2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. NEKs

NEKs

NIMA–related Kinases; NIMA (never in mitosis gene a)-related Expressed Kinases

NIMA-related Kinases (NEKs) are a class of serine/threonine protein kinases ubiquitous in eukaryotic organisms. NEKs play pivotal roles in cell cycle regulation, including chromosome condensation, mitotic entry, centrosome duplication, and mitotic exit.
The NEK family comprises 11 members in humans (NEK1-NEK11). NEK family members are widely involved in key biological processes such as cell cycle regulation, ciliogenesis, and DNA damage repair, making them potential therapeutic targets for diseases.
Abnormal activation or mutations of NEKs are closely associated with cancers, genetic diseases, neurodegenerative diseases, and other conditions[1][2][3][4].

NEKs Isoform Specific Products:

NEKs Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101030
    MBM-17
    		Inhibitor
    MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice.
    MBM-17
  • HY-117398
    HCI-2184
    		Inhibitor
    HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity.
    HCI-2184
  • HY-120356
    T-1101
    		Inhibitor
    T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.
    T-1101
  • HY-173154
    NK7-902
    		Degrader
    NK7-902 is a CRBN molecular glue degrader of NEK7. NK7-902 fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 shows activity in murine systems.
    NK7-902
  • HY-150046
    Nek2-IN-6
    Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor.
    Nek2-IN-6
  • HY-169933
    NEK7-IN-1
    		Inhibitor
    NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC50 <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC50 <50 nM.
    NEK7-IN-1
  • HY-120330
    Nek2-IN-5
    Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior. Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Nek2-IN-5
NEKs Isoform Comparison

NEK1

NEK2

NEK6

NEK7

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

NEKs Degraders & Inhibitors
Product NameNEK1NEK2NEK6NEK7Purity    
BSc5367
NEK1, IC50: 11.5 nM
   98.65%
INH154 
NEK2
  99.89%
INH1 
NEK2
  99.85%
T-1101 tosylate 
NEK2
  99.05%
MBM-55 
NEK2, IC50: 1 nM
  99.94%
LC-04-045   
NEK7, DC50: 7 nM
ZINC05007751  
NEK6, IC50: 3.4 μM
 98.47%
JH295 
NEK2, IC50: 770 nM
  98.99%
CK7
NEK1
   99.72%
SLC3037   
NEK7
99.85%
INH6 
NEK2
  99.53%
NBI-961 
NEK2
  99.73%
TAI-1 
NEK2
  98.02%
MBM-17S 
NEK2, IC50: 3 nM
  
JH295 hydrate 
NEK2, IC50: 770 nM
  ≥99.0%
Nek2/Hec1-IN-2 
NEK2
  ≥98.0%
Nek2-IN-4 
NEK2, IC50: 15 nM
  
MBM-55S 
NEK2, IC50: 1 nM
  
MBM-17 
NEK2, IC50: 3 nM
  
T-1101 
NEK2
  
Nek2-IN-6 
NEK2
  
Nek2-IN-5 
NEK2