2. Immunology/Inflammation Anti-infection
  3. COX Parasite
  4. Withangulatin A

Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function.

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Withangulatin A Chemical Structure

Withangulatin A Chemical Structure

CAS No. : 120824-03-5

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Based on 1 publication(s) in Google Scholar

Withangulatin A Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
2.37 μM
Compound: 1; WA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HepG2 IC50
2.85 μM
Compound: 1; WA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HK-2 IC50
6.41 μM
Compound: 1; WA
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HT-29 IC50
2.48 μM
Compound: 1; WA
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
L02 IC50
8.21 μM
Compound: 1; WA
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
MCF7 IC50
6.32 μM
Compound: 1; WA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
Molecular Weight

526.62

Formula

C30H38O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([C@H](C=CC2=O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@]4([C@H](C=C5[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)C)C)OC(C)=O)O)C)([H])O3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 3 mg/mL (5.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8989 mL 9.4945 mL 18.9890 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.76%

SDS (251 KB)

COA (264 KB) HNMR (211 KB) LCMS (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8989 mL 9.4945 mL 18.9890 mL 47.4726 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL 9.4945 mL
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Withangulatin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Withangulatin A120824-03-5COXParasiteCyclooxygenasecyclooxygenase-2 (COX-2)isolatePhysalis angulata Lanti-tumortrypanocidal activityanti-inflammatoryInhibitorinhibitorinhibit

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