Search Result

Results for "

replacement

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (3) CRISPR/Cas9 (2) DNA/RNA Synthesis (3) Endogenous Metabolite (9) Estrogen Receptor/ERR (5) Factor Xa (2) Fluorescent Dye (2) Fungal (2) HIV (1) Isotope-Labeled Compounds (2) Phosphatase (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (8) Infection (4) Inflammation/Immunology (1) Metabolic Disease (6) Neurological Disease (1)
Oligonucleotides:	CpG ODNs (1) Chelating Agents (1) pH Modifiers (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148140

Cross-linked dextran G 25 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .

HY-116865

Equilenin	Endogenous Metabolite	Endocrinology Cancer
Equilenin is a B-ring unsaturated estrogen and one of the main ingredients in Premarin, a drug commonly used in estrogen replacement therapy. Equilenin can bind to estrogen receptors in the body and exert effects similar to endogenous estrogen. Equilenin can be used in estrogen replacement therapy and breast cancer research .

HY-W021448

Glycocyamine Guanidinoacetic acid	Endogenous Metabolite	Others
Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.

HY-N3018

Isomaltose 6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose	Endogenous Metabolite	Metabolic Disease
Isomaltose is composed of two glucose units and suitable as a non-cariogenic sucrose replacement and is favorable in products for diabetics and prediabetic dispositions.

HY-153592

Therapeutic agent-1	Others	Others
Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy .

HY-B0672

Estradiol valerate β-Estradiol 17-valerate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-W021448S

Glycocyamine-d2 Guanidinoacetic acid-d₂	Endogenous Metabolite	Others
Glycocyamine-d₂ is the deuterium labeled Glycocyamine. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.

HY-135253

GR122222X	DNA/RNA Synthesis	Others
GR122222X is a DNA gyrase B protein inhibitor related to the cyclothiidine structure, which allows the crystallization of this protein fragment for molecular replacement studies.

HY-146753

HIV-1 inhibitor-20	HIV	Infection
HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles .

HY-10269

LY-517717	Factor Xa	Cardiovascular Disease
LY-517717 is a potent and orally active FXa inhibitor. LY-517717 shows antithrombotic and anticoagulant activity. LY-517717 has the potential for the research of venous thromboembolism after hip or knee replacement .

HY-168322

2-Hydroxy nile red trifluoromethanesulfonate	Fluorescent Dye	Others
2-Hydroxy nile red trifluoromethanesulfonate is a fluorescent probe, that enters into oligodeoxyribonucleic acid as a nucleotide replacement. 2-Hydroxy nile red trifluoromethanesulfonate can be used as a DNA probe for detecting the polar changes in tumor microenvironments .

HY-B0672S

Estradiol valerianate-d9	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate-d₉ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B0672S1

Estradiol valerianate-d4 β-Estradiol 17-valerate-d₄	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate-d₄ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-W021448S1

Glycocyamine-15N,13C2	Endogenous Metabolite	Others
Glycocyamine- ¹⁵N, ¹³C₂ is the ¹³C and ¹⁵N labeled Glycocyamine[1]. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird[2].

HY-E70216

Bsu DNA polymerase, Large fragment	Others	Others
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .

HY-Y0308

Disodium phosphate	Biochemical Assay Reagents	Others
Disodium phosphate is commonly used as a food additive, buffer and laboratory reagent. Disodium phosphate has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions.

HY-B0672R

Estradiol valerate (Standard) β-Estradiol 17-valerate (Standard)	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate (Standard) is the analytical standard of Estradiol valerianate. This product is intended for research and analytical applications. Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-160230

ssRNA41 sodium	Toll-like Receptor (TLR)	Infection
ssRNA41 sodium is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine. ssRNA41 sodium is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 .

HY-108786

Asfotase alfa ENB-0040	Phosphatase	Metabolic Disease
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^?/? knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

HY-124882

Dienestrol diacetate	Estrogen Receptor/ERR	Endocrinology
Dienestrol diacetate is a synthetic nonsteroidal phenolic compound with estrogenic activity. Dienestrol diacetate can mimic the effects of estrogen in vivo, affecting the reproductive system and other related biological processes. Dienestrol diacetate is being studied for the inhibition of hormone-related diseases, such as estrogen deficiency. Dienestrol diacetate's potential applications also include possible use in hormone replacement therapy .

HY-121855

1-Monoelaidin Glycerol 1-monoelaidate; α-Monoelaidin	Biochemical Assay Reagents	Others
Monoeladin is an ester derivative of glycerin and oleic acid, which are commonly found in various vegetable and animal fats. Monoeladin has unique chemical properties that make it an important intermediate in the biosynthesis of other lipid molecules, especially in the formation of triglycerides and phospholipids. It also plays a role in food science as a partial replacement for saturated fat, which has been linked to an increased risk of heart disease.

HY-141591

CYT296	Others	Others
CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .

HY-160231

ssRNA42 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-W040971

Creosol 2-Methoxy-4-methylphenol	Endogenous Metabolite	Metabolic Disease
Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass .

HY-W040971R

Creosol (Standard)	Endogenous Metabolite	Metabolic Disease
Creosol (Standard) is the analytical standard of Creosol. This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass .

HY-D2160

AF 647 carboxylic acid	Fluorescent Dye	Others
AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye, with an excitation wavelength (λ_ex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). The maximum excitation wavelength is 647 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling .

HY-160281

CCD-2	Others	Metabolic Disease
CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies .

HY-118409

VPC-3033	Androgen Receptor	Endocrinology Cancer
VPC-3033 is an androgen receptor antagonist. VPC-3033 has a strong androgen DHT replacement potency (IC₅₀: 0.625-2.5 μM), can effectively inhibit androgen receptor transcriptional activity (IC₅₀=0.3 μM), and has a strong androgen receptor degradation ability. In addition, VPC-3033 exhibits significant anti-androgen receptor activity against prostate cancer cells resistant to Enzalutamide (HY-70002) .

HY-125856A

Milvexian TFA BMS-986177 TFA; JNJ-70033093 TFA	Factor Xa	Cardiovascular Disease
Milvexian TFA (BMS-986177 TFA) is a factor XIa inhibitor with biological activity to prevent venous thromboembolism. Milvexian TFA was effective in reducing the occurrence of venous thromboembolism in patients undergoing knee replacement surgery. Milvexian TFA has good selectivity and shows significant inhibitory effects on plasma kallikrein and trypsin. Milvexian TFA has a bioavailability of 32%, which means it has a high absorption rate in the body. Milvexian TFA showed a relatively low risk of bleeding in clinical trials .

HY-W012848

1-Phenylethanamine DL-α-Methylbenzylamine	Endogenous Metabolite	Neurological Disease Cancer
1-Phenylethanamine is a potential central nervous system stimulant and a related compound of β-phenylethylamine. Due to the replacement of its benzene ring with an indole group, its brain glycogenolytic activity is significantly reduced. Therefore, 1-Phenylethanamine can be used to study the impact of the chemical structure of phenylethylamine derivatives on central nervous system activity. In addition, 1-Phenylethanamine can also be used to synthesize the tyrosine kinase (tyrosine kinase) inhibitor CLM3 (HY-164413) .

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-107845

SCR7 pyrazine Maximum Cited Publications 12 Publications Verification	CRISPR/Cas9 DNA/RNA Synthesis Apoptosis	Cancer
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

HY-153264

TAS2R14 agonist-1	Others	Others
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

HY-12742

SCR7	DNA/RNA Synthesis CRISPR/Cas9 Apoptosis	Cancer
SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine (HY-107845). SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

HY-121465

Stearoyl Serotonin	Endogenous Metabolite	Metabolic Disease
Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC₅₀=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC₅₀ > 50 μM).

Cat. No.	Product Name	Type

HY-D2160

AF 647 carboxylic acid	Fluorescent Dyes/Probes
AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye, with an excitation wavelength (λ_ex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). The maximum excitation wavelength is 647 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling .

AF 647 carboxylic acid

Fluorescent Dyes/Probes

AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye, with an excitation wavelength (λ_ex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). The maximum excitation wavelength is 647 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling .

Cat. No.	Product Name	Type

HY-Y0308D

Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 Disodium hydrogen phosphate, meets analytical specification of Ph. Eur. BP USP FCC E339	Buffer Reagents
Sodium phosphate dibasic is commonly used as a food additive, buffer and laboratory reagent. Sodium phosphate dibasic has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions .

HY-121855

1-Monoelaidin Glycerol 1-monoelaidate; α-Monoelaidin	Drug Delivery
Monoeladin is an ester derivative of glycerin and oleic acid, which are commonly found in various vegetable and animal fats. Monoeladin has unique chemical properties that make it an important intermediate in the biosynthesis of other lipid molecules, especially in the formation of triglycerides and phospholipids. It also plays a role in food science as a partial replacement for saturated fat, which has been linked to an increased risk of heart disease.

1-Monoelaidin

Glycerol 1-monoelaidate; α-Monoelaidin

Drug Delivery

Monoeladin is an ester derivative of glycerin and oleic acid, which are commonly found in various vegetable and animal fats. Monoeladin has unique chemical properties that make it an important intermediate in the biosynthesis of other lipid molecules, especially in the formation of triglycerides and phospholipids. It also plays a role in food science as a partial replacement for saturated fat, which has been linked to an increased risk of heart disease.

Cat. No.	Product Name	Target	Research Area