EFNA5 - ephrin A5 Gene

Homo sapiens

Also known as AF1; EFL5; RAGS; EPLG7; GLC1M; LERK7

Gene ID: 1946 | Gene type: protein coding

About EFNA5

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:107,376,894-107,670,937 (from NCBI)

This gene has 5 transcripts (splice variants), 289 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 2.4), brain (RPKM 1.7) and 22 other tissues.

Summary

Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Eph Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

EFNA5 Products(2)

mRNA	Protein	Name
NM_001410773.1	NP_001397702.1	ephrin-A5 isoform 2 precursor
NM_001962.3	NP_001953.1	ephrin-A5 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	11519828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19836338	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in apoptotic process	IDA IDA: Inferred from direct assay	11870224	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	11870224	GOA
acts upstream of or within negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	23242526	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11870224	GOA
acts upstream of or within regulation of cell morphogenesis	IDA IDA: Inferred from direct assay	23242526	GOA
involved in regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	11870224	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11870224	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA5 Protein Structure

Ephrin

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

ephrin-A5

AL-1

EFNA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EFNA5	P52803	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	EFNA5	P52803	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	EFNA5	P52803	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	EFNA5	P52803	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	EFNA5	P52803	GPR151	Homo sapiens	Q8TDV0	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	EFNA5	P52803	GPR151	Homo sapiens	Q8TDV0	Y2H Array	32296183
Intra	EFNA5	P52803	TSPO2	Homo sapiens	Q5TGU0	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	EFNA5	P52803	TSPO2	Homo sapiens	Q5TGU0	Y2H Array	32296183
Intra	EFNA5	P52803	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	EFNA5	P52803	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	EFNA5	P52803	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	EFNA5	P52803	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	EFNA5	P52803	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	EFNA5	P52803	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	EFNA5	P52803	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	EFNA5	P52803	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	EFNA5	P52803	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	EFNA5	P52803	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	EFNA5	P52803	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	EFNA5	P52803	ACKR2	Homo sapiens	O00590	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	ACKR2	Homo sapiens	O00590	Y2H Array	32296183
Intra	EFNA5	P52803	EPHA7	Homo sapiens	Q15375	Anti Tag CoIP	33961781
Intra	EFNA5	P52803	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
Intra	EFNA5	P52803	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
Intra	EFNA5	P52803	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	EFNA5	P52803	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	EFNA5	P52803	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	EFNA5	P52803	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	EFNA5	P52803	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	EFNA5	P52803	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	EFNA5	P52803	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	EFNA5	P52803	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	EFNA5	P52803	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	SLC10A2	Homo sapiens	Q12908	Validated Y2H	32296183
Intra	EFNA5	P52803	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	EFNA5	P52803	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	EFNA5	P52803	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
Intra	EFNA5	P52803	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	EFNA5	P52803	HERPUD2	Homo sapiens	Q9BSE4	Validated Y2H	32296183
Intra	EFNA5	P52803	HERPUD2	Homo sapiens	Q9BSE4	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	HERPUD2	Homo sapiens	Q9BSE4	Y2H Array	32296183
Intra	EFNA5	P52803	EPHA4	Homo sapiens	P54764	Anti Tag CoIP	33961781
Intra	EFNA5	P52803	GPR161	Homo sapiens	Q8N6U8	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	GPR161	Homo sapiens	Q8N6U8	Validated Y2H	32296183
Intra	EFNA5	P52803	GPR161	Homo sapiens	Q8N6U8	Y2H Array	32296183
Intra	EFNA5	P52803	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	EFNA5	P52803	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	33961781
Intra	EFNA5	P52803	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	EFNA5	P52803	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	EFNA5	P52803	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	YIPF6	Homo sapiens	Q96EC8	Y2H Prey Pooling	32296183
Intra	EFNA5	P52803	YIPF6	Homo sapiens	Q96EC8	Y2H Array	32296183
Intra	EFNA5	P52803	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70379	Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc)	P52803 (Q21-N203)	≥95%
HY-P73012	Ephrin-A5/EFNA5 Protein, Human (HEK293, His)	P52803 (Q21-N203)	≥95%

Related Diseases

Diseases

Alias

Cortical Senile Cataract

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04196	EFNA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EFNA5	MGD	MGI:107444
Felis catus	EFNA5	VGNC	VGNC:102192
Rattus norvegicus	EFNA5	RGD	RGD:620391
Bos taurus	EFNA5	VGNC	VGNC:28358
Macaca mulatta	EFNA5	VGNC	VGNC:72168
Canis familiaris	EFNA5	VGNC	VGNC:53168
Others	EFNA5	NCBI

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