2. Gene
  3. TSPAN2 - tetraspanin 2 Gene

TSPAN2 - tetraspanin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NET3; TSN2; TSPAN-2

Gene ID: 10100 | Gene type: protein coding

About TSPAN2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:115,048,011-115,089,503 (from NCBI)

This gene has 4 transcripts (splice variants), 269 orthologues and 32 paralogues. Broad expression in endometrium (RPKM 16.8), urinary bladder (RPKM 10.7) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

TSPAN2 Products(3)

mRNA Protein Name
NM_001308315.2 NP_001295244.1 tetraspanin-2 isoform 2
NM_001308316.2 NP_001295245.1 tetraspanin-2 isoform 3
NM_005725.6 NP_005716.2 tetraspanin-2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25814554 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN2 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (10 - 214)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

tetraspanin-2

new EST tetraspan 3

TSPAN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TSPAN2 O60636 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra
TSPAN2 O60636 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
TSPAN2 O60636 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
TSPAN2 O60636 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra
TSPAN2 O60636 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
TSPAN2 O60636 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
TSPAN2 O60636 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
TSPAN2 O60636 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
TSPAN2 O60636 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
TSPAN2 O60636 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 DCBLD2 Homo sapiens Q96PD2-2
Validated Y2H
32296183
Intra
TSPAN2 O60636 DCBLD2 Homo sapiens Q96PD2-2
Y2H Array
32296183
Intra
TSPAN2 O60636 DCBLD2 Homo sapiens Q96PD2-2
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 ATP1B4 Homo sapiens Q9UN42
Validated Y2H
32296183
Intra
TSPAN2 O60636 ATP1B4 Homo sapiens Q9UN42
Y2H Array
32296183
Intra
TSPAN2 O60636 ATP1B4 Homo sapiens Q9UN42
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
TSPAN2 O60636 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
TSPAN2 O60636 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
TSPAN2 O60636 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
TSPAN2 O60636 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 TSPAN31 Homo sapiens Q12999
Validated Y2H
32296183
Intra
TSPAN2 O60636 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra
TSPAN2 O60636 CLEC14A Homo sapiens Q86T13
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 CLEC14A Homo sapiens Q86T13
Y2H Array
32296183
Intra
TSPAN2 O60636 CLEC14A Homo sapiens Q86T13
Validated Y2H
32296183
Intra
TSPAN2 O60636 KDELR3 Homo sapiens O43731-2
Y2H Array
32296183
Intra
TSPAN2 O60636 KDELR3 Homo sapiens O43731-2
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
TSPAN2 O60636 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
TSPAN2 O60636 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
TSPAN2 O60636 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
TSPAN2 O60636 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra
TSPAN2 O60636 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra
TSPAN2 O60636 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra
TSPAN2 O60636 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
TSPAN2 O60636 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
TSPAN2 O60636 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 F13A1 Homo sapiens P00488
Y2H Array
32814053
Intra
TSPAN2 O60636 F13A1 Homo sapiens P00488
Y2H Pooling
32814053
Intra
TSPAN2 O60636 F13A1 Homo sapiens P00488
Validated Y2H
32814053
Intra
TSPAN2 O60636 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
TSPAN2 O60636 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
TSPAN2 O60636 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
TSPAN2 O60636 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
TSPAN2 O60636 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 ABHD16A Homo sapiens O95870
Validated Y2H
32296183
Intra
TSPAN2 O60636 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
TSPAN2 O60636 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
TSPAN2 O60636 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
TSPAN2 O60636 ZFYVE27 Homo sapiens Q5T4F4
Validated Y2H
32296183
Intra
TSPAN2 O60636 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
TSPAN2 O60636 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 IFNGR2 Homo sapiens P38484
Validated Y2H
32296183
Intra
TSPAN2 O60636 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
TSPAN2 O60636 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
TSPAN2 O60636 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
TSPAN2 O60636 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 GRB2 Homo sapiens P62993
Peptide Array
25814554
Intra
TSPAN2 O60636 GRB2 Homo sapiens P62993
BiFC
25814554
Intra
TSPAN2 O60636 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TSPAN2 O60636 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TSPAN2 O60636 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
TSPAN2 O60636 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
TSPAN2 O60636 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
TSPAN2 O60636 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
TSPAN2 O60636 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
TSPAN2 O60636 LEPROTL1 Homo sapiens O95214
Validated Y2H
32296183
Intra
TSPAN2 O60636 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
TSPAN2 O60636 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
TSPAN2 O60636 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
TSPAN2 O60636 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
TSPAN2 O60636 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
TSPAN2 O60636 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 PIK3R3 Homo sapiens Q92569
Pull Down
25814554
Intra
TSPAN2 O60636 PIK3R3 Homo sapiens Q92569
BiFC
25814554
Intra
TSPAN2 O60636 PIK3R3 Homo sapiens Q92569
Peptide Array
25814554
Intra
TSPAN2 O60636 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
TSPAN2 O60636 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TSPAN2 O60636 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Migraine, Familial Hemiplegic, 2

FHM2

Mhp2

Migraine, Familial Basilar

Familial Hemiplegic Migraine 2

Familial Hemiplegic Migraine-2

Familiar Basilar Migraine

Migraine, Hemiplegic, Familial, Type 2
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Clonorchiasis

Oriental Liver Fluke Disease

Clonorchis Liver Infection

Clonorchiosis

Chinese Liver Fluke Disease

Hepatic Distomiasis Due To Clonorchis Sinensis

Infection Due To Clonorchis Sinensis

Hepatic Distomiasis

Hepatic Distomatosis

Chinese Liver Fluke Disorder

Oriental Liver Fluke Disorder

Clonorchis Infestation

Chinese Liver Fluke Infestation

Liver Fluke Disease Due To Clonorchis Sinensis

Oriental Liver Fluke Infestation
Migraine, Familial Hemiplegic, 3

FHM3

Familial Hemiplegic Migraine 3

Mhp3

Migraine, Hemiplegic, Familial, Type 3
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15165 TSPAN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TSPAN2 RGD RGD:620982
Bos taurus TSPAN2 VGNC VGNC:36435
Macaca mulatta TSPAN2 VGNC VGNC:79264
Felis catus TSPAN2 VGNC VGNC:66630
Mus musculus TSPAN2 MGD MGI:1917997
Canis familiaris TSPAN2 VGNC VGNC:47918
Others TSPAN2 NCBI