Trivalent hydroxyarsinothricn (Synonyms: R-AST-OH)

Cat. No.: HY-158378: FAQs
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Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy.

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Trivalent hydroxyarsinothricn Chemical Structure

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Description	Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy^[1].
Molecular Weight	211.05
Formula	C₄H₁₀AsNO₄
SMILES	O=C(O)[C@H](N)CC[As](O)O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Sarkarai Nadar V, et al. Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate. Organometallics. 2024 May 8;43(10):1137-1142. [Content Brief]

Trivalent hydroxyarsinothricn Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trivalent hydroxyarsinothricnR-AST-OHGlutaminasebreast cancerTNBCMDA-MB-231KGAInhibitorinhibitorinhibit

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Trivalent hydroxyarsinothricn (Synonyms: R-AST-OH)

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