2. Gene
  3. FAP - fibroblast activation protein alpha Gene

FAP - fibroblast activation protein alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAPA; SIMP; DPPIV; FAPalpha

Gene ID: 2191 | Gene type: protein coding

About FAP

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,170,684-162,243,445 (from NCBI)

This gene has 13 transcripts (splice variants), 127 orthologues and 6 paralogues. Biased expression in endometrium (RPKM 7.5), gall bladder (RPKM 5.1) and 11 other tissues.

Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

FAP Products(2)

mRNA Protein Name
NM_001291807.3 NP_001278736.1 prolyl endopeptidase FAP isoform 2
NM_004460.5 NP_004451.2 prolyl endopeptidase FAP isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
10593948 GOA
enables endopeptidase activity IDA
IDA: Inferred from direct assay
17317851 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
9065413 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
10455171 GOA
enables peptidase activity IDA
IDA: Inferred from direct assay
9688278 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
17317851 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16651416 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10455171 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
10593948 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
16651416 GOA
enables serine-type peptidase activity IMP
IMP: Inferred from mutant phenotype
9065413 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endothelial cell migration IDA
IDA: Inferred from direct assay
16651416 GOA
involved in negative regulation of extracellular matrix disassembly IDA
IDA: Inferred from direct assay
16651416 GOA
involved in negative regulation of extracellular matrix organization IDA
IDA: Inferred from direct assay
10455171 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
10455171 GOA
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
9065413 GOA
involved in proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
10593948 GOA
involved in regulation of collagen catabolic process IDA
IDA: Inferred from direct assay
10455171 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
17317851 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
9065413 GOA
part of peptidase complex IMP
IMP: Inferred from mutant phenotype
9065413 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10593948 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAP Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (106 - 473)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (555 - 757)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
Protein Preferred Names Protein Names

prolyl endopeptidase FAP

170 kDa melanoma membrane-bound gelatinase

FAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FAP Q12884 VIP Homo sapiens P01282
Protease Assay
21314817
Intra
FAP Q12884 GCG Homo sapiens P01275
Protease Assay
21314817
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAP Proteins

Cat. No. Product Name Accession Purity
HY-P72659 FAP Protein, Human (HEK293, His) Q12884-1 (L26-D760) ≥95%
HY-P77521 FAP Protein, Human (Biotinylated, HEK293, His) Q12884-1 (L26-D760) ≥95%
HY-P78121 FAP Protein, Human (Biotinylated, HEK293, His-Avi) Q12884-1 (L26-D760) ≥95%

Related Diseases

Diseases Alias
Breast Ductal Carcinoma

Ductal Breast Carcinoma

Duct Carcinoma

Carcinoma, Ductal

Mammary Ductal Carcinoma

Ductal Carcinoma
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Glioma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P3392 Zilganersen / Phase 3
HY-137331 FAPI-46 98.57% Phase 2
HY-147057 FAP-2286 99.54% Phase 1
HY-147057A FAP-2286 acetate / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99269 Sibrotuzumab ≥95.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101801 Ac-Gly-BoroPro ≥98.0% Unkown
HY-128643 FAPI-4 98.42% Unkown
HY-145983 Suc-Gly-Pro-AMC 99.16% Unkown
HY-153552A NH2-UAMC1110 TFA Inhibitor 99.89% Unkown
HY-145938 OncoFAP 99.77% Unkown
HY-147173 FAPI-74 99.84% Unkown
HY-47979A FAP-IN-2 TFA Inhibitor 99.92% Unkown
HY-P10131 3BP-3940 99.96% Unkown
HY-136641 NOTA-FAPI Inhibitor 99.26% Unkown
HY-47979 FAP-IN-2 Inhibitor 99.82% Unkown
HY-164316 FT-FAPI-12_9 95.29% Unkown
HY-139401 FAPI-34 99.67% Unkown
HY-128642 FAPI-2 98.94% Unkown
HY-164364A DOTAGA.(SA.FAPi)2 TFA Inhibitor 96.81% Unkown
HY-125366 ARI-3099 / Unkown
HY-164725 FAPI-mFS Inhibitor 99.78% Unkown
HY-D2363 DOTA.SA.FAPi TFA Inhibitor 99.26% Unkown
HY-P3441A 3BP-4089 TFA / Unkown
HY-P3392A Zilganersen sodium Inhibitor 91.43% Unkown
HY-164316A FT-FAPI-12_9 TFA 99.48% Unkown
HY-158326 FAP-IN-4 Inhibitor / Unkown
HY-D2281 [99mTc]Tc-6–1 / Unkown
HY-161074 PNT6555 96.55% Unkown
HY-128642A FAPI-2 TFA 98.05% Unkown
HY-161262 SB03178 Inhibitor / Unkown
HY-149860 FAP-IN-1 Inhibitor / Unkown
HY-146180 FSDD0I / Unkown
HY-146181 FSDD1I / Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-P3441 3BP-4089 / Unkown
HY-148361 Fluorogen binding modulator-1 / Unkown
HY-146182 FSDD3I / Unkown
HY-164364B DOTAGA.(SA.FAPi)2 analogue TFA Inhibitor / Unkown
HY-163079 AlF-PD-FAPI / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FAP RGD RGD:621253
Bos taurus FAP VGNC VGNC:28862
Canis familiaris FAP VGNC VGNC:40727
Felis catus FAP VGNC VGNC:62146
Macaca mulatta FAP VGNC VGNC:72613
Mus musculus FAP MGD MGI:109608
Macaca fascicularis FAP NCBI NCBI:102134935
Others FAP NCBI