2. Gene
  3. Atr - ataxia telangiectasia and Rad3 related Gene

Atr - ataxia telangiectasia and Rad3 related Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 245000 | Gene type: protein coding

About Atr

Chromosome 9: 95,739,650-95,833,834 forward strand.GRCm39:CM001002.3

This gene has 13 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 67 phenotypes. Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 3.4) and 21 other tissues.

Summary

Enables protein kinase activity. Involved in positive regulation of telomere maintenance via Telomerase and replication fork processing. Acts upstream of or within several processes, including DNA damage checkpoint signaling; embryo implantation; and protein phosphorylation. Located in XY body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and gonad. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr Products(1)

mRNA Protein Name
NM_019864.1 NP_063917.1 serine/threonine-protein kinase ATR

Atr Protein Structure

UME

UME: smart00802 (1118 - 1224)

NR_LBD

NR_LBD: cl11397 (1528 - 1606)

FAT

FAT: pfam02259 (1770 - 2091)

TEL1

TEL1: cl34875 (2122 - 2640)

PIKKc_ATR

PIKKc_ATR: cd00892 (2289 - 2563)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2641 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ATR

ataxia telangiectasia and Rad3-related protein

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-19323 Ceralasertib Inhibitor 99.76% Phase 3
HY-101566 Elimusertib Inhibitor 99.99% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-101566A Elimusertib hydrochloride Inhibitor 99.85% Phase 2
HY-13902 Berzosertib Inhibitor 99.70% Phase 1
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14731 VE-821 Inhibitor 98.32% Unkown
HY-15557 AZ20 Inhibitor 99.40% Unkown
HY-136270 Gartisertib Inhibitor 99.76% Unkown
HY-15520 CGK733 Inhibitor 99.83% Unkown
HY-15521 ETP-46464 Inhibitor 99.55% Unkown
HY-N6954 Garcinone C Activator 99.66% Unkown
HY-13816 NU6027 Inhibitor 99.04% Unkown
HY-P10280 ATR kinase substrate peptide Inhibitor 99.17% Unkown
HY-159480 AD1058 Inhibitor / Unkown
HY-153729 ATR-IN-29 Inhibitor / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-147566 ATR-IN-14 Inhibitor / Unkown
HY-153393 ATR-IN-21 Inhibitor / Unkown
HY-147190 ATR-IN-19 Inhibitor / Unkown
HY-144214 ATR-IN-10 Inhibitor / Unkown
HY-157767 Abd110 Inhibitor / Unkown
HY-147565 ATR-IN-13 Inhibitor / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-147569 ATR-IN-17 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-147568 ATR-IN-16 Inhibitor / Unkown
HY-161838 ICT10336 Inhibitor / Unkown
HY-147570 ATR-IN-18 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atr NCBI NCBI:545
Macaca fascicularis Atr NCBI NCBI:101926636
Rattus norvegicus Atr NCBI NCBI:685055
Macaca mulatta Atr NCBI NCBI:714443