2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis Epigenetics
  3. Src ATM/ATR Apoptosis mTOR AMPK
  4. AD1058

AD1058 is an orally active, selective, and blood-brain barrier permeable inhibitor of ATR. AD1058 exhibits in vivo anticancer activity, inhibiting cell proliferation, disrupting the cell cycle, and inducing Apoptosis. AD1058 can be utilized in research on brain and central nervous system metastases stemming from advanced solid tumors.

For research use only. We do not sell to patients.

AD1058 Chemical Structure

AD1058 Chemical Structure

CAS No. : 2907782-78-7

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AD1058 Related Antibodies

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Lck Fyn Blk

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ATM ATR

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mTOR mTORC1 mTORC2

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

AD1058 is an orally active, selective, and blood-brain barrier permeable inhibitor of ATR. AD1058 exhibits in vivo anticancer activity, inhibiting cell proliferation, disrupting the cell cycle, and inducing Apoptosis. AD1058 can be utilized in research on brain and central nervous system metastases stemming from advanced solid tumors[1].

IC50 & Target

ATR

1.6 nM (IC50)

mTOR

45.83 nM (IC50)

ARK5

7314.00 nM (IC50)

LCK

2594.00 nM (IC50)

Molecular Weight

412.47

Formula

C19H20N6O3S
CAS No.
SMILES

O=S(N1C=CC2=C(N3[C@H](C)COCC3)N=C(C4=C5C(NC=C5)=NC=C4)N=C21)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AD1058 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD10582907782-78-7AD 1058AD-1058SrcATM/ATRApoptosismTORAMPKAtaxia telangiectasia mutatedATM and RAD3 relatedMammalian target of RapamycinAMP-activated protein kinaseblood-brain barrier (BBB)apoptosissolid tumorsA2780OCI-Ly10LoVoHCT116H446HT-29SU-DHL4DLD1Capan-1PC-3Inhibitorinhibitorinhibit

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