2. Gene
  3. Jak1 - Janus kinase 1 Gene

Jak1 - Janus kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as BAP004; C130039L05Rik

Gene ID: 16451 | Gene type: protein coding

About Jak1

Chromosome 4: 101,009,564-101,122,479 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues.

Summary

Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Jak1 Products(2)

mRNA Protein Name
NM_146145.2 NP_666257.2 tyrosine-protein kinase JAK1 isoform 1
NM_013567.1 NP_038595.1 tyrosine-protein kinase JAK1 isoform 2

Jak1 Protein Structure

FERM_F1

FERM_F1: cl39717 (51 - 128)

FERM_F2

FERM_F2: pfam18377 (146 - 276)

FERM_C_JAK1

FERM_C_JAK1: cd13332 (281 - 425)

SH2_Jak1

SH2_Jak1: cd10378 (425 - 525)

PTK_Jak1_rpt1

PTK_Jak1_rpt1: cd05077 (581 - 844)

PTKc_Jak1_rpt2

PTKc_Jak1_rpt2: cd05079 (868 - 1151)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1153 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK1

JAK-1

Related Agents

Approval
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-117287 Deucravacitinib Inhibitor 99.87% Unkown
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.97% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.98% Yes
HY-18300 Filgotinib Inhibitor 99.68% Yes
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-109053 Delgocitinib Inhibitor 99.87% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.63% Unkown
HY-13577 Oclacitinib Inhibitor 99.59% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Phase
HY-10961 Momelotinib Inhibitor 99.37% Phase 3
HY-16997 Itacitinib Inhibitor 99.97% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-112708 Brepocitinib Inhibitor 98.64% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.06% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-16997A Itacitinib adipate Inhibitor 99.18% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-50856S Deuruxolitinib Inhibitor 99.18% Phase 3
HY-10963 Momelotinib mesylate Inhibitor / Phase 3
HY-10193 AZD-1480 Inhibitor 99.91% Phase 2
HY-107361 Golidocitinib Inhibitor 99.75% Phase 2
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.86% Phase 2
HY-19631A Ilginatinib Inhibitor 99.94% Phase 2
HY-16755 Solcitinib Inhibitor 99.51% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-126294 Londamocitinib Inhibitor 98.98% Phase 1
HY-101024 PF-06263276 Inhibitor 99.38% Phase 1
Pre-clinical Phase
Bioactive Molecules (51)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W063968 RO8191 Activator ≥99.0% Unkown
HY-14435 Pyridone 6 Inhibitor 98.13% Unkown
HY-151385 VVD-118313 Inhibitor 99.75% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.89% Unkown
HY-100895 SAR-20347 Inhibitor 97.12% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.90% Unkown
HY-108264 TCS 21311 Inhibitor 99.18% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.23% Unkown
HY-130247 Flonoltinib Inhibitor 99.79% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-131906 JAK2-IN-7 Inhibitor 99.15% Unkown
HY-130247A Flonoltinib TFA Inhibitor 99.77% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-139423 JAK1-IN-8 Inhibitor ≥95.0% Unkown
HY-151385A (R,R)-VVD-118313 Inhibitor 99.54% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-152080 TUL01101 Inhibitor 99.71% Unkown
HY-156409 ABBV-712 Inhibitor 99.94% Unkown
HY-116505 JAK1-IN-4 Inhibitor 99.26% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.43% Unkown
HY-153440 JAK-IN-25 Inhibitor 98.44% Unkown
HY-W394903 GS-829845 Inhibitor 99.91% Unkown
HY-15814 HG-7-85-01 Inhibitor 99.94% Unkown
HY-13450 ZM 449829 Inhibitor 99.73% Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-161259 JAK-IN-36 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-162248 JAK1/2-IN-1 Inhibitor / Unkown
HY-139649 Ten01 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-153566 JAK1-IN-10 Inhibitor / Unkown
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-161618 MJ04 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-143444 JAK-IN-20 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-100849 JAK 3i Inhibitor / Unkown
HY-W064657 Momelotinib dihydrochloride Inhibitor / Unkown
HY-12589A ZM39923 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-163653 Zemprocitinib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak1 NCBI NCBI:3716