ADP-β-S trilithium (Synonyms: Adenosine 5'-β-thiodiphosphate (trilithium))

Cat. No.: HY-134353B Purity: 85.3%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome.

For research use only. We do not sell to patients.

ADP-β-S trilithium Chemical Structure

CAS No. : 73536-95-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

P2Y12 Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	IC₅₀	20 μM Compound: 5	Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis	[PMID: 26447940]

Molecular Weight

461.07

Formula

C₁₀H₁₂Li₃N₅O₉P₂S

CAS No.

73536-95-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(O[Li])(S[Li])=O)(O[Li])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (43.38 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1689 mL	10.8443 mL	21.6887 mL
5 mM	0.4338 mL	2.1689 mL	4.3377 mL
10 mM	0.2169 mL	1.0844 mL	2.1689 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 85.3%

Select Batch:

Data Sheet (275 KB) SDS (557 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al., Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020 Feb;50(2):205-219. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1689 mL	10.8443 mL	21.6887 mL	54.2217 mL
	5 mM	0.4338 mL	2.1689 mL	4.3377 mL	10.8443 mL
	10 mM	0.2169 mL	1.0844 mL	2.1689 mL	5.4222 mL
	15 mM	0.1446 mL	0.7230 mL	1.4459 mL	3.6148 mL
	20 mM	0.1084 mL	0.5422 mL	1.0844 mL	2.7111 mL
	25 mM	0.0868 mL	0.4338 mL	0.8675 mL	2.1689 mL
	30 mM	0.0723 mL	0.3615 mL	0.7230 mL	1.8074 mL
	40 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

ADP-β-S trilithium Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADP-β-S trilithium73536-95-5Adenosine 5'-β-thiodiphosphate trilithiumP2Y ReceptorNF-κBNuclear factor-κBNuclear factor-kappaBmicroglialMG6Inhibitorinhibitorinhibit

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