2. Anti-infection Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt
  3. Bacterial PPAR c-Myc NO Synthase Caspase ERK
  4. Fucoxanthin

Fucoxanthin  (Synonyms: all-trans-Fucoxanthin)

Cat. No.: HY-N2302 Purity: 99.47%
COA Handling Instructions

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Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.

For research use only. We do not sell to patients.

Fucoxanthin Chemical Structure

Fucoxanthin Chemical Structure

CAS No. : 3351-86-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 122 In-stock
Solution
10 mM * 1 mL in DMSO USD 122 In-stock
Solid
5 mg USD 84 In-stock
10 mg USD 135 In-stock
25 mg USD 312 In-stock
50 mg USD 550 In-stock
100 mg USD 880 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Fucoxanthin:

Fucoxanthin Related Antibodies

Top Publications Citing Use of Products

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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nNOS iNOS eNOS

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

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Description

Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities[1][2][3][4][5][6][7][8][9].

IC50 & Target

PPARγ

 

UCP1

 

PPARα

 

iNOS

 

Caspase 3

 

Caspase-8

 

Caspase 9

 

SOD

 

ERK2

 

In Vitro

Fucoxanthin (2.8-6.2 µM, 24 h) shows obvious bacteriostatic effect on all tested Mtb strains, with MIC values of 2.8-4.1 µM[4].
Fucoxanthin (0-25 µM, 24 h) inhibits the proliferation of HeLa and SiHa cervical cancer cell lines and promotes cell stasis in the G0/G1 cell cycle phase[5].
Fucoxanthin (10 µM, 12 h) inhibits the cell viability of HTLV-1-infected T cell lines by inducing G1 cell cycle arrest and apoptosis, thereby exhibiting anticancer activity[7].
Fucoxanthin (0-100 µg/mL, 24 h) dose-dependent inhibits the expression of TNF-α, PGE2, iNOS and COX-2 proteins in RAW 264.7 cells[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fucoxanthin Related Antibodies

Western Blot Analysis[8]

Cell Line: RAW 264.7 cells
Concentration: 0-100 µg/mL,
Incubation Time: 24 h
Result: Inhibited LPS-induced iNOS and COX-2 protein expression in RAW 264.7 cells.
Decreased NO and PEG2 concentrations in LPS-induced RAW 264.7 cells.

RT-PCR[6]

Cell Line: Hela and SiHa cells
Concentration: 10 µg/mL
Incubation Time: 4 h
Result: Down-regulated N-myc mRNA expression.
In Vivo

Fucoxanthin (10-2000 mg/kg, p.o.) does not cause death or abnormal appearance in ICR mice and rats[3].
Fucoxanthin (10-50 mg/kg/day, p.o.) can protect the cadmium-induced renal injury mouse model by improving the antioxidant capacity of mice[9].
Fucoxanthin (0.1-10 mg/kg, i.v.) shows a dose-dependent anti-ocular inflammatory effect on EIU (endotoxin-induced uveitis) [8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male and female Crl:CD (SD) rats, 6-week-old male and female ICR mice[3]
Dosage: 10-2000 mg/kg/day for 28/30 days
Administration: p.o.
Result: No abnormal appearance or death occurred in the rats and ICR mice.
Significantly increased the concentration of serum total cholesterol in rats and ICR mice.
Animal Model: mice models subjected to cadmium-induced kidney damage, Six- to eight-week-old male Kunming mice (weight, 22–26 gram (g)/per mouse)[9]
Dosage: 10-50 mg/kg/day for 14 days
Administration: p.o.
Result: Blocked the Cd-induced increase in the cadmium level.
Significantly decreased the levels of blood urea nitrogen, creatinine and lipid peroxidation, and increased the levels of SOD, POD and reduced glutathione.
Helped to restore mitochondrial structure and inhibit renal cell apoptosis.
Clinical Trial
Molecular Weight

658.91

Formula

C42H58O6
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=C(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C([H])=[C@@]=C([C@@]1(O)C)C(C)(C[C@H](OC(C)=O)C1)C)C[C@]2(C3(C)C)[C@@](C)(C[C@@H](O)C3)O2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (18.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5177 mL 7.5883 mL 15.1766 mL
5 mM 0.3035 mL 1.5177 mL 3.0353 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 1.25 mg/mL (1.90 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.47%

COA (242 KB) HNMR (311 KB) RP-HPLC (264 KB) MS (72 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5177 mL 7.5883 mL 15.1766 mL 37.9415 mL
5 mM 0.3035 mL 1.5177 mL 3.0353 mL 7.5883 mL
10 mM 0.1518 mL 0.7588 mL 1.5177 mL 3.7941 mL
15 mM 0.1012 mL 0.5059 mL 1.0118 mL 2.5294 mL
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Fucoxanthin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fucoxanthin3351-86-8all-trans-FucoxanthinBacterialPPARc-MycNO SynthaseCaspaseERKPeroxisome proliferator-activated receptorsMycNitric oxide synthasesNOSExtracellular signal regulated kinasesadipocyteantioxidantantiobesitydietary supplementsanticancerapoptosiscell cycleproliferationangiogenesisInhibitorinhibitorinhibit

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