HOXC4 - homeobox C4 Gene

Homo sapiens

Also known as HOX3; cp19; HOX3E

Gene ID: 3221 | Gene type: protein coding

About HOXC4

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,016,888-54,056,030 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in kidney (RPKM 4.9), ovary (RPKM 2.4) and 16 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]

HOXC4 Products(2)

mRNA	Protein	Name
NM_014620.6	NP_055435.2	homeobox protein Hox-C4
NM_153633.3	NP_705897.1	homeobox protein Hox-C4

HOXC4 Protein Structure

Homeobox

0
100
200
264 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-C4

homeo box 3E

HOXC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32814053
Intra	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Y2H Pooling	32814053
Intra	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32814053
Intra	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	HOXC4	P09017	CSNK2A1	Homo sapiens	P68400	Validated Y2H	32296183
Intra	HOXC4	P09017	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	HOXC4	P09017	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	HOXC4	P09017	PPIB	Homo sapiens	P23284	Validated Y2H	32814053
Intra	HOXC4	P09017	PPIB	Homo sapiens	P23284	Y2H Pooling	32814053
Intra	HOXC4	P09017	PPIB	Homo sapiens	P23284	Y2H Array	32814053
Intra	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	HOXC4	P09017	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	HOXC4	P09017	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HOXC4	P09017	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HOXC4	P09017	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	HOXC4	P09017	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	HOXC4	P09017	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	HOXC4	P09017	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	HOXC4	P09017	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	HOXC4	P09017	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	HOXC4	P09017	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
Intra	HOXC4	P09017	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	HOXC4	P09017	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	HOXC4	P09017	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	HOXC4	P09017	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
Intra	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
Intra	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
Intra	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
Intra	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	HOXC4	P09017	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	HOXC4	P09017	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	HOXC4	P09017	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06317	HOXC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOXC4	MGD	MGI:96195
Bos taurus	HOXC4	VGNC	VGNC:29925
Felis catus	HOXC4	VGNC	VGNC:84031
Canis familiaris	HOXC4	VGNC	VGNC:41759
Rattus norvegicus	HOXC4	RGD	RGD:1586210

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