1. Gene
  2. Atr - ataxia telangiectasia and Rad3 related Gene

Atr - ataxia telangiectasia and Rad3 related Gene

Mus musculus
Gene ID: 245000 | Gene type: protein coding

About Atr

Chromosome 9: 95,739,650-95,833,834 forward strand.GRCm39:CM001002.3

This gene has 13 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 67 phenotypes. Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 3.4) and 21 other tissues.

Summary

Enables protein kinase activity. Involved in positive regulation of telomere maintenance via Telomerase and replication fork processing. Acts upstream of or within several processes, including DNA damage checkpoint signaling; embryo implantation; and protein phosphorylation. Located in XY body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and gonad. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr Products(1)

mRNA Protein Name
NM_019864.1 NP_063917.1 serine/threonine-protein kinase ATR
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15680327 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15364958 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
12937170 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
15983387 MGI
acts upstream of or within DNA repair IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
10691732 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
10691732 MGI
involved in positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
26586427 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
15983387 MGI
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
29125140 MGI
Cellular Component GO Annotation Evidence Reference Source
part of ATR-ATRIP complex IPI
IPI: Inferred from physical interaction
11721054 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
29279380 MGI
located in XY body IDA
IDA: Inferred from direct assay
18316482 MGI
located in chromosome IDA
IDA: Inferred from direct assay
22549958 MGI
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29279380 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
31839538 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
29279380 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atr Protein Structure

UME

UME: smart00802 (1118 - 1224)

NR_LBD

NR_LBD: cl11397 (1528 - 1606)

FAT

FAT: pfam02259 (1770 - 2091)

TEL1

TEL1: cl34875 (2122 - 2640)

PIKKc_ATR

PIKKc_ATR: cd00892 (2289 - 2563)

  • 0
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  • 2000
  • 2641 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ATR

ataxia telangiectasia and Rad3-related protein

Orthologs Information

Species Symbol Source ID
Homo sapiens Atr NCBI NCBI:545
Macaca fascicularis Atr NCBI NCBI:101926636
Rattus norvegicus Atr NCBI NCBI:685055
Macaca mulatta Atr NCBI NCBI:714443