1

    		Others Infection Inflammation/Immunology
    Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor .
    Polyketide synthase 13-IN-1
  • HY-139595
    Polyketide synthase 13-IN-2

    		Bacterial Infection Inflammation/Immunology
    Polyketide synthase 13-IN-2 (comp 42) is a polyketide synthase 13 inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .
    Polyketide synthase 13-IN-2
  • HY-139596
    Polyketide synthase 13-IN-3

    		Others Infection Inflammation/Immunology
    Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv .
    Polyketide synthase 13-IN-3
  • HY-N15188
    hemi-Oxanthromicin A

    		Endogenous Metabolite Others
    hemi-Oxanthromicin A is a polyketide which can be extracted from Streptomyces .
    hemi-Oxanthromicin A
  • HY-N10302
    Bipolamine G

    		Bacterial Endogenous Metabolite Infection
    Bipolamine G is an antibacterial polyketide alkaloid .
    Bipolamine G
  • HY-W748023
    Cryptosporiopsin A

    		Fungal Inflammation/Immunology
    Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola .
    Cryptosporiopsin A
  • HY-146162
    Colletotrichalactones A

    		Endogenous Metabolite Cancer
    Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC50 of 35.06 µM .
    Colletotrichalactones A
  • HY-116479
    Citromycetin

    		Bacterial Others
    Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .
    Citromycetin
  • HY-100710
    Epothilone C

    		Endogenous Metabolite Cancer
    Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research .
    Epothilone C
  • HY-121291
    Aureothin

    		HIV Infection
    Aureothin, is a natural polyketide, is a HIV inhibitor with an IC50 of 5.3 nM. Aureothin is a microbial biolarvicide .
    Aureothin
  • HY-N10293
    Monaschromone

    		Fungal Endogenous Metabolite Infection
    Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM .
    Monaschromone
  • HY-121699
    Kibdelone B

    		Biochemical Assay Reagents Infection Metabolic Disease
    Kibdelone B (Compound 2) is a bioactive heterocyclic polyketide that is found in Kibdelosporangium sp. Kibdelone B and C undergo a facile equilibration to Kibdelones A-C under mild conditions .
    Kibdelone B
  • HY-W775186
    Tolprocarb

    		Fungal Infection
    Tolprocarb is an oomyces fungicide, which has a strong inhibitory effect on rice blast fungus Magnaporthe grisea by inhibiting polyketide synthase in melanin synthesis pathway .
    Tolprocarb
  • HY-N12657
    Retinestatin

    		Others Neurological Disease
    Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP + (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .
    Retinestatin
  • HY-130307
    Rubrofusarin

    		Bacterial Neurological Disease Inflammation/Immunology Cancer
    Rubrofusarin is an orange polyketide pigment from Fusarium graminearum . Rubrofusarin is also an active ingredient of the Cassia species and ameliorates chronic restraint stress (CRS) -induced depressive symptoms through PI3K/Akt signaling. Rubrofusarin has anticancer, antibacterial, and antioxidant effects .
    Rubrofusarin
  • HY-126679
    Apoptolidin

    		ATP Synthase Apoptosis Cancer
    Apoptolidin is a polyketide isolated from Nocardiopsis?bacteria . Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells .
    Apoptolidin
  • HY-111009
    Swinholide A

    		Fungal Infection
    Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .
    Swinholide A
  • HY-121300
    Kendomycin

    (-)-TAN2162

    		 Antibiotic Bacterial Endothelin Receptor CGRP Receptor Infection Cancer
    Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent .
    Kendomycin
  • HY-N10561
    Wychimicin A

    		Bacterial Infection
    Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
    Wychimicin A
  • HY-N10560
    Wychimicin C

    		Bacterial Infection
    Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
    Wychimicin C
  • HY-19828
    Herboxidiene

    GEX1A

    		 DNA/RNA Synthesis Cancer
    Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .
    Herboxidiene
  • HY-138140
    Desertomycin A

    		Others Others
    Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .
    Desertomycin A
  • HY-B0767
    Spinosyn A

    		Insecticide Others
    Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide .
    Spinosyn A
  • HY-N10298
    Massarilactone H

    		Influenza Virus Infection
    Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC50 of 8.18 µM .
    Massarilactone H
  • HY-107417
    Hypothemycin

    		VEGFR MEK FLT3 PDGFR ERK Cancer
    Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively .
    Hypothemycin
  • HY-N10449
    Resistomycin

    		Antibiotic Apoptosis Bacterial Cancer
    Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .
    Resistomycin
  • HY-121061
    Abikoviromycin

    		Others Infection
    Abikoviromycin is an inhibitor of polyketide synthase PKS1 of C. lagenarium and can be isolated from Streptomyces .
    Abikoviromycin
  • HY-117740
    Heronamide C

    		Others Others
    Heronamide C is a polyketide macrolactam isolated from marine Streptomyces that has the activity of producing reversible non-cytotoxic effects on mammalian cell morphology.
    Heronamide C
  • HY-N13156
    Amycolatopsin B

    		Fungal Infection
    Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494 .
    Amycolatopsin B
  • HY-B0767R
    Spinosyn A (Standard)

    		Others Others
    Spinosyn A (Standard) is the analytical standard of Spinosyn A. This product is intended for research and analytical applications. Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide .
    Spinosyn A (Standard)
  • HY-112514
    1,3,6,8-Tetrahydroxynaphthalene
    1 Publications Verification

    1,3,6,8-THN; T4HN

    		 Drug Intermediate Others
    1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin .
    1,3,6,8-Tetrahydroxynaphthalene
  • HY-N10362
    Ellipyrone B

    		Dipeptidyl Peptidase Metabolic Disease
    Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC50=0.48 mM) .
    Ellipyrone B
  • HY-N4301
    Monensin B

    		Others Others
    Monensin B is a polyketide produced by Streptomyces cinnamonensis. Fermentations of Streptomyces cinnamonensis produce a mixture of Monensin A and Monensin B in a ratio dependent upon the relative concentrations of ethylmalonyl-CoA and methylmalonyl-CoA .
    Monensin B
  • HY-121459
    Neoantimycin

    		HSP Ras
    Neoantimycin is a GRP78/BiP and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system .
    Neoantimycin
  • HY-130043
    11-O-Methylpseurotin A

    		Others Inflammation/Immunology
    11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain .
    11-O-Methylpseurotin A
  • HY-N11667
    18-O-Demethylpederin

    		Others Infection Cancer
    18-O-Demethylpederin is a pederin analogue. Pederin is a natural polyketide compound extracted from Paederus for the first time. It is a non-protein insect toxin with a broad spectrum of biological activities, including antibacterial, antiviral, and antitumor .
    18-O-Demethylpederin
  • HY-N10292
    Chaetosemin J

    		Fungal Endogenous Metabolite Infection
    Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .
    Chaetosemin J
  • HY-N6777
    Penicillic acid
    1 Publications Verification

    		 Caspase Bacterial Apoptosis Antibiotic Infection Cancer
    Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .
    Penicillic acid
  • HY-116838
    TAM-16

    		Bacterial Infection
    TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel .
    TAM-16
  • HY-W663230
    Eugenitin

    		Parasite Infection
    Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
    Eugenitin
  • HY-13557
    Ascomycin
    Maximum Cited Publications
    6 Publications Verification

    Immunomycin; FR-900520; FK520

    		 FKBP Parasite Fungal Antibiotic Infection Neurological Disease Inflammation/Immunology
    Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
    Ascomycin
  • HY-122534
    Mensacarcin

    		Mitochondrial Metabolism ADC Cytotoxin Apoptosis Cancer
    Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
    Mensacarcin
  • HY-117145
    Thiophene-2

    		Bacterial Infection
    Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .
    Thiophene-2
  • HY-117760
    Spirolaxine

    		Bacterial Endogenous Metabolite Infection
    Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .
    Spirolaxine
  • HY-12546
    Brevetoxin B

    Brevetoxin-2; PbTx-2

    		 Sodium Channel Neurological Disease
    Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.
    Brevetoxin B
  • HY-121003
    Aspyrone

    		Fungal Parasite Infection
    Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities. It is active against a panel of 13 fungi when used at a concentration of 20 μg/mL and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.
    Aspyrone
  • HY-170575
    Pks13-IN-1

    		Bacterial Infection
    Pks13-IN-1 (Compound 44) is an orally active inhibitor for Mycobacterium tuberculosis Polyketide synthase 13 (Pks13). Pks13-IN-1 inhibits M. tuberculosis strain H37Rv with a MIC of 0.07 μM. Pks13-IN-1 exhibits antibacterial efficacy in mouse model .
    Pks13-IN-1
  • HY-130757
    Remisporine B

    		Endogenous Metabolite Inflammation/Immunology
    Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC50 of 30.1 µg/mL and 32.4 µg/mL .
    Remisporine B
  • HY-119894
    Althiomycin

    NSC 102809

    		 Antibiotic Infection
    Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.
    Althiomycin
  • HY-W073762
    FBnG

    		Biochemical Assay Reagents Cancer
    FBnG is a component of non-ribosomal peptide synthetase/polyketide synthase (NRPS/PKS), which is associated with the biosynthesis of fabrubactin (FBN). FBnG can be used for synthesis of AUTAC4 as part of FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 (HY-150408) .
    FBnG

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