1. GPCR/G Protein NF-κB
  2. P2Y Receptor NF-κB
  3. ADP-β-S trilithium

ADP-β-S trilithium  (Synonyms: Adenosine 5'-β-thiodiphosphate (trilithium))

Cat. No.: HY-134353B Purity: 85.3%
SDS COA Handling Instructions

ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome.

For research use only. We do not sell to patients.

ADP-β-S trilithium Chemical Structure

ADP-β-S trilithium Chemical Structure

CAS No. : 73536-95-5

Size Price Stock Quantity
1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 650 In-stock
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Description

ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome[1].

IC50 & Target

P2Y12 Receptor

 

Cellular Effect
Cell Line Type Value Description References
PC-12 IC50
20 μM
Compound: 5
Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis
Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis
[PMID: 26447940]
Molecular Weight

461.07

Formula

C10H12Li3N5O9P2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(O[Li])(S[Li])=O)(O[Li])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (43.38 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1689 mL 10.8443 mL 21.6887 mL
5 mM 0.4338 mL 2.1689 mL 4.3377 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 85.3%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1689 mL 10.8443 mL 21.6887 mL 54.2217 mL
5 mM 0.4338 mL 2.1689 mL 4.3377 mL 10.8443 mL
10 mM 0.2169 mL 1.0844 mL 2.1689 mL 5.4222 mL
15 mM 0.1446 mL 0.7230 mL 1.4459 mL 3.6148 mL
20 mM 0.1084 mL 0.5422 mL 1.0844 mL 2.7111 mL
25 mM 0.0868 mL 0.4338 mL 0.8675 mL 2.1689 mL
30 mM 0.0723 mL 0.3615 mL 0.7230 mL 1.8074 mL
40 mM 0.0542 mL 0.2711 mL 0.5422 mL 1.3555 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ADP-β-S trilithium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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