2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. Trivalent hydroxyarsinothricn

Trivalent hydroxyarsinothricn  (Synonyms: R-AST-OH)

Cat. No.: HY-158378
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Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy.

For research use only. We do not sell to patients.

Trivalent hydroxyarsinothricn Chemical Structure

Trivalent hydroxyarsinothricn Chemical Structure

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Trivalent hydroxyarsinothricn Related Antibodies

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Description

Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy[1].

Molecular Weight

211.05

Formula

C4H10AsNO4
SMILES

O=C(O)[C@H](N)CC[As](O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Trivalent hydroxyarsinothricn Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trivalent hydroxyarsinothricnR-AST-OHGlutaminasebreast cancerTNBCMDA-MB-231KGAInhibitorinhibitorinhibit

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