IL10RA - interleukin 10 receptor subunit alpha Gene

Homo sapiens

Also known as CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

Gene ID: 3587 | Gene type: protein coding

About IL10RA

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,986,394-118,003,037 (from NCBI)

This gene has 12 transcripts (splice variants), 240 orthologues, 11 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues.

Summary

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the Insulin Receptor substrate-2/PI 3-kinase/Akt pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and Tyk2 kinases. Two transcript variants, one protein-coding and the Other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

IL10RA Products(1)

mRNA	Protein	Name
NM_001558.4	NP_001549.2	interleukin-10 receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-10 receptor activity	IDA IDA: Inferred from direct assay	16982608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11485736	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	16982608	GOA
involved in intestinal epithelial structure maintenance	IDA IDA: Inferred from direct assay	29454749	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	26962683	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	24367025	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	16982608	GOA
involved in ubiquitin-dependent endocytosis	IDA IDA: Inferred from direct assay	22087322	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	22087322	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22087322	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL10RA Protein Structure

Tissue_fac

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

interleukin-10 receptor subunit alpha

IL-10 receptor subunit alpha

IL10RA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL10RA	Q13651	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	ITC	15837194
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	SPR	15837194
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	SPR	12513909
Intra	IL10RA	Q13651	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	IL10RA	Q13651	C1QL4	Homo sapiens	Q86Z23	Validated Y2H	32296183
Intra	IL10RA	Q13651	CD302	Homo sapiens	Q8IX05	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMUB2	Homo sapiens	Q71RG4	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	IL10RA	Q13651	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	22087322
Intra	IL10RA	Q13651	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC66A2	Homo sapiens	Q8N2U9	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	IL10RA	Q13651	HACD2	Homo sapiens	Q6Y1H2	Validated Y2H	32296183
Intra	IL10RA	Q13651	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	IL10RA	Q13651	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	IL10RA	Q13651	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	IL10RA	Q13651	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	IL10RA	Q13651	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Cross	IL10RA	Q13651	UL111A	Human cytomegalovirus	P17150	X-Ray Diffraction	12093920
Cross	IL10RA	Q13651	UL111A	Human cytomegalovirus	P17150	SPR	15837194
Cross	IL10RA	Q13651	NS	Influenza A virus	P03495	Y2H	24008843

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL10RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70692	IL-10R alpha Protein, Human (HEK293, His)	Q13651 (H22-N235)	≥95%
HY-P78464	IL-10R alpha Protein, Human (HEK293, His-Avi)	Q13651 (H22-N235)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 28, Autosomal Recessive

IBD28	Inflammatory Bowel Disease 28, Early Onset, Autosomal Recessive
Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive	Early-Onset Autosomal Recessive Inflammatory Bowel Disease
Bowel Disease, Inflammatory, Type 28, Autosomal Recessive

Inflammatory Bowel Disease 28

Early Onset Autosomal Recessive Inflammatory Bowel Disease 28	Ibd28
Inflammatory Bowel Disease 28, Autosomal Recessive

Inflammatory Bowel Disease 25, Autosomal Recessive

Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome	IBD25
Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive	Il10-Related Early-Onset Ibd
Il10-Related Early-Onset Inflammatory Bowel Disease	Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive
Autosomal Recessive Early-Onset Inflammatory Bowel Disease	Autosomal Recessive Early-Onset Ibd
Early-Onset Autosomal Recessive Inflammatory Bowel Disease	Bowel Disease, Inflammatory, Type 25, Autosomal Recessive

Cytomegalovirus Retinitis

Cmv Retinitis

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome	Fipa
Gastrointestinal Defects And Immunodeficiency Syndrome	Multiple Gastrointestinal Atresias
Familial Isolated Pituitary Adenoma	Intestinal Atresia, Multiple
Multiple Intestinal Atresia	GIDID1
Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Minat
Gidid	Meddra:10028210
Familial Isolated Pituitary Adenoma Syndrome	Intestinal Atresia Multiple
Combined Immunodeficiency-Enteropathy Spectrum	Cid-Mia/Early-Onset Ibd
Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Mia
Gastrointestinal Defect And Immunodeficiency Syndrome	Pituitary Adenoma Predisposition
Pituitary Adenoma, Familial Isolated

Folliculitis

Lymphoproliferative Syndrome, X-Linked, 2

XLP2	Xiap Deficiency
X-Linked Lymphoproliferative Syndrome 2	X-Linked Lymphoproliferative Disease Due To Xiap Deficiency
Xiap-Related Lymphoproliferative Disease, X-Linked	X-Linked Lymphoproliferative Syndrome Type 2
Xiap Deficiency Syndrome

Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked

IPEX	X-Linked Autoimmunity-Allergic Dysregulation Syndrome
Xlaad	Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked
Ipex Syndrome	Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome
Iddm-Secretory Diarrhea Syndrome	Dmsd
Autoimmunity-Immunodeficiency Syndrome, X-Linked	Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy
Xpid	Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked
Autoimmune Enteropathy Type 1	Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked
Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly	Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome
Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked	Autoimmunity-Immunodeficiency Syndrome X-Linked
Iddm Secretory Diarrhea Syndrome	Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome	Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome
X-Linked Autoimmunity-Immunodeficiency Syndrome	Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome
X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Anal Fistula

Anorectal Fistula	Rectal Fistula
Allingham Ulcer	Perianal Fistula
Fistula In Ano	Anorectum Fistula

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06673	IL10RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990776	Vimekofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL10RA	MGD	MGI:96538
Canis familiaris	IL10RA	VGNC	VGNC:41929
Macaca mulatta	IL10RA	VGNC	VGNC:73705
Felis catus	IL10RA	VGNC	VGNC:67753
Bos taurus	IL10RA	VGNC	VGNC:30107
Rattus norvegicus	IL10RA	RGD	RGD:620138
Macaca fascicularis	IL10RA	NCBI	NCBI:102127536
Others	IL10RA	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.