Akt1 - thymoma viral proto-oncogene 1 Gene

Mus musculus

Also known as Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha

Gene ID: 11651 | Gene type: protein coding

About Akt1

Chromosome 12: 112,620,255-112,641,318 reverse strand.GRCm39:CM001005.3

This gene has 9 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 60 phenotypes. Ubiquitous expression in adrenal adult (RPKM 14.9), limb E14.5 (RPKM 84.5) and 28 other tissues.

Summary

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), Insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Akt1 Products(5)

mRNA	Protein	Name
NM_001409450.1	NP_001396379.1	RAC-alpha serine/threonine-protein kinase isoform 3
NM_009652.4	NP_033782.1	RAC-alpha serine/threonine-protein kinase isoform 1
NM_001409449.1	NP_001396378.1	RAC-alpha serine/threonine-protein kinase isoform 1
NM_001165894.2	NP_001159366.1	RAC-alpha serine/threonine-protein kinase isoform 2
NM_001331107.2	NP_001318036.1	RAC-alpha serine/threonine-protein kinase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IDA IDA: Inferred from direct assay	23886629	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12791994	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14730361	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22057101	MGI
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	11784871	MGI
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	10454575	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	22057101	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	10983986	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	15713628	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	12869584	MGI
involved in behavioral response to pain	IGI IGI: Inferred from genetic interaction	31874168	MGI
acts upstream of or within cellular response to decreased oxygen levels	IDA IDA: Inferred from direct assay	24875179	MGI
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	21712384	MGI
acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	23610142	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	19744960	MGI
acts upstream of or within cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	17715136	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	19139280	MGI
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	17715136	MGI
acts upstream of or within cellular response to peptide	IDA IDA: Inferred from direct assay	23793062	MGI
acts upstream of or within cellular response to prostaglandin E stimulus	IDA IDA: Inferred from direct assay	23479225	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
acts upstream of or within cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	25139353	MGI
acts upstream of or within execution phase of apoptosis	IDA IDA: Inferred from direct assay	12124386	MGI
acts upstream of or within positive effect gene expression	IMP IMP: Inferred from mutant phenotype	31272455	MGI
acts upstream of or within germ cell development	IDA IDA: Inferred from direct assay	12140361	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	19897600	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	19897600	MGI
acts upstream of or within glycogen cell differentiation involved in embryonic placenta development	IMP IMP: Inferred from mutant phenotype	12783884	MGI
acts upstream of or within glycogen metabolic process	IMP IMP: Inferred from mutant phenotype	12783884	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	14730361	MGI
involved in inflammatory response	IGI IGI: Inferred from genetic interaction	31874168	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	20889126	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9415393	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	11784871	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	32439763	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	12783884	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	24740015	MGI
acts upstream of or within mammalian oogenesis stage	IMP IMP: Inferred from mutant phenotype	34635817	MGI
acts upstream of or within maternal placenta development	IMP IMP: Inferred from mutant phenotype	12783884	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11282895	MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18977203	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	19933931	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19911006	MGI
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	18977203	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	19208758	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16513828	MGI
acts upstream of or within peripheral nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	20448149	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	15249583	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	23871832	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18292230	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	15713641	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15937334	MGI
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	9415393	MGI
acts upstream of or within positive regulation of sodium ion transport	IDA IDA: Inferred from direct assay	17715136	MGI
acts upstream of or within positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	17715136	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18762576	MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15937334	MGI
acts upstream of or within protein catabolic process	IDA IDA: Inferred from direct assay	12145204	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12145204	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	20333297	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	12145204	MGI
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	18977203	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	24101522	MGI
acts upstream of or within regulation of neuron projection development	IDA IDA: Inferred from direct assay	21976490	MGI
involved in regulation of neuron projection development	IDA IDA: Inferred from direct assay	19778506	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	26844834	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	26844834	MGI
acts upstream of or within regulation of protein localization	IDA IDA: Inferred from direct assay	17715136	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	9415393	MGI
acts upstream of or within response to food	IDA IDA: Inferred from direct assay	16513828	MGI
involved in response to heat	IGI IGI: Inferred from genetic interaction	31874168	MGI
involved in response to hormone	IDA IDA: Inferred from direct assay	16357133	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	18762576	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	19596798	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12124386	MGI
located in cytosol	IDA IDA: Inferred from direct assay	28930673	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26844834	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26844834	MGI
is active in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	30504268	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	16116448	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18388859	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15775979	MGI
located in spindle	IDA IDA: Inferred from direct assay	15509711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt1 Protein Structure

PH_PKB

STKc_PKB_alpha

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

RAC-alpha serine/threonine-protein kinase

AKT1 kinase	Akt1m protein
PKB alpha	RAC-PK-alpha
protein kinase B-alpha	proto-oncogene c-AKT
related to A and C kinases	tumor rejection antigen peptide pRLib

Related Agents

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15186	Ipatasertib		99.88%	Phase 4
HY-N0004	Oridonin	Inhibitor	99.89%	Phase 4
HY-15431	Capivasertib	Inhibitor	99.95%	Phase 3
HY-15186A	Ipatasertib dihydrochloride	Inhibitor	99.27%	Phase 3
HY-10358	MK-2206 dihydrochloride		99.99%	Phase 2
HY-19719	Miransertib	Inhibitor	99.32%	Phase 2
HY-15727	Afuresertib	Inhibitor	99.53%	Phase 2
HY-15965	Uprosertib	Inhibitor	99.74%	Phase 2
HY-19934A	Pifusertib hydrochloride		96.71%	Phase 2
HY-15727A	Afuresertib hydrochloride	Inhibitor	99.95%	Phase 2
HY-19719A	Miransertib hydrochloride	Inhibitor	99.74%	Phase 2
HY-108232	MK-2206		/	Phase 2
HY-19934	Pifusertib		/	Phase 2
HY-10357	MK-2206 free base		/	Phase 2
HY-15965A	Uprosertib hydrochloride	Inhibitor	/	Phase 2
HY-10249	GSK-690693		98.46%	Phase 1
HY-100018	BAY1125976	Inhibitor	99.52%	Phase 1
HY-16071	AT13148	Inhibitor	99.21%	Phase 1
HY-100501	M2698	Inhibitor	99.87%	Phase 1
HY-137458	Vevorisertib	Inhibitor	/	Phase 1
HY-15186C	Ipatasertib tosylate		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (67)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18749	SC79	Activator	≥98.0%	Unkown
HY-10355	AKT inhibitor VIII		98.97%	Unkown
HY-107738	Guggulsterone		99.95%	Unkown
HY-10425	A-443654	Inhibitor	99.71%	Unkown
HY-11005	BX-912		99.13%	Unkown
HY-N1435	Oroxin B		99.71%	Unkown
HY-13254	A-674563	Inhibitor	99.87%	Unkown
HY-124379	TPCK		98.55%	Unkown
HY-12059	AT7867	Inhibitor	99.88%	Unkown
HY-133120	INY-03-041	Inhibitor	99.74%	Unkown
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	99.13%	Unkown
HY-151504	ALM301	Inhibitor	99.65%	Unkown
HY-18271	CaMKII-IN-1	Inhibitor	98.02%	Unkown
HY-160093	SQLE-IN-1		98.82%	Unkown
HY-145282	MS170	Inhibitor	99.72%	Unkown
HY-13254A	A-674563 hydrochloride	Inhibitor	99.86%	Unkown
HY-12059A	AT7867 dihydrochloride	Inhibitor	99.75%	Unkown
HY-151613A	MS15 TFA	Degrader	99.86%	Unkown
HY-16666	3CAI	Inhibitor	98.32%	Unkown
HY-50862	Akt1/Akt2-IN-1	Inhibitor	99.30%	Unkown
HY-19982	AKT-IN-6	Inhibitor	99.08%	Unkown
HY-119016	SK1-I	Inhibitor	98.47%	Unkown
HY-126257	AKT-IN-3	Inhibitor	99.29%	Unkown
HY-133120A	INY-03-041 trihydrochloride	Inhibitor	99.27%	Unkown
HY-107586	Demethylasterriquinone B1	Activator	98.10%	Unkown
HY-134903	(32-Carbonyl)-RMC-5552	Inhibitor	95.41%	Unkown
HY-119016A	SK1-I hydrochloride	Inhibitor	99.49%	Unkown
HY-N8122	24-Methylenecycloartanyl ferulate	Inhibitor	98.05%	Unkown
HY-130985	9-Decyn-1-ol		/	Unkown
HY-151613	MS15	Inhibitor	/	Unkown
HY-132302	Hu7691	Inhibitor	/	Unkown
HY-123390	DB07107	Inhibitor	/	Unkown
HY-129119	Akt1/Akt2-IN-2		98.57%	Unkown
HY-146459	Akt1-IN-1	Inhibitor	99.74%	Unkown
HY-148868	Akt1&PKA-IN-1	Inhibitor	/	Unkown
HY-148868A	Akt1&PKA-IN-2	Inhibitor	/	Unkown
HY-161321	PTP1B-IN-24		95.01%	Unkown
HY-W013816	Dipentyl phthalate		99.42%	Unkown
HY-W998345	SMART1	Inhibitor	/	Unkown
HY-145281	MS98	Inhibitor	/	Unkown
HY-112148	AKT-IN-2	Inhibitor	/	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-138767	AKT-IN-5	Inhibitor	/	Unkown
HY-143611	AKT-IN-8	Inhibitor	/	Unkown
HY-145244	APN/AKT-IN-1	Inhibitor	/	Unkown
HY-147937	AKT-IN-13	Inhibitor	/	Unkown
HY-153640	AKT-IN-14	Inhibitor	/	Unkown
HY-153640A	AKT-IN-14 free base	Inhibitor	/	Unkown
HY-154960	Tubulin/AKT1-IN-1		/	Unkown
HY-161438	Akt1-IN-3	Inhibitor	/	Unkown
HY-161439	Akt1-IN-4	Inhibitor	/	Unkown
HY-162285	Anticancer agent 189	Inhibitor	/	Unkown
HY-163577	Akt1-IN-5	Inhibitor	/	Unkown
HY-163578	Akt1-IN-6	Inhibitor	/	Unkown
HY-163579	Akt1-IN-7	Inhibitor	/	Unkown
HY-168049	ZLY06	Agonist	/	Unkown
HY-168205	HSP90-IN-33		/	Unkown
HY-P5910	Azurin p28 peptide	Inducer	/	Unkown
HY-P5910A	Azurin p28 peptide TFA	Inducer	/	Unkown
HY-RS00542	AKT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00543	Akt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00544	Akt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00545	AKT1S1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W750451	Reptoside		/	Unkown
HY-16032	Akt1-IN-2	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akt1	NCBI	NCBI:207

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