2. Gene
  3. Ghsr - growth hormone secretagogue receptor Gene

Ghsr - growth hormone secretagogue receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GHRP; GHS-R; Ghsr1a; C530020I22Rik

Gene ID: 208188 | Gene type: protein coding

About Ghsr

Chromosome 3: 27,425,500-27,432,159 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 218 orthologues, 14 paralogues and is associated with 15 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity; identical protein binding activity; and peptide hormone binding activity. Involved in adult feeding behavior and positive regulation of appetite. Acts upstream of or within several processes, including cellular response to Insulin stimulus; growth hormone secretion; and positive regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cell surface; membrane raft; and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and trachea. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghsr Products(1)

mRNA Protein Name
NM_177330.4 NP_796304.1 growth hormone secretagogue receptor type 1

Ghsr Protein Structure

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 331)

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 69)

7tmA_GHSR

7tmA_GHSR: cd15131 (76 - 101)

7tmA_GHSR

7tmA_GHSR: cd15131 (114 - 144)

7tmA_GHSR

7tmA_GHSR: cd15131 (156 - 178)

7tmA_GHSR

7tmA_GHSR: cd15131 (207 - 236)

7tmA_GHSR

7tmA_GHSR: cd15131 (253 - 283)

7tmA_GHSR

7tmA_GHSR: cd15131 (299 - 324)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

growth hormone secretagogue receptor type 1

G-protein coupled receptor

GH-releasing peptide receptor

ghrelin receptor

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14734 Anamorelin Agonist 99.64% Unkown
HY-14734A Anamorelin hydrochloride Agonist 99.97% Unkown
HY-14820A Macimorelin acetate Agonist 98.96% Yes
HY-14820 Macimorelin Agonist / Unkown
HY-14734B Anamorelin Fumarate Agonist / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19884B Relamorelin TFA Agonist 99.89% Phase 3
HY-14903 Ulimorelin Agonist / Phase 3
HY-19884 Relamorelin Agonist / Phase 3
HY-19884A Relamorelin acetate Agonist / Phase 3
HY-50844 Ibutamoren Mesylate Agonist 99.86% Phase 2
HY-12584 PF-5190457 Inhibitor 98.34% Phase 2
HY-P0231 AZP-531 98.54% Phase 1
Pre-clinical Phase
Bioactive Molecules (42)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103007 TC-G-1008 Agonist 99.61% Unkown
HY-108699 TM-N1324 Agonist 99.91% Unkown
HY-U00433 JMV 2959 Antagonist 99.91% Unkown
HY-13964A YIL781 hydrochloride Antagonist 99.48% Unkown
HY-P1366 des-​Gln14-​Ghrelin 98.61% Unkown
HY-10957 L-692429 Agonist 99.90% Unkown
HY-P0089A Human growth hormone-releasing factor TFA 99.66% Unkown
HY-U00433A JMV 2959 hydrochloride Antagonist 98.09% Unkown
HY-15243 Capromorelin Tartrate Agonist 98.19% Unkown
HY-50760 L-692585 Agonist 99.32% Unkown
HY-13964 YIL781 Antagonist 99.68% Unkown
HY-P0089 Human growth hormone-releasing factor / Unkown
HY-10199A Ibutamoren Agonist / Unkown
HY-145364 Ghrelin receptor full agonist-2 Agonist / Unkown
HY-P1139 Cortistatin-8 Antagonist / Unkown
HY-115272 GSK894490A Agonist / Unkown
HY-116625 PF-04628935 Antagonist / Unkown
HY-113906 GSK1614343 Antagonist / Unkown
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human / Unkown
HY-14495A BMS-604992 free base Agonist / Unkown
HY-153095 PF-6870961 Agonist / Unkown
HY-117584 L-163255 free base / Unkown
HY-P10283 S1H Antagonist / Unkown
HY-P1306 Obestatin(rat) 98.73% Unkown
HY-137061 AZ-GHS-22 Antagonist / Unkown
HY-P3595 GHRF, porcine / Unkown
HY-14495 BMS-604992 Agonist / Unkown
HY-157556 BPP-2 / Unkown
HY-P1366A des-​Gln14-​Ghrelin TFA / Unkown
HY-P1432A K-(D-1-Nal)-FwLL-NH2 TFA Antagonist / Unkown
HY-153095A PF-6870961 hydrochloride Agonist / Unkown
HY-P3607 GHRF, bovine Activator / Unkown
HY-P1432 K-(D-1-Nal)-FwLL-NH2 Antagonist / Unkown
HY-P1306A Obestatin(rat) TFA / Unkown
HY-14495B BMS-604992 dihydrochloride Agonist / Unkown
HY-15242 Capromorelin Activator / Unkown
HY-113906A (αR,8aS)-GSK1614343 Antagonist 99.40% Unkown
HY-10957A L-692429 hydrochloride Agonist / Unkown
HY-111232 GSK894281 Agonist / Unkown
HY-N12348 Emoghrelin Activator / Unkown
HY-116959 SM-130686 / Unkown
HY-P10673 KwFwLL-NH2 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghsr NCBI NCBI:2693