2. PROTAC
  3. PROTAC Linkers
  4. Cbz-NH-PEG1-CH2COOH

Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Cbz-NH-PEG1-CH2COOH Chemical Structure

Cbz-NH-PEG1-CH2COOH Chemical Structure

CAS No. : 1260092-43-0

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Cbz-NH-PEG1-CH2COOH Related Antibodies

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Description

Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cbz-NH-PEG1-CH2COOH Related Antibodies
Molecular Weight

253.25

Formula

C12H15NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COCCNC(OCC1=CC=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (394.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9487 mL 19.7433 mL 39.4867 mL
5 mM 0.7897 mL 3.9487 mL 7.8973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

COA (243 KB) HNMR (240 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9487 mL 19.7433 mL 39.4867 mL 98.7167 mL
5 mM 0.7897 mL 3.9487 mL 7.8973 mL 19.7433 mL
10 mM 0.3949 mL 1.9743 mL 3.9487 mL 9.8717 mL
15 mM 0.2632 mL 1.3162 mL 2.6324 mL 6.5811 mL
20 mM 0.1974 mL 0.9872 mL 1.9743 mL 4.9358 mL
25 mM 0.1579 mL 0.7897 mL 1.5795 mL 3.9487 mL
30 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2906 mL
40 mM 0.0987 mL 0.4936 mL 0.9872 mL 2.4679 mL
50 mM 0.0790 mL 0.3949 mL 0.7897 mL 1.9743 mL
60 mM 0.0658 mL 0.3291 mL 0.6581 mL 1.6453 mL
80 mM 0.0494 mL 0.2468 mL 0.4936 mL 1.2340 mL
100 mM 0.0395 mL 0.1974 mL 0.3949 mL 0.9872 mL
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Cbz-NH-PEG1-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cbz-NH-PEG1-CH2COOH1260092-43-0PROTAC LinkersInhibitorinhibitorinhibit

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