Search Result
Results for "
venom peptide
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P5652
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Bacterial
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Infection
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Bombolitin II is an antimicrobial peptide derived from bumblebee venom. Bombolitin II can lysate erythrocyte and liposome .
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- HY-P5653
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Bacterial
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Infection
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Bombolitin III is an antimicrobial peptide derived from bumblebee venom. Bombolitin III can lysate erythrocyte and liposome .
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- HY-P5654
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Bacterial
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Infection
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Bombolitin IV is an antimicrobial peptide derived from bumblebee venom. Bombolitin IV can lysate erythrocyte and liposome .
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- HY-P1426
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Potassium Channel
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Inflammation/Immunology
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AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of Kv4 channel. AmmTX3 inhibits the A-type K + current (Ki: 131 nM) .
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- HY-P1426A
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Potassium Channel
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Inflammation/Immunology
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AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of Kv4 channel. AmmTX3 TFA inhibits the A-type K + current (Ki: 131 nM) .
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- HY-P5629
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Bacterial
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Infection
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MCF is an antimicrobial peptide derived from bee venom. MCF has activity against E.coli W 160-37, S.aureus 8530 and B.subtilis, the MIC values are 35-45 μg/ml, 25-35 μg/ml and 15-25 μg/ml .
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- HY-P5854
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Potassium Channel
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Neurological Disease
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Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .
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- HY-P5853
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Potassium Channel
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Inflammation/Immunology
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Aam-KTX is a Kv channel inhibitor with IC50 values of 1.1 nM and >750 nM for Kv1.3 and Kv1.1, respectively. Aam-KTX is a toxic peptide obtained from the venom of the scorpion Mesobuthus eupeus. Aam-KTX has potential in autoimmune diseases research .
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- HY-P5154
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Potassium Channel
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Neurological Disease
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Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .
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- HY-P10596
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Bacterial
Fungal
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Infection
Cancer
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Lasioglossin-III is an antimicrobial peptide that can be isolated from the venom of wild bees. Lasioglossin-III has high antibacterial activity against Gram-positive and Gram-negative bacteria, antifungal activity and antitumor activity. Lasioglossin-III has certain cytotoxicity against three cancer cell lines (HeLa S3, CRC SW 480 and CCRF-CEM T) with IC50 values of 4, 18 and 5 μM, respectively .
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- HY-W012479
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- HY-P0173A
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Chloride Channel
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Cancer
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Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
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- HY-P4071
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Cathelicidin-OH antimicrobial peptide
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Bacterial
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Infection
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OH-CATH is a natural antimicrobial peptide that can be isolated from the venom and tissue of Ophiophagus hannah (King Cobra) .
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- HY-P2785
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- HY-P5863
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Mamb-2
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Sodium Channel
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Neurological Disease
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Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases .
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- HY-P0173B
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Chloride Channel
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Cancer
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Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .
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- HY-P3111
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Potassium Channel
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Others
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Slotoxin, a peptide from Centruroides noxius Hoffmann scorpion venom, blocks high conductance calcium-activated potassium channel, with Kd of 1.5 nM[1].
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- HY-P1807
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Histamine Receptor
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Inflammation/Immunology
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Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .
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- HY-P2785A
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- HY-P5020
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Bacterial
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Infection
Cancer
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Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer .
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- HY-P3914
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Oct-CA(1-7)M(2-9)
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Bacterial
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Infection
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Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .
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- HY-W012479R
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Endogenous Metabolite
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Metabolic Disease
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H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.
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- HY-W012479S
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- HY-P5140
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Calcium Channel
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Metabolic Disease
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ω-Tbo-IT1 is a peptide toxin that can be isolated from the venom of Tibellus oblongus.ω-Tbo-IT1 is an inhibitor of insect calcium channel .
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- HY-P5183
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Sodium Channel
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Neurological Disease
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Hm1a is a disulfide-rich spider-venom peptide, and a NaV1.1 activator. Hm1a restores the function of inhibitory interneurons in Dravet syndrome (DS) mouse model .
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- HY-12537
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- HY-P3985
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Bradykinin potentiating peptide B
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Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
Others
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Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .
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- HY-P2702
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Adenylate Cyclase
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Others
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Helodormin is a VIP-secretin-like peptide isolated from the venom of the Mexican monster lizard (Heloderma suspectum). Helodormin affects a variety of cellular functions by modulating intracellular signaling through activation of adenylate cyclase. Helodormin can be used to study the evolution and function of the secretin and VIP peptide families .
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- HY-P5153
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μ-TRTX-Tp1a
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Sodium Channel
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Neurological Disease
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ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
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- HY-P0256
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Apamin
4 Publications Verification
Apamine
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Potassium Channel
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Neurological Disease
Inflammation/Immunology
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Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
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- HY-P3037
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Calcium Channel
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Neurological Disease
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Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca 2+-release channels/ryanodine receptors (RyRs) enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
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- HY-P0256A
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Apamine TFA
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Potassium Channel
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Neurological Disease
Inflammation/Immunology
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Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
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- HY-P3064
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Leiurotoxin I
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Potassium Channel
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Neurological Disease
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Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .
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- HY-P5783
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Sodium Channel
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Neurological Disease
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δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research .
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- HY-P5784
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Sodium Channel
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Neurological Disease
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δ-Buthitoxin-Hj1a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 17nM. δ-Buthitoxin-Hj1a can be used for the Dravet syndrome (DS) research .
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- HY-P10518
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Bacterial
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Infection
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Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .
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- HY-P2705
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Endogenous Metabolite
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Others
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Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .
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- HY-P10547
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MAC-1 peptide
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Bacterial
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Infection
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Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. Macropin has antibacterial activity against both Gram-positive and Gram-negative bacteria, and also exhibits inhibitory activity against fungi and moderate hemolytic activity against human erythrocytes. Macropin can be used in research on anti-infective therapy .
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- HY-P5865
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Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a
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Sodium Channel
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Neurological Disease
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Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects .
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- HY-P5788
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Potassium Channel
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Neurological Disease
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Hemitoxin, a scorpion-venom peptide, is a K + channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13 nM, 16 nM and 2 nM, respectively .
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- HY-P3037A
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Calcium Channel
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Neurological Disease
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Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca 2+-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
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- HY-P10572
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- HY-P5931
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Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13
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Potassium Channel
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Inflammation/Immunology
Cancer
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Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers .
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- HY-P5807A
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β-Mammal toxin Cn2 TFA
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Sodium Channel
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Neurological Disease
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Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .
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- HY-P1105
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Chloride Channel
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Neurological Disease
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GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types .
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- HY-P5154A
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Potassium Channel
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Neurological Disease
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Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .
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- HY-P5781
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Sodium Channel
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Neurological Disease
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δ-Theraphotoxin-Hm1b is a 42-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. δ-Theraphotoxin-Hm1b selectively inhibits inactivation of NaV1.1 but have no effect on NaV1.7 .
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- HY-P5780
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Sodium Channel
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Neurological Disease
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π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM .
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- HY-P10511
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Apoptosis
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Infection
Cancer
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Pantinin-3 is an antimicrobial peptide with antitumor activity found in the venom of the emperor scorpion (Pandinus imperator). Pantinin-3 shows selective toxicity against breast cancer cells (MDA-MB-231) and prostate cancer cells (DU-145). Pantinin-3 can induce apoptosis in tumor cells. Pantinin-3 can be used in cancer research .
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- HY-P10508
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Bacterial
Apoptosis
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Infection
Cancer
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Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce apoptosis in tumor cells .
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- HY-P1410
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GsMTx4
Maximum Cited Publications
45 Publications Verification
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TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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- HY-P10513
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AP1-Z1
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Bacterial
Fungal
Apoptosis
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Infection
Cancer
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AcrAP1 (AP1-Z1) is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP1 has antimicrobial activity and can inhibit the growth of Gram-positive and Gram-negative bacteria as well as yeast. AcrAP1 exerts antitumor activity by promoting apoptosis of cancer cells and inhibiting angiogenesis. AcrAP1 can be used in cancer therapy research .
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- HY-P1410A
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GsMTx4 TFA
Maximum Cited Publications
45 Publications Verification
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TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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- HY-P10515
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Bacterial
Fungal
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Infection
Cancer
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AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .
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- HY-P1280
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Potassium Channel
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Neurological Disease
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Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .
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- HY-P1280A
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Potassium Channel
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Neurological Disease
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Margatoxin TFA, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin TFA inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin TFA, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .
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- HY-P2707
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α-DTX
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Sodium Channel
Potassium Channel
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Others
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α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research .
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- HY-P5164
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Sodium Channel
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Neurological Disease
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GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively .GrTx1 can be used for neurological disease research .
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- HY-P5158
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Adrenergic Receptor
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Others
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Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5650
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Peptides
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Infection
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Bombolitin I is an antimicrobial peptide derived from bumblebee venom. Bombolitin I can lysate erythrocyte and liposome .
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- HY-P5652
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Bacterial
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Infection
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Bombolitin II is an antimicrobial peptide derived from bumblebee venom. Bombolitin II can lysate erythrocyte and liposome .
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- HY-P5653
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Bacterial
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Infection
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Bombolitin III is an antimicrobial peptide derived from bumblebee venom. Bombolitin III can lysate erythrocyte and liposome .
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- HY-P5654
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Bacterial
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Infection
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Bombolitin IV is an antimicrobial peptide derived from bumblebee venom. Bombolitin IV can lysate erythrocyte and liposome .
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- HY-P5166
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Peptides
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Others
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Lys-Conopressin-G, a vasotocin-like peptide, can be isolated from the venom of the worm-hunting snail (conus imperialis) .
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- HY-P1426
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Potassium Channel
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Inflammation/Immunology
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AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of Kv4 channel. AmmTX3 inhibits the A-type K + current (Ki: 131 nM) .
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- HY-P5167
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Peptides
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Inflammation/Immunology
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GsAF-1 is a peptide toxin containing three disulfide bonds. GsAF-1 can be isolated from the venom of the Chilean pink tarantula. GsAF-1 can be used for research of moderate-to-severe pain .
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- HY-P1426A
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Potassium Channel
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Inflammation/Immunology
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AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of Kv4 channel. AmmTX3 TFA inhibits the A-type K + current (Ki: 131 nM) .
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- HY-P5629
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Bacterial
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Infection
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MCF is an antimicrobial peptide derived from bee venom. MCF has activity against E.coli W 160-37, S.aureus 8530 and B.subtilis, the MIC values are 35-45 μg/ml, 25-35 μg/ml and 15-25 μg/ml .
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- HY-P5722
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Peptides
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Infection
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Peptide 5f is an antimicrobial peptide derived from wasp venom. Peptide 5f has antimicrobial activity against bacteria and fungi. Peptide 5f has little hemolytic activity on human red blood cells .
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- HY-P5854
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Potassium Channel
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Neurological Disease
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Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .
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- HY-P5853
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Potassium Channel
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Inflammation/Immunology
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Aam-KTX is a Kv channel inhibitor with IC50 values of 1.1 nM and >750 nM for Kv1.3 and Kv1.1, respectively. Aam-KTX is a toxic peptide obtained from the venom of the scorpion Mesobuthus eupeus. Aam-KTX has potential in autoimmune diseases research .
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- HY-P5151
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Peptides
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Others
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LiTx3 is a lethal and cysteine-rich peptide. LiTx3 can be isolated from L. intermedia crude venom. LiTx3 induces flaccid paralysis in Spodoptera frugiperda larvae .
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- HY-P5154
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Potassium Channel
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Neurological Disease
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Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .
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- HY-P10596
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Bacterial
Fungal
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Infection
Cancer
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Lasioglossin-III is an antimicrobial peptide that can be isolated from the venom of wild bees. Lasioglossin-III has high antibacterial activity against Gram-positive and Gram-negative bacteria, antifungal activity and antitumor activity. Lasioglossin-III has certain cytotoxicity against three cancer cell lines (HeLa S3, CRC SW 480 and CCRF-CEM T) with IC50 values of 4, 18 and 5 μM, respectively .
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- HY-P5059
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- HY-P5717
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Peptides
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Infection
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Peptide 12d is an antimicrobial peptide isolated from the venom of wasp. Peptide 12d mediates antimicrobial response by stimulating mast cell degranulation .
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- HY-P1902
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Peptides
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Cardiovascular Disease
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Cardiotoxin Analog (CTX) IV (6-12) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .
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- HY-P1902A
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Peptides
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Others
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Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .
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- HY-P1543
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Peptides
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Neurological Disease
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Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.
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- HY-P0173A
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Chloride Channel
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Cancer
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Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.
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- HY-P4071
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Cathelicidin-OH antimicrobial peptide
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Bacterial
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Infection
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OH-CATH is a natural antimicrobial peptide that can be isolated from the venom and tissue of Ophiophagus hannah (King Cobra) .
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- HY-P2785
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- HY-P5863
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Mamb-2
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Sodium Channel
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Neurological Disease
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Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases .
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- HY-P0173B
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Chloride Channel
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Cancer
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Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .
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- HY-P3111
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Potassium Channel
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Others
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Slotoxin, a peptide from Centruroides noxius Hoffmann scorpion venom, blocks high conductance calcium-activated potassium channel, with Kd of 1.5 nM[1].
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- HY-P1807
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Histamine Receptor
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Inflammation/Immunology
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Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .
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- HY-P1987
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Peptides
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Neurological Disease
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Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .
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- HY-P2785A
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- HY-P5020
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Bacterial
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Infection
Cancer
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Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer .
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- HY-P3914
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Oct-CA(1-7)M(2-9)
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Bacterial
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Infection
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Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .
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- HY-P5140
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Calcium Channel
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Metabolic Disease
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ω-Tbo-IT1 is a peptide toxin that can be isolated from the venom of Tibellus oblongus.ω-Tbo-IT1 is an inhibitor of insect calcium channel .
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- HY-P5183
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Sodium Channel
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Neurological Disease
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Hm1a is a disulfide-rich spider-venom peptide, and a NaV1.1 activator. Hm1a restores the function of inhibitory interneurons in Dravet syndrome (DS) mouse model .
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- HY-12537
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- HY-P3985
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Bradykinin potentiating peptide B
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Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
Others
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Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .
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- HY-P2702
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Adenylate Cyclase
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Others
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Helodormin is a VIP-secretin-like peptide isolated from the venom of the Mexican monster lizard (Heloderma suspectum). Helodormin affects a variety of cellular functions by modulating intracellular signaling through activation of adenylate cyclase. Helodormin can be used to study the evolution and function of the secretin and VIP peptide families .
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- HY-P5153
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μ-TRTX-Tp1a
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Sodium Channel
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Neurological Disease
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ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
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- HY-P0256
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Apamin
4 Publications Verification
Apamine
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Potassium Channel
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Neurological Disease
Inflammation/Immunology
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Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
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- HY-P3037
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Calcium Channel
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Neurological Disease
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Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca 2+-release channels/ryanodine receptors (RyRs) enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
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- HY-P0256A
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Apamine TFA
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Potassium Channel
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Neurological Disease
Inflammation/Immunology
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Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
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- HY-P3064
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Leiurotoxin I
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Potassium Channel
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Neurological Disease
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Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .
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- HY-P3050
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Peptides
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Cardiovascular Disease
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Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .
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- HY-P3053
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Peptides
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Cardiovascular Disease
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Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .
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- HY-P5783
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Sodium Channel
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Neurological Disease
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δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research .
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- HY-P5784
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Sodium Channel
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Neurological Disease
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δ-Buthitoxin-Hj1a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 17nM. δ-Buthitoxin-Hj1a can be used for the Dravet syndrome (DS) research .
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- HY-P10518
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Bacterial
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Infection
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Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .
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- HY-P2705
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Endogenous Metabolite
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Others
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Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .
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- HY-P10547
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MAC-1 peptide
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Bacterial
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Infection
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Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. Macropin has antibacterial activity against both Gram-positive and Gram-negative bacteria, and also exhibits inhibitory activity against fungi and moderate hemolytic activity against human erythrocytes. Macropin can be used in research on anti-infective therapy .
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- HY-P5865
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Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a
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Sodium Channel
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Neurological Disease
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Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects .
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- HY-P5788
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Potassium Channel
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Neurological Disease
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Hemitoxin, a scorpion-venom peptide, is a K + channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13 nM, 16 nM and 2 nM, respectively .
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- HY-P3037A
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Calcium Channel
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Neurological Disease
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Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca 2+-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca 2+ from the sarcoplasmatic reticulum into the cell .
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- HY-P10572
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- HY-P5931
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Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13
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Potassium Channel
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Inflammation/Immunology
Cancer
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Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers .
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- HY-P5807A
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β-Mammal toxin Cn2 TFA
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Sodium Channel
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Neurological Disease
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Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .
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- HY-P1105
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Chloride Channel
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Neurological Disease
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GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types .
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- HY-P5154A
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Potassium Channel
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Neurological Disease
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Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .
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- HY-P5781
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Sodium Channel
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Neurological Disease
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δ-Theraphotoxin-Hm1b is a 42-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. δ-Theraphotoxin-Hm1b selectively inhibits inactivation of NaV1.1 but have no effect on NaV1.7 .
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- HY-P0099
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Peptides
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Others
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Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .
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- HY-P5780
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Sodium Channel
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Neurological Disease
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π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM .
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- HY-P10511
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Apoptosis
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Infection
Cancer
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Pantinin-3 is an antimicrobial peptide with antitumor activity found in the venom of the emperor scorpion (Pandinus imperator). Pantinin-3 shows selective toxicity against breast cancer cells (MDA-MB-231) and prostate cancer cells (DU-145). Pantinin-3 can induce apoptosis in tumor cells. Pantinin-3 can be used in cancer research .
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- HY-P10508
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Bacterial
Apoptosis
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Infection
Cancer
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Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce apoptosis in tumor cells .
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- HY-P1410
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GsMTx4
Maximum Cited Publications
45 Publications Verification
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TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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- HY-P10513
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AP1-Z1
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Bacterial
Fungal
Apoptosis
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Infection
Cancer
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AcrAP1 (AP1-Z1) is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP1 has antimicrobial activity and can inhibit the growth of Gram-positive and Gram-negative bacteria as well as yeast. AcrAP1 exerts antitumor activity by promoting apoptosis of cancer cells and inhibiting angiogenesis. AcrAP1 can be used in cancer therapy research .
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- HY-P1410A
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GsMTx4 TFA
Maximum Cited Publications
45 Publications Verification
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TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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- HY-P10515
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Bacterial
Fungal
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Infection
Cancer
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AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .
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- HY-P1280
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Potassium Channel
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Neurological Disease
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Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .
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- HY-P1280A
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Potassium Channel
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Neurological Disease
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Margatoxin TFA, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin TFA inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin TFA, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .
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- HY-P2707
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α-DTX
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Sodium Channel
Potassium Channel
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Others
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α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research .
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- HY-P5164
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Sodium Channel
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Neurological Disease
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GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively .GrTx1 can be used for neurological disease research .
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- HY-P5158
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Adrenergic Receptor
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Others
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Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-W012479S
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H-D-Trp-OH-d5 (D-Tryptophan-d5) is the deuterium labeled H-D-Trp-OH. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.
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