2. Membrane Transporter/Ion Channel
  3. CFTR
  4. CFTR corrector 4

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

For research use only. We do not sell to patients.

CFTR corrector 4 Chemical Structure

CFTR corrector 4 Chemical Structure

CAS No. : 1918142-34-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 261 In-stock
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10 mM * 1 mL in DMSO USD 261 In-stock
Solid
5 mg USD 220 In-stock
10 mg USD 340 In-stock
25 mg USD 680 In-stock
50 mg USD 1090 In-stock
100 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

CFTR corrector 4 Related Antibodies

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Description

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].

IC50 & Target

EC50:130 nM (CFTR)[1]
In Vitro

CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay[1].
CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CFTR corrector 4 Related Antibodies
Molecular Weight

539.52

Formula

C29H27F2NO7
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)N[C@@H]4C[C@H](C5=CC=C(OC)C(OC)=C5)OC6=CC(OC)=CC=C46
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (203.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8535 mL 9.2675 mL 18.5350 mL
5 mM 0.3707 mL 1.8535 mL 3.7070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8535 mL 9.2675 mL 18.5350 mL 46.3375 mL
5 mM 0.3707 mL 1.8535 mL 3.7070 mL 9.2675 mL
10 mM 0.1853 mL 0.9267 mL 1.8535 mL 4.6337 mL
15 mM 0.1236 mL 0.6178 mL 1.2357 mL 3.0892 mL
20 mM 0.0927 mL 0.4634 mL 0.9267 mL 2.3169 mL
25 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
30 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5446 mL
40 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1584 mL
50 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
60 mM 0.0309 mL 0.1545 mL 0.3089 mL 0.7723 mL
80 mM 0.0232 mL 0.1158 mL 0.2317 mL 0.5792 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4634 mL
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CFTR corrector 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFTR corrector 41918142-34-3CFTR corrector4CFTR corrector-4CFTRCystic fibrosis transmembrane conductance regulatorCysticFibrosisInhibitorinhibitorinhibit

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