TSPAN33 - tetraspanin 33 Gene

Homo sapiens

Also known as PEN; PEN.; TSPAN-33

Gene ID: 340348 | Gene type: protein coding

About TSPAN33

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:129,144,707-129,169,699 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 32 paralogues. Broad expression in kidney (RPKM 45.5), lymph node (RPKM 15.7) and 20 other tissues.

Summary

Enables Enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]

TSPAN33 Products(1)

mRNA	Protein	Name
NM_178562.5	NP_848657.1	tetraspanin-33

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23091066	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23091066	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	30463011	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	23091066	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	23091066	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23091066	GOA
part of pore complex	IMP IMP: Inferred from mutant phenotype	30463011	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN33 Protein Structure

Tetraspannin

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

tetraspanin-33

penumbra

TSPAN33 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	26686862
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SHISA4	Homo sapiens	Q96DD7	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	TSPAN33	Q86UF1	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Complementation	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GAD2	Homo sapiens	Q05329	Y2H Array	32296183
Intra	TSPAN33	Q86UF1	GAD2	Homo sapiens	Q05329	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	TSPAN33	Q86UF1	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15169	TSPAN33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TSPAN33	VGNC	VGNC:66633
Canis familiaris	TSPAN33	VGNC	VGNC:47922
Macaca mulatta	TSPAN33	VGNC	VGNC:79739
Bos taurus	TSPAN33	VGNC	VGNC:36438
Mus musculus	TSPAN33	MGD	MGI:1919012
Rattus norvegicus	TSPAN33	RGD	RGD:1560915

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