HSPB7 - heat shock protein family B (small) member 7 Gene

Homo sapiens

Also known as cvHSP

Gene ID: 27129 | Gene type: protein coding

About HSPB7

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,014,029-16,019,594 (from NCBI)

This gene has 7 transcripts (splice variants), 256 orthologues and 8 paralogues. Biased expression in heart (RPKM 547.7) and fat (RPKM 156.2).

Summary

This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]

HSPB7 Products(8)

mRNA	Protein	Name
NM_001349682.2	NP_001336611.1	heat shock protein beta-7 isoform 1
NM_001349683.2	NP_001336612.1	heat shock protein beta-7 isoform 3
NM_001349685.2	NP_001336614.1	heat shock protein beta-7 isoform 4
NM_001349686.2	NP_001336615.1	heat shock protein beta-7 isoform 5
NM_001349687.2	NP_001336616.1	heat shock protein beta-7 isoform 6
NM_001349688.2	NP_001336617.1	heat shock protein beta-7 isoform 7
NM_001349689.2	NP_001336618.1	heat shock protein beta-7 isoform 8
NM_014424.5	NP_055239.1	heat shock protein beta-7 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14594798	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19464326	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19464326	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPB7 Protein Structure

HSP20

0
100
170 a.a.

Protein Preferred Names

Protein Names

heat shock protein beta-7

cardiovascular heat shock protein

HSPB7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPB7	Q9UBY9	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	UBXN1	Homo sapiens	Q04323-2	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	UBXN1	Homo sapiens	Q04323-2	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	PIP4K2B	Homo sapiens	P78356-2	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	PIP4K2B	Homo sapiens	P78356-2	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	C22orf15	Homo sapiens	Q8WYQ4-2	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	C22orf15	Homo sapiens	Q8WYQ4-2	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	HSPB7	Q9UBY9	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	HSPB7	Q9UBY9	SF3B4	Homo sapiens	Q15427	Validated Y2H	25416956
Intra	HSPB7	Q9UBY9	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	25416956
Intra	HSPB7	Q9UBY9	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Anti Tag CoIP	14594798
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Validated Y2H	32296183
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Y2H	14594798
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	FRET	14594798
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Validated Y2H	25416956
Intra	HSPB7	Q9UBY9	HSPB8	Homo sapiens	Q9UJY1	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	HSPB7	Q9UBY9	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	HSPB7	Q9UBY9	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	HSPB7	Q9UBY9	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	25416956
Intra	HSPB7	Q9UBY9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	HSPB7	Q9UBY9	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	25416956
Intra	HSPB7	Q9UBY9	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	25416956
Intra	HSPB7	Q9UBY9	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	CEP76	Homo sapiens	Q8TAP6	Y2H Array	25416956
Intra	HSPB7	Q9UBY9	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	HSPB7	Q9UBY9	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	HSPB7	Q9UBY9	FLNA	Homo sapiens	P21333-2	Anti Tag CoIP	28514442
Intra	HSPB7	Q9UBY9	FLNA	Homo sapiens	P21333-2	Y2H Array	32296183
Intra	HSPB7	Q9UBY9	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPB7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70929	PSG2 Protein, Human (His)	Q9UBY9 (M1-I170)	≥95%

Related Diseases

Diseases

Alias

Paraneoplastic Polyneuropathy

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Myopathy, Myofibrillar, 5

Myofibrillar Myopathy 5	MFM5
Myopathy, Myofibrillar, Filamin C-Related	Filaminopathy, Autosomal Dominant
Filaminopathy	Muscle Filaminopathy
Autosomal Dominant Filaminopathy	Mfm Filamin C-Related
Myopathy Myofibrillar Filamin C-Related	Myopathy, Myofibrillar, Type 5

Systolic Heart Failure

Heart Failure, Systolic

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06442	HSPB7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPB7	MGD	MGI:1352494
Rattus norvegicus	HSPB7	RGD	RGD:62021
Macaca mulatta	HSPB7	VGNC	VGNC:99972
Canis familiaris	HSPB7	VGNC	VGNC:52138
Felis catus	HSPB7	VGNC	VGNC:80236
Bos taurus	HSPB7	VGNC	VGNC:49068

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