ANG - angiogenin Gene

Homo sapiens

Also known as ALS9; RAA1; HEL168; RNASE4; RNASE5

Gene ID: 283 | Gene type: protein coding

About ANG

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,177-20,694,186 (from NCBI)

This gene has 3 transcripts (splice variants), 98 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

ANG Products(6)

mRNA	Protein	Name
NM_001097577.3	NP_001091046.1	angiogenin precursor
NM_001145.4	NP_001136.1	angiogenin precursor
NM_001385271.1	NP_001372200.1	angiogenin precursor
NM_001385272.1	NP_001372201.1	angiogenin precursor
NM_001385273.1	NP_001372202.1	angiogenin precursor
NM_001385274.1	NP_001372203.1	angiogenin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	2424496	GOA
enables actin binding	IDA IDA: Inferred from direct assay	7679494	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	9245697	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	10103013	GOA
enables peptide binding	IDA IDA: Inferred from direct assay	11782452	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2742853	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25372031	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	38718836	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9122172	GOA
enables tRNA-specific ribonuclease activity	IDA IDA: Inferred from direct assay	19332886	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	8448182	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	3470787	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	2479414	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12548285	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	17125737	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12548285	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	27518564	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	10103013	GOA
involved in negative regulation of translation in response to stress	IDA IDA: Inferred from direct assay	19332886	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	9122172	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	17125737	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	2646638	GOA
involved in rRNA transcription	IDA IDA: Inferred from direct assay	27518564	GOA
involved in rRNA transcription	IMP IMP: Inferred from mutant phenotype	15735021	GOA
involved in response to hormone	IDA IDA: Inferred from direct assay	10999833	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	10999833	GOA
involved in response to yeast	IDA IDA: Inferred from direct assay	12548285	GOA
involved in signaling	IDA IDA: Inferred from direct assay	2457905	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	20129916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of angiogenin-PRI complex	IDA IDA: Inferred from direct assay	3470787	GOA
part of angiogenin-PRI complex	IPI IPI: Inferred from physical interaction	3470787	GOA
located in basement membrane	IDA IDA: Inferred from direct assay	15166501	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	23047679	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27518564	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	29748193	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3663649	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	23047679	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10649442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANG Protein Structure

RnaseA

0
100
147 a.a.

Protein Preferred Names

Protein Names

angiogenin

RNase 5

Recombinant ANG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7503	Angiogenin Protein, Human	P03950 (Q25-P147)	≥95%
HY-P700644	Angiogenin Protein, Human (His)	P03950 (D26-P147)	≥95%

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9	ALS9
Sclerosis, Lateral, Amyotrophic, Type Type 9

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4	ALS4
Amyotrophic Lateral Sclerosis 4	Dhmn With Upper Motor Neuron Signs
Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs	Neuronopathy, Distal Hereditary Motor, With Pyramidal Features
Als 4	Distal Hereditary Motor Neuropathy With Pyramidal Features
Amyotrophic Lateral Sclerosis Juvenile 4	Neuronopathy Distal Hereditary Motor With Pyramidal Features
Sclerosis, Lateral, Amyotrophic, Type Type 4

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13948	Angiotensin II human		99.98%	Unkown
HY-13948A	Angiotensin II human acetate		99.81%	Unkown
HY-B0561	Spironolactone		99.66%	Yes
HY-B0202	Irbesartan		99.68%	Yes
HY-13948B	Angiotensin II human TFA		99.88%	Unkown
HY-B0935	Benzyl benzoate	Inhibitor	99.94%	Yes
HY-B0202A	Irbesartan hydrochloride		/	Unkown
HY-B0202R	Irbesartan (Standard)		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99116	Faricimab	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2983	Angiotensin-converting enzyme		/	Phase 4
HY-137455	Terevalefim	Activator	99.89%	Phase 3
HY-109041	Razuprotafib		≥98.0%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99330	Vanucizumab	Inhibitor	95.00%	Phase 2
HY-P99510	Zansecimab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12403	Talfirastide		99.91%	Yes
HY-P0216	A 779	Antagonist	98.59%	Unkown
HY-15477	YS-49		99.92%	Unkown
HY-P1236	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse	Inhibitor	98.56%	Unkown
HY-N0515	Ophiopogonin D		99.54%	Unkown
HY-151483	TK-129	Inhibitor	≥98.0%	Unkown
HY-15778A	AVE 0991 sodium salt	Agonist	98.75%	Unkown
HY-N7665	Prosaikogenin G		96.12%	Unkown
HY-12403A	Talfirastide acetate		99.87%	Yes
HY-P1415A	Norleual TFA		99.32%	Unkown
HY-147243	Ansornitinib	Inhibitor	98.04%	Unkown
HY-N2666	5α-Hydroxycostic acid	Inhibitor	95.03%	Unkown
HY-135795	1-Cyclohexyl-3-dodecyl urea	Inhibitor	≥98.0%	Unkown
HY-P1236A	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA	Inhibitor	/	Unkown
HY-15477A	YS-49 monohydrate		99.56%	Unkown
HY-102093A	ZD 7155		/	Unkown
HY-103247	EMD 66684	Antagonist	/	Unkown
HY-121313	Embusartan	Antagonist	/	Unkown
HY-129412	A-74273	Inhibitor	/	Unkown
HY-131162	Chymase		/	Unkown
HY-142694	DCN1-UBC12-IN-2	Inhibitor	/	Unkown
HY-162729	LSD1-IN-34	Inhibitor	/	Unkown
HY-163859	LSD1-IN-33	Inhibitor	/	Unkown
HY-169026	DCN1-IN-2	Inhibitor	/	Unkown
HY-B0202S2	Irbesartan-d6-1		/	Unkown
HY-P1415	Norleual		/	Unkown
HY-RS00684	ANG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W717329	EC33	Inhibitor	/	Unkown
HY-13948BS	Angiotensin II human-13C6,15N TFA		98.11%	Unkown
HY-167886	GA 0113	Antagonist	/	Unkown
HY-B0202AS	Irbesartan-d7 hydrochloride		/	Unkown
HY-B0202S3	Irbesartan-d7		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ANG	RGD	RGD:1594539
Mus musculus	ANG	MGD	MGI:88022
Canis familiaris	ANG	NCBI	NCBI:102153970
Macaca fascicularis	ANG	NCBI	NCBI:102118768
Canis lupus familiaris	ANG	NCBI
Macaca mulatta	ANG	NCBI
Others	ANG	NCBI

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