2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. CD1530

CD1530 is a selective RARγ agonist with an Kd of 150 nM. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma.

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CD1530 Chemical Structure

CD1530 Chemical Structure

CAS No. : 107430-66-0

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5 mg USD 110 In-stock
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50 mg USD 810 In-stock
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Based on 1 publication(s) in Google Scholar

CD1530 Related Antibodies

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Description

CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].

Molecular Weight

398.49

Formula

C27H26O3
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(O)C1=CC=C(C2=CC=C3C=C(O)C(C4(C5)CC6CC5CC(C6)C4)=CC3=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (250.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5095 mL 12.5474 mL 25.0947 mL
5 mM 0.5019 mL 2.5095 mL 5.0189 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5095 mL 12.5474 mL 25.0947 mL 62.7368 mL
5 mM 0.5019 mL 2.5095 mL 5.0189 mL 12.5474 mL
10 mM 0.2509 mL 1.2547 mL 2.5095 mL 6.2737 mL
15 mM 0.1673 mL 0.8365 mL 1.6730 mL 4.1825 mL
20 mM 0.1255 mL 0.6274 mL 1.2547 mL 3.1368 mL
25 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.5095 mL
30 mM 0.0836 mL 0.4182 mL 0.8365 mL 2.0912 mL
40 mM 0.0627 mL 0.3137 mL 0.6274 mL 1.5684 mL
50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.2547 mL
60 mM 0.0418 mL 0.2091 mL 0.4182 mL 1.0456 mL
80 mM 0.0314 mL 0.1568 mL 0.3137 mL 0.7842 mL
100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.6274 mL
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CD1530 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD1530107430-66-0CD 1530CD-1530RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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