SAXO1 - stabilizer of axonemal microtubules 1 Gene

Homo sapiens

Also known as FAM154A; C9orf138

Gene ID: 158297 | Gene type: protein coding

About SAXO1

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:18,927,650-19,049,339 (from NCBI)

This gene has 5 transcripts (splice variants), 135 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 15.1).

Summary

Enables microtubule binding activity. Involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Located in microtubule Cytoskeleton and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]

SAXO1 Products(3)

mRNA	Protein	Name
NM_001287049.2	NP_001273978.1	stabilizer of axonemal microtubules 1 isoform b
NM_001287050.2	NP_001273979.1	stabilizer of axonemal microtubules 1 isoform c
NM_153707.4	NP_714918.2	stabilizer of axonemal microtubules 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	25673876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23088713	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cold	IDA IDA: Inferred from direct assay	25673876	GOA
involved in cold acclimation	IDA IDA: Inferred from direct assay	25673876	GOA
involved in positive regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25673876	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	25673876	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonemal microtubule	IDA IDA: Inferred from direct assay	25673876	GOA
located in centriole	IDA IDA: Inferred from direct assay	25673876	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	25673876	GOA
located in motile cilium	IDA IDA: Inferred from direct assay	25673876	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	25673876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAXO1 Protein Structure

STOP

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

stabilizer of axonemal microtubules 1

4930500O09Rik

SAXO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAXO1	Q8IYX7	IQUB	Homo sapiens	Q8NA54	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	VPS28	Homo sapiens	Q548N1	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	NUDT22	Homo sapiens	Q9BRQ3	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	TNK1	Homo sapiens	Q13470-2	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	TNK1	Homo sapiens	Q13470-2	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	CPNE7	Homo sapiens	Q9UBL6-2	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Cross	SAXO1	Q8IYX7	Hoxa1	Mus musculus	P09022	BiFC	23088713
Intra	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	BEGAIN	Homo sapiens	Q9BUH8	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	SAXO1	Q8IYX7	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	SAXO1	Q8IYX7	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	ZMYND19	Homo sapiens	Q96E35	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	SAXO1	Q8IYX7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	GLYCTK	Homo sapiens	Q8IVS8	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	SAXO1	Q8IYX7	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Y2H Array	31515488
Intra	SAXO1	Q8IYX7	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	CRK	Homo sapiens	P46108	Y2H Array	25416956
Intra	SAXO1	Q8IYX7	CRK	Homo sapiens	P46108	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	OSGIN1	Homo sapiens	Q9UJX0	Y2H Prey Pooling	25416956
Intra	SAXO1	Q8IYX7	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
Intra	SAXO1	Q8IYX7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	SAXO1	Q8IYX7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12461	SAXO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SAXO1	VGNC	VGNC:34301
Mus musculus	SAXO1	MGD	MGI:1923061
Canis familiaris	SAXO1	VGNC	VGNC:45878
Macaca mulatta	SAXO1	VGNC	VGNC:77114
Rattus norvegicus	SAXO1	RGD	RGD:1583685
Felis catus	SAXO1	VGNC	VGNC:64883

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