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Results for "

trafficking

" in MedChemExpress (MCE) Product Catalog:

54

Inhibitors & Agonists

3

Fluorescent Dye

4

Biochemical Assay Reagents

8

Peptides

2

Inhibitory Antibodies

2

Natural
Products

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158002
    IDOR-4

    		CFTR Inflammation/Immunology
    IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .
    IDOR-4
  • HY-D1438
    RH 414

    		Fluorescent Dye Others
    RH 414 is the styryl pyridinium dye. RH 414 can be used for optical monitoring of synaptic vesicle membrane trafficking .
    RH 414
  • HY-122571
    Retro-2
    1 Publications Verification

    		 Filovirus Parasite Autophagy Infection Cancer
    Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy .
    Retro-2
  • HY-110174
    NAB2

    		Others Neurological Disease
    NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a agentgable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking .
    NAB2
  • HY-107572
    PD 128042

    CI 976

    		 Acyltransferase Metabolic Disease
    PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .
    PD 128042
  • HY-P9947
    Efalizumab

    		Integrin Others
    Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research .
    Efalizumab
  • HY-147087
    YSK 05

    		Liposome Cancer
    YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
    YSK 05
  • HY-125168
    EGA
    1 Publications Verification

    		 Others Infection Inflammation/Immunology
    EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and virus[1].
    EGA
  • HY-139407
    3-C12-NBD-cholesterol

    3-Dodecanoyl-NBD-cholesterol

    		 Fluorescent Dye Others
    3-C12-NBD-cholesterol is a fluorescent cholesterol analog that can be used for measuring membrane and intracellular trafficking dynamics .
    3-C12-NBD-cholesterol
  • HY-101112
    Okicenone

    		HuR Inflammation/Immunology
    Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation .
    Okicenone
  • HY-13262
    Lumacaftor
    10+ Cited Publications

    VX-809; VRT 826809

    		 CFTR Autophagy Inflammation/Immunology
    Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
    Lumacaftor
  • HY-131682
    3-C6-NBD-cholesterol

    3-Hexanoyl-NBD-cholesterol

    		 Fluorescent Dye Others
    3-C6-NBD-cholesterol is a fluorescent analog of Chol that can be used to measure the kinetics of membrane and intracellular trafficking .
    3-C6-NBD-cholesterol
  • HY-145728
    Alicaforsen

    ISIS-2302

    		 Integrin Inflammation/Immunology
    Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
    Alicaforsen
  • HY-145728A
    Alicaforsen sodium

    ISIS-2302 sodium

    		 Integrin Inflammation/Immunology
    Alicaforsen sodium is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
    Alicaforsen sodium
  • HY-123266
    D011-2120

    		Others Infection
    D011-2120 functions as an antiviral agent by inhibiting microtubule polymerization, disrupting the Golgi complex, and preventing viral trafficking to the plasma membrane during the virus egress process.
    D011-2120
  • HY-122246
    ML192

    		GPR55 PKC ERK Arrestin Metabolic Disease
    ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation .
    ML192
  • HY-P10282
    Synapsin I-(3-13)

    		CaMK Neurological Disease
    Synapsin I-(3-13), a substrate for CaMK1, is a glycoprotein. Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals .
    Synapsin I-(3-13)
  • HY-109187A
    Posenacaftor sodium
    1 Publications Verification

    PTI-801 sodium

    		 CFTR Inflammation/Immunology
    Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .
    Posenacaftor sodium
  • HY-109187
    Posenacaftor

    PTI-801

    		 CFTR Inflammation/Immunology
    Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .
    Posenacaftor
  • HY-123601
    DHQZ 36

    		Parasite Infection
    DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity .
    DHQZ 36
  • HY-131482
    PtdIns-(3)-P1(1,2-dioctanoyl) sodium

    		Liposome Others
    PtdIns-(3)-P1(1,2-dioctanoyl) sodium (compound 1b) is a glycogen phosphate that plays a key role in eukaryotic membrane trafficking and agonist-activated intracellular signaling .
    PtdIns-(3)-P1(1,2-dioctanoyl) sodium
  • HY-111772
    Elexacaftor
    30+ Cited Publications

    VX-445

    		 CFTR Autophagy Inflammation/Immunology
    Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
    Elexacaftor
  • HY-109187B
    (R)-Posenacaftor sodium

    (R)-PTI-801 sodium

    		 CFTR Inflammation/Immunology
    (R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of?CFTR?protein. Posenacaftor is used for the research of cystic fibrosis (CF) .
    (R)-Posenacaftor sodium
  • HY-145728B
    (R/S)-Alicaforsen

    (R/S)-ISIS-2302

    		 Integrin Inflammation/Immunology
    (R/S)-Alicaforsen is the racemate of Alicaforsen composed of R and S configurations. Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
    (R/S)-Alicaforsen
  • HY-P10085
    PKC-ε translocation inhibitor peptide

    		PKC Inflammation/Immunology
    PKC-ε translocation inhibitor peptide is a PKC-ε translocation inhibitor. PKC-ε translocation inhibitor peptide can regulate the rate of FcγR-mediated internalization of opsonized beads, has no effect of FcαR trafficking .
    PKC-ε translocation inhibitor peptide
  • HY-169325
    (S)-ACE-OH

    		Molecular Glues Cancer
    (S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98 .
    (S)-ACE-OH
  • HY-136151
    UNC10217938A
    1 Publications Verification

    		 Others Others
    UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides .
    UNC10217938A
  • HY-122228
    Cestrin

    		Others Others
    Cestrin is a cellulose Synthase 1 (CESA1) inhibitor. Cestrin inhibits cell elongation and reduces cellulose content and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1 .
    Cestrin
  • HY-124658
    G0507

    		Bacterial Infection
    G0507, a pyrrolopyrimidinedione compound, is a potent LolCDE ABC Transporter inhibitor. G0507 is a inhibitor of Escherichia coli growth and induces the extracytoplasmic σE stress response. G0507 acts as a chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria .
    G0507
  • HY-D1321A
    Cy 5 amine TFA

    Cyanine5 amine TFA

    		 Fluorescent Dye Others
    Cy 5 amine (Cyanine5 amine) TFA is a fluorescent dye. Cy 5 amine TFA can be used in the preparation of Cy5.5-labeled compound or polymers, which can be used for imaging cellular process and trafficking .
    Cy 5 amine TFA
  • HY-169233
    MED6-189

    		Parasite Infection
    MED6-189, a kalihinol analog, disrupts apicoplast function and vesicular trafficking in P. falciparum malaria (IC50 < 50 nM). MED6-189 targets the apicoplast, a nonphotosynthetic plastid found in most Apicomplexa parasites that is crucial for the synthesis of isoprenoids .
    MED6-189
  • HY-P2936
    Sphingomyelin phosphodiesterase, Streptomyces sp.

    		Phospholipase Metabolic Disease
    Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .
    Sphingomyelin phosphodiesterase, Streptomyces sp.
  • HY-E70278
    (9Z-Octadecenyl)-CoA triammonium

    		Biochemical Assay Reagents Metabolic Disease
    (9Z-Octadecenyl)-CoA triammonium is a coenzyme. (9Z-Octadecenyl)-CoA triammonium is a long-chain acyl-CoA esters. Long-chain acyl-CoA esters are involved in regulation of fatty acid synthesis, enzyme systems, vesicle trafficking, ion channels and ion pumps .
    (9Z-Octadecenyl)-CoA triammonium
  • HY-19970
    KM11060
    2 Publications Verification

    		 CFTR Autophagy Endocrinology
    KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research .
    KM11060
  • HY-12762
    QS11
    1 Publications Verification

    		 β-catenin Cancer
    QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .
    QS11
  • HY-158467
    Core 1 O-glycan (C1), 2AB labelled

    		Biochemical Assay Reagents Others
    Core 1 O-glycan (C1), 2AB labeled is a 2AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .
    Core 1 O-glycan (C1), 2AB labelled
  • HY-158471
    Core 1 O-glycan (C1)

    		Biochemical Assay Reagents Others
    Core 1 O-glycan (C1) is an important O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers .
    Core 1 O-glycan (C1)
  • HY-120821
    Endosidin-2
    1 Publications Verification

    ES2

    		 Others Others
    Endosidin2 (ES2) binds to the exocyst component of 70 kDa (EXO70) subunit of the exocyst complex with a Kd of 253 μM. Endosidin2 inhibits exocytosis and endosomal recycling in both plant and human cells and enhances plant vacuolar trafficking. Endosidin2 is a valuable new tool for the study of exocytosis .
    Endosidin-2
  • HY-112483
    QX77
    3 Publications Verification

    		 Autophagy Cancer
    QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells . QX77 can impede self-renewal and promote differentiation of ES cells .
    QX77
  • HY-163329
    BCH-HSP-C01

    		Others Neurological Disease
    BCH-HSP-C01 is a lead compound that restores AP-4-dependent protein trafficking in neuronal models of adapter protein complex 4 (AP-4)-associated hereditary spastic paraplegia. BCH-HSP-C01 can be used for the research of autophagy-associated diseases .
    BCH-HSP-C01
  • HY-14951
    Firategrast
    5+ Cited Publications

    SB 683699

    		 Integrin Neurological Disease
    Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity .
    Firategrast
  • HY-P3340
    Leptin (116-130)

    		iGluR Neurological Disease
    Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) .
    Leptin (116-130)
  • HY-130533
    ReAsH-EDT2

    		Fluorescent Dye Others
    ReAsH-EDT2 is a red fluorescent dye that marks proteins. ReAsH-EDT2 is a membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences which allows the protein to be imaged. ReAsH-EDT2 can be used for protein localization and trafficking. (λex=530 nm, λem=592 nm) .
    ReAsH-EDT2
  • HY-16592
    Brefeldin A
    Maximum Cited Publications
    82 Publications Verification

    BFA; Cyanein; Decumbin

    		 Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial Infection Cancer
    Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a CRISPR/Cas9 activator . Brefeldin A inhibits HSV-1 and has anti-cancer activity .
    Brefeldin A
  • HY-125836
    CCR4 antagonist 2

    		CCR Endocrinology Cancer
    CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca 2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively .
    CCR4 antagonist 2
  • HY-137975
    Exo2

    		Bacterial Endocrinology
    Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells .
    Exo2
  • HY-P99956
    Zilovertamab vedotin

    VLS-101; MK-2140

    		 Antibody-Drug Conjugates (ADCs) Apoptosis Cancer
    Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer .
    Zilovertamab vedotin
  • HY-134884
    INCB086550

    PD-1/PD-L1-IN-8

    		 PD-1/PD-L1 Cancer
    INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research .
    INCB086550
  • HY-145603
    Vanzacaftor

    VX-121

    		 CFTR Chloride Channel Neurological Disease
    Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .
    Vanzacaftor
  • HY-120475
    PBT434

    ATH434

    		 α-synuclein Neurological Disease
    PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .
    PBT434

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