Dicentrine

Name: Dicentrine
Brand: MedChemExpress
SKU: HY-N6969
Rating: 4.5 (1 reviews)

Cat. No.: HY-N6969 Purity: 98.25%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α₁-adrenoceptor antagonist which has effective against human hyperplastic prostates.

For research use only. We do not sell to patients.

Dicentrine Chemical Structure

CAS No. : 517-66-8

Size	Price	Stock	Quantity
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Dicentrine:

Dicentrine hydrochloride Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

α adrenergic receptor

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	8.8 μM Compound: 2	Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay	[PMID: 31403289]
HepG2	IC₅₀	> 10 μM Compound: 2	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay	[PMID: 31403289]
HL-60	IC₅₀	3.7 μM Compound: 2	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay	[PMID: 31403289]
MCF7	IC₅₀	> 10 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay	[PMID: 31403289]
MRC5	IC₅₀	> 10 μM Compound: 2	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay	[PMID: 31403289]

Molecular Weight

339.39

Formula

C₂₀H₂₁NO₄

CAS No.

517-66-8

Appearance

Solid

Color

Off-white to light brown

SMILES

CN1[C@]2([H])C3=C(C4=C(OCO4)C=C3CC1)C5=C(C=C(OC)C(OC)=C5)C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (29.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9465 mL	14.7323 mL	29.4646 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL
10 mM	0.2946 mL	1.4732 mL	2.9465 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (2.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (2.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (2.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (253 KB) HNMR (271 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Sheu-Meei Yu, et al. Effects of dicentrine, a novel α1-adrenoceptor antagonist, on human hyperplastic prostates. European Journal of Pharmacology. 1994 Jan; 252(1):29-34.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9465 mL	14.7323 mL	29.4646 mL	73.6616 mL
	5 mM	0.5893 mL	2.9465 mL	5.8929 mL	14.7323 mL
	10 mM	0.2946 mL	1.4732 mL	2.9465 mL	7.3662 mL
	15 mM	0.1964 mL	0.9822 mL	1.9643 mL	4.9108 mL
	20 mM	0.1473 mL	0.7366 mL	1.4732 mL	3.6831 mL
	25 mM	0.1179 mL	0.5893 mL	1.1786 mL	2.9465 mL

Dicentrine Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicentrine517-66-8Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Dicentrine

Customer Review

Other Forms of Dicentrine:

Dicentrine Related Antibodies

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Biological Activity

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References

Customer Review

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Complete Stock Solution Preparation Table

Dicentrine Related Classifications

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