2. Gene
  3. Il10 - interleukin 10 Gene

Il10 - interleukin 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as If2a; IL10X

Gene ID: 25325 | Gene type: protein coding

About Il10

Primary_assembly 13: 42,472,839-42,477,313 forward strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 193 orthologues, 3 paralogues and is associated with 243 phenotypes. Biased expression in Spleen (RPKM 3.6), Thymus (RPKM 1.9) and 7 other tissues.

Summary

Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human IL10 (interleukin 10). [provided by Alliance of Genome Resources, Apr 2022]

Il10 Products(1)

mRNA Protein Name
NM_012854.2 NP_036986.2 interleukin-10 precursor

Il10 Protein Structure

IL10

IL10: cl02501 (13 - 125)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

interleukin-10

CSIF

IL-10

cytokine synthesis inhibitory factor

interferon 2a

Recombinant Il10 Proteins

Cat. No. Product Name Accession Purity
HY-P7098 IL-10 Protein, Rat P29456 (S19-N178) ≥95%
HY-P7098A IL-10 Protein, Rat (CHO) P29456 (S19-N178) ≥95%

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0809 Theophylline 99.89% Yes
HY-B0809R Theophylline (Standard) 99.99% Unkown
HY-107909 Theophylline sodium glycinate / Unkown
HY-B0809A Theophylline monohydrate / Unkown
HY-B0809B Theophylline sodium acetate / Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-110133 JTE-607 Inhibitor 99.27% Phase 2
HY-101019 Ossirene Inhibitor ≥98.0% Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-15507 VGX-1027 Inhibitor 99.76% Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141537 ABR-238901 Inhibitor 98.71% Unkown
HY-110353 CU-T12-9 Agonist 98.94% Unkown
HY-N0405 Orientin Inhibitor 99.73% Unkown
HY-N6607 Tryptanthrin 99.89% Unkown
HY-122586 BRD6989 99.56% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-113402A Gamma-glutamylcysteine TFA 95.20% Unkown
HY-N0600 Ginsenoside F3 Modulator 99.84% Unkown
HY-P1194 Spantide I Antagonist 99.85% Unkown
HY-101757 NO-prednisolone Agonist ≥99.0% Unkown
HY-23119 Sodium thiocyanate, GR, 99% ≥99.0% Unkown
HY-161440 SIK-IN-1 Inhibitor / Unkown
HY-N1940 β-Anhydroicaritin Inhibitor 99.09% Unkown
HY-147105 LRH-1 modulator-1 Modulator / Unkown
HY-147506 NOD2 antagonist 1 Antagonist 99.57% Unkown
HY-150232 MALT1-IN-11 Inhibitor / Unkown
HY-P1194A Spantide I TFA Antagonist 99.32% Unkown
HY-160040A Cobitolimod sodium Agonist / Unkown
HY-111164 CBS-3595 Inhibitor / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-149365 SIKs-IN-1 Inhibitor / Unkown
HY-155520 Antileishmanial agent-19 Inhibitor / Unkown
HY-160040 Cobitolimod Agonist / Unkown
HY-161441 SIK-IN-2 Inhibitor / Unkown
HY-161442 SIK-IN-3 Inhibitor / Unkown
HY-162600 CDK8-IN-15 Inhibitor / Unkown
HY-168091 YM-I-26 Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-RS06670 IL10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06671 Il10 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06672 Il10 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06673 IL10RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06674 IL10RB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-110133A JTE-607 free base Inhibitor / Unkown
HY-B0809S1 Theophylline-d3 / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5) Inhibitor ≥95.0% Unkown
HY-P990776 Vimekofusp / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il10 NCBI NCBI:3586
Canis familiaris Il10 NCBI NCBI:403628
Macaca fascicularis Il10 NCBI NCBI:102133450
Mus musculus Il10 NCBI NCBI:16153
Susscrofa domestica Il10 NCBI