Casr - calcium-sensing receptor Gene

Rattus norvegicus

Also known as PCaR1; RaKCaR

Gene ID: 24247 | Gene type: protein coding

About Casr

Primary_assembly 11: 64,235,251-64,304,811 forward strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 203 orthologues, 98 paralogues and is associated with 39 phenotypes. Restricted expression toward (RPKM 159.2).

Summary

Enables Integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and cellular chemical homeostasis. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]

Casr Products(2)

mRNA	Protein	Name
NM_016996.2	NP_058692.1	extracellular calcium-sensing receptor precursor
NM_001309638.1	NP_001296567.1	extracellular calcium-sensing receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	21969374	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20383739	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21084311	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	15084499	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22192592	RGD
involved in bile acid secretion	IDA IDA: Inferred from direct assay	11071898	RGD
involved in branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	20117086	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	21146545	RGD
involved in cellular response to hepatocyte growth factor stimulus	IEP IEP: Inferred from expression pattern	21088907	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21073657	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	22083546	RGD
involved in cellular response to peptide	IEP IEP: Inferred from expression pattern	22678567	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	21940515	RGD
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	7816802	RGD
involved in detection of calcium ion	IDA IDA: Inferred from direct assay	7816802	RGD
involved in fat pad development	IEP IEP: Inferred from expression pattern	21940515	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	12065312	RGD
involved in ossification	IMP IMP: Inferred from mutant phenotype	15084499	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22192592	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22192592	RGD
involved in positive regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	22098336	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12700162	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	22566534	RGD
involved in positive regulation of positive chemotaxis	IMP IMP: Inferred from mutant phenotype	20117086	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	22098336	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	20431039	RGD
involved in response to fibroblast growth factor	IEP IEP: Inferred from expression pattern	20431039	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	21488219	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	22312704	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19092814	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	15084499	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22517767	RGD
located in axon	IDA IDA: Inferred from direct assay	22517767	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	7724534	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	22517767	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21969374	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22517767	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	20052292	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casr Protein Structure

PBP1_CaSR

NCD3G

7tmC_CaSR

0
200
400
600
800
1000
1079 a.a.

Protein Preferred Names

Protein Names

extracellular calcium-sensing receptor

Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)

parathyroid Cell calcium-sensing receptor

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-70037	Cinacalcet	Agonist	99.97%	Yes
HY-70037A	Cinacalcet hydrochloride	Agonist	99.99%	Yes
HY-P1955A	Etelcalcetide hydrochloride	Activator	99.61%	Unkown
HY-17613	Evocalcet	Activator	98.39%	Unkown
HY-17397	Strontium Ranelate	Activator	99.99%	Unkown
HY-P1955	Etelcalcetide	Activator	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10007	NPS-2143	Antagonist	99.33%	Phase 2
HY-10167A	Tecalcet Hydrochloride	Modulator	99.66%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11095	NPS 2390	Inhibitor	98.83%	Unkown
HY-103320A	Calhex 231 hydrochloride	Inhibitor	99.81%	Unkown
HY-10171	NPS-2143 hydrochloride	Antagonist	99.80%	Unkown
HY-112171	γ-L-Glutamyl-L-alanine	Modulator	≥98.0%	Unkown
HY-N0546	Ligustroflavone	Antagonist	99.74%	Unkown
HY-12557	γ-Glutamylvaline	Activator	99.73%	Unkown
HY-109106A	Upacicalcet sodium		≥98.0%	Unkown
HY-122819	Calindol hydrochloride	Agonist	99.88%	Unkown
HY-15105	SB-423562	Antagonist	99.66%	Unkown
HY-50713	Calcium-Sensing Receptor Antagonists I	Antagonist	98.95%	Unkown
HY-107773	GSK3004774	Agonist	98.11%	Unkown
HY-117851	AC-265347	Agonist	99.97%	Unkown
HY-70037AS	Cinacalcet-d3 hydrochloride	Agonist	97.63%	Unkown
HY-109106	Upacicalcet		/	Unkown
HY-121584	Lycoperodine-1	Agonist	99.82%	Unkown
HY-109106B	(Rac)-Upacicalcet		≥95.0%	Unkown
HY-15106	SB-423557	Antagonist	/	Unkown
HY-70037S	Cinacalcet-D3	Agonist	/	Unkown
HY-14752	Ronacaleret	Antagonist	/	Unkown
HY-P4376	Gamma-Glu-Abu	Agonist	/	Unkown
HY-15104	Ronacaleret hydrochloride	Antagonist	/	Unkown
HY-103320	Calhex 231	Antagonist	/	Unkown
HY-153258	CaSR antagonist-1	Antagonist	/	Unkown
HY-14401	Encaleret	Antagonist	99.88%	Unkown
HY-161113	Z8554052021	Activator	/	Unkown
HY-10167	Tecalcet	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casr	NCBI	NCBI:846

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