Il10 - interleukin 10 Gene

Rattus norvegicus

Also known as If2a; IL10X

Gene ID: 25325 | Gene type: protein coding

About Il10

Primary_assembly 13: 42,472,839-42,477,313 forward strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 193 orthologues, 3 paralogues and is associated with 243 phenotypes. Biased expression in Spleen (RPKM 3.6), Thymus (RPKM 1.9) and 7 other tissues.

Summary

Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human IL10 (interleukin 10). [provided by Alliance of Genome Resources, Apr 2022]

Il10 Products(1)

mRNA	Protein	Name
NM_012854.2	NP_036986.2	interleukin-10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-10 receptor binding	IDA IDA: Inferred from direct assay	12405978	RGD
enables interleukin-10 receptor binding	IMP IMP: Inferred from mutant phenotype	19428551	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	20735828	RGD
involved in immune response	IMP IMP: Inferred from mutant phenotype	8484757	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	11813605	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19395591	RGD
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	8484757	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	28753520	RGD
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	17017555	RGD
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	17017555	RGD
involved in positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	25837415	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	24278397	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19424714	RGD
involved in response to carbon monoxide	IEP IEP: Inferred from expression pattern	20622590	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	16827395	RGD
involved in response to inactivity	IEP IEP: Inferred from expression pattern	17033197	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	18791499	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18791499	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19419978	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18787467	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il10 Protein Structure

IL10

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

interleukin-10

CSIF	IL-10
cytokine synthesis inhibitory factor	interferon 2a

Recombinant Il10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7098	IL-10 Protein, Rat	P29456 (S19-N178)	≥95%
HY-P7098A	IL-10 Protein, Rat (CHO)	P29456 (S19-N178)	≥95%

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0809	Theophylline	99.89%	Yes
HY-B0809R	Theophylline (Standard)	99.99%	Unkown
HY-107909	Theophylline sodium glycinate	/	Unkown
HY-B0809A	Theophylline monohydrate	/	Unkown
HY-B0809B	Theophylline sodium acetate	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-110133	JTE-607	Inhibitor	99.27%	Phase 2
HY-101019	Ossirene	Inhibitor	≥98.0%	Phase 2
HY-107390	AX-024	Inhibitor	99.29%	Phase 1
HY-15507	VGX-1027	Inhibitor	99.76%	Phase 1
HY-107390A	AX-024 hydrochloride	Inhibitor	99.75%	Phase 1
HY-101757	NO-prednisolone	Agonist	≥99.0%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990561	BT-063	Inhibitor	99.51%	Phase 2

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141537	ABR-238901	Inhibitor	98.71%	Unkown
HY-110353	CU-T12-9	Agonist	98.94%	Unkown
HY-N0405	Orientin	Inhibitor	99.73%	Unkown
HY-N6607	Tryptanthrin		99.89%	Unkown
HY-122586	BRD6989		99.56%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		95.20%	Unkown
HY-N0600	Ginsenoside F3	Modulator	99.84%	Unkown
HY-P1194	Spantide I	Antagonist	99.72%	Unkown
HY-23119	Sodium thiocyanate, GR, 99%		99.14%	Unkown
HY-N1940	β-Anhydroicaritin	Inhibitor	99.09%	Unkown
HY-161440	SIK-IN-1	Inhibitor	98.12%	Unkown
HY-147105	LRH-1 modulator-1	Agonist	98.04%	Unkown
HY-147105A	(+)-LRH-1 modulator-1		99.38%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-150232	MALT1-IN-11	Inhibitor	/	Unkown
HY-P1194A	Spantide I TFA	Antagonist	99.32%	Unkown
HY-124344	Avenanthramide C	Activator	98.90%	Unkown
HY-160040A	Cobitolimod sodium	Agonist	/	Unkown
HY-111164	CBS-3595	Inhibitor	/	Unkown
HY-143422	MALT1-IN-3	Inhibitor	/	Unkown
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	Unkown
HY-147527	CDK8-IN-5	Inhibitor	/	Unkown
HY-149365	SIKs-IN-1	Inhibitor	/	Unkown
HY-155520	Antileishmanial agent-19	Inhibitor	/	Unkown
HY-160040	Cobitolimod	Agonist	/	Unkown
HY-161441	SIK-IN-2	Inhibitor	/	Unkown
HY-161442	SIK-IN-3	Inhibitor	/	Unkown
HY-162600	CDK8-IN-15	Inhibitor	/	Unkown
HY-168091	YM-I-26	Inhibitor	/	Unkown
HY-168846	CDK8/19-IN-3	Inhibitor	/	Unkown
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	Unkown
HY-N14039	Pinus pinaster bark extract	Activator	/	Unkown
HY-N8249	Cynandione A	Activator	/	Unkown
HY-RS06670	IL10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06671	Il10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06672	Il10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06673	IL10RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06674	IL10RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-110133A	JTE-607 free base	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-B0809S1	Theophylline-d3		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990001	Anti-Mouse IL-10 Antibody (JES5-2A5)	Inhibitor	≥95.0%	Unkown
HY-P990776	Vimekofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il10	NCBI	NCBI:3586
Canis familiaris	Il10	NCBI	NCBI:403628
Macaca fascicularis	Il10	NCBI	NCBI:102133450
Mus musculus	Il10	NCBI	NCBI:16153
Susscrofa domestica	Il10	NCBI

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