2. Anti-infection Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
  4. Atazanavir

Atazanavir  (Synonyms: BMS-232632)

Cat. No.: HY-17367 Purity: 99.86%
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Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.

For research use only. We do not sell to patients.

Atazanavir Chemical Structure

Atazanavir Chemical Structure

CAS No. : 198904-31-3

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10 mg USD 70 In-stock
50 mg USD 150 In-stock
100 mg USD 230 In-stock
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Based on 11 publication(s) in Google Scholar

Other Forms of Atazanavir:

Atazanavir Related Antibodies

Top Publications Citing Use of Products

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HIV HIV-1 HIV-2

View All Cytochrome P450 Isoform Specific Products:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

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Description

Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

IC50 & Target

CYP3

 

HIV-1

 

Clinical Trial
Molecular Weight

704.86

Formula

C38H52N6O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (118.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4187 mL 7.0936 mL 14.1872 mL
5 mM 0.2837 mL 1.4187 mL 2.8374 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

COA (252 KB) HNMR (142 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4187 mL 7.0936 mL 14.1872 mL 35.4680 mL
5 mM 0.2837 mL 1.4187 mL 2.8374 mL 7.0936 mL
10 mM 0.1419 mL 0.7094 mL 1.4187 mL 3.5468 mL
15 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
20 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7734 mL
25 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL
30 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
40 mM 0.0355 mL 0.1773 mL 0.3547 mL 0.8867 mL
50 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7094 mL
60 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5911 mL
80 mM 0.0177 mL 0.0887 mL 0.1773 mL 0.4434 mL
100 mM 0.0142 mL 0.0709 mL 0.1419 mL 0.3547 mL
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Atazanavir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atazanavir198904-31-3BMS-232632BMS232632BMS 232632HIVHIV ProteaseSARS-CoVCytochrome P450P-glycoproteinEndogenous MetaboliteHuman immunodeficiency virusSARS coronavirusCYPsP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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