2. Anti-infection Autophagy NF-κB Immunology/Inflammation Apoptosis
  3. Parasite Autophagy NF-κB Interleukin Related NO Synthase MDM-2/p53 TNF Receptor RANKL/RANK Caspase
  4. 10-Hydroxydecanoic acid

10-Hydroxydecanoic acid  (Synonyms: NSC 15139; 10-HDAA)

Cat. No.: HY-Y0148 Purity: 98.77%
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10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells.

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10-Hydroxydecanoic acid Chemical Structure

10-Hydroxydecanoic acid Chemical Structure

CAS No. : 1679-53-4

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Based on 1 publication(s) in Google Scholar

10-Hydroxydecanoic acid Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].

In Vitro

10-Hydroxydecanoic acid (0-10 mM; 30 min) inhibits LPS (HY-D1056)-induced NO production in RAW264 cells in a concentration-dependent manner within the range of 0.5-5 mM[1].
10-Hydroxydecanoic acid (5 mM; 30 min) inhibits the increase of IRF-1 protein induced by LPS (HY-D1056) in RAW264 cells[1].
10-Hydroxydecanoic acid (100 μM and 1 mM; 6 h) increases the expression level of RANK on the surface of caco2 cell monolayers[2].
10-Hydroxydecanoic acid has a significant insecticidal effect on Aedes aegypti larvae (LC50=37.8 μg/mL)[3].
10-Hydroxydecanoic acid has a significant anti-malarial effect (IC50=2.65μg/mL)[3].
10-Hydroxydecanoic acid has a significant anti-Leishmania effect on intracellular amastigotes of Leishmania (IC50=3.77 μg/mL)[3].
10-Hydroxydecanoic acid (0-4 mM; 1 h) effectively reduces the level of iNOS in BV-2 microglia induced by LPS (HY-D1056) and activates cell autophagy[4].
10-Hydroxydecanoic acid (0-4 mM; 1 h) has no inhibitory effect on the increase of cyclooxygenase-2 (COX-2), iNOS and TNF-α induced by LPS in BV-2 microglia cells transfected with specific p53 siRNA[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10-Hydroxydecanoic acid Related Antibodies

RT-PCR[1]

Cell Line: LPS-induced RAW264 cells
Concentration: 0-10 mM
Incubation Time: 30 min
Result: Inhibited the expression of iNOS mRNA.
Did not inhibit the increase of total IRF-1 mRNA level in cells after LPS stimulation, but reduced the IRF-1 mRNA level in polysomes at a dose of 5 mM.

Western Blot Analysis[1]

Cell Line: LPS-induced RAW264 cells
Concentration: 0-10 mM
Incubation Time: 30 min
Result: Inhibited LPS-induced phosphorylation of Akt and eukaryotic initiation factor 4E-BP1.

Western Blot Analysis[4]

Cell Line: LPS-induced BV-2 cells
Concentration: 1, 2 and 4 mM
Incubation Time: 1 h
Result: Inhibited the increase of IL-6, TNF, MCP-1, NLRP3, cleaved caspase-1 and IL-1β and reduced the level of p-p53 in a concentration-dependent manner.
In Vivo

10-Hydroxydecanoic acid (1 mol/L; Intranasal injection 100 μL; once daily for 3 days) increases the number of microfold cells (M cells) in the epithelium lining the luminal surface of the nasopharyngeal-associated lymphoid tissue (NALT) in cynomolgus monkeys[2].
10-Hydroxydecanoic acid (2.4 mg; p.o.; enteric-coated capsules taken orally once a day for 20 days) increases the number of M cells and improves the level of antigen-specific immunoglobulin A (IgA) in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) in cynomolgus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: cynomolgus macaque [2]
Dosage: 1 mol/L, Administer 100 μL
Administration: Intranasal administration; once a day for 3 days
Result: Increased number of gp2-positive cells in the epithelium overlying NALT follicles.
Animal Model: cynomolgus macaque [2]
Dosage: 2.4 mg
Administration: p.o.; enteric-coated capsules once a day for 20 days
Result: Increased the number of gp2-positive M cells.
10-HDAA (2.4 mg) enteric-coated capsules containing poliovirus antigen (106 TCID50) induced poliovirus- and influenza virus-specific IgAs on day 12 after oral administration.
Molecular Weight

188.26

Formula

C10H20O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCCCO
Structure Classification
Initial Source

major fatty acids in royal jelly
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (265.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3118 mL 26.5590 mL 53.1180 mL
5 mM 1.0624 mL 5.3118 mL 10.6236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

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C2

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V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (6.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (6.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.77%

SDS (393 KB)

COA (239 KB) HNMR (129 KB) RP-HPLC (136 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3118 mL 26.5590 mL 53.1180 mL 132.7951 mL
5 mM 1.0624 mL 5.3118 mL 10.6236 mL 26.5590 mL
10 mM 0.5312 mL 2.6559 mL 5.3118 mL 13.2795 mL
15 mM 0.3541 mL 1.7706 mL 3.5412 mL 8.8530 mL
20 mM 0.2656 mL 1.3280 mL 2.6559 mL 6.6398 mL
25 mM 0.2125 mL 1.0624 mL 2.1247 mL 5.3118 mL
30 mM 0.1771 mL 0.8853 mL 1.7706 mL 4.4265 mL
40 mM 0.1328 mL 0.6640 mL 1.3280 mL 3.3199 mL
50 mM 0.1062 mL 0.5312 mL 1.0624 mL 2.6559 mL
60 mM 0.0885 mL 0.4427 mL 0.8853 mL 2.2133 mL
80 mM 0.0664 mL 0.3320 mL 0.6640 mL 1.6599 mL
100 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3280 mL
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10-Hydroxydecanoic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Hydroxydecanoic acid1679-53-4NSC 15139 10-HDAANSC15139NSC-15139ParasiteAutophagyNF-κBInterleukin RelatedNO SynthaseMDM-2/p53TNF ReceptorRANKL/RANKCaspaseNuclear factor-κBNuclear factor-kappaBILNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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