Sirt2 - sirtuin 2 Gene

Rattus norvegicus

Gene ID: 361532 | Gene type: protein coding

About Sirt2

Primary_assembly 1: 84,052,903-84,076,975 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 274.8), Muscle (RPKM 27.6) and 9 other tissues.

Summary

Enables NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including nervous system development; regulation of nervous system development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and non-alcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 Products(2)

mRNA	Protein	Name
NM_001399631.1	NP_001386560.1	NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001399630.1	NP_001386559.1	NAD-dependent protein deacetylase sirtuin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	17344398	RGD
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	17344398	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	21949390	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23522375	RGD
involved in negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17344398	RGD
involved in negative regulation of oligodendrocyte progenitor proliferation	IMP IMP: Inferred from mutant phenotype	17344398	RGD
involved in protein deacetylation	IMP IMP: Inferred from mutant phenotype	21949390	RGD
involved in regulation of myelination	IMP IMP: Inferred from mutant phenotype	21949390	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	28793258	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	28793258	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	28793258	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	28793258	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	27664298	RGD
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	17344398	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	21949390	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	17344398	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	28793258	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28793258	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28793258	RGD
located in heterochromatin	IDA IDA: Inferred from direct assay	17344398	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	17344398	RGD
located in lateral loop	IDA IDA: Inferred from direct assay	21949390	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17344398	RGD
located in myelin sheath abaxonal region	IDA IDA: Inferred from direct assay	17344398	RGD
located in paranodal junction	IDA IDA: Inferred from direct assay	17344398	RGD
located in paranode region of axon	IDA IDA: Inferred from direct assay	17344398	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17344398	RGD
located in terminal loop	IDA IDA: Inferred from direct assay	17344398	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt2 Protein Structure

SIRT1

0
100
200
300
400
489 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-2

5E5 antigen	NAD-dependent deacetylase sirtuin-2
NAD-dependent protein defatty-acylase sirtuin-2	SIR2-like protein 2
regulatory protein SIR2 homolog 2

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0150	Nicotinamide	Inhibitor	99.99%	Unkown
HY-B0879A	Suramin sodium salt	Inhibitor	99.48%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown
HY-B0150A	Nicotinamide Hydrochloride	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10532	SRT 1720	Activator	99.90%	Unkown
HY-107454	OSS_128167	Inhibitor	98.63%	Unkown
HY-100578	AGK2	Inhibitor	99.62%	Unkown
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	Unkown
HY-13515	Sirtinol	Inhibitor	≥98.0%	Unkown
HY-101278	Thiomyristoyl	Inhibitor	99.74%	Unkown
HY-100591	SirReal2	Inhibitor	≥99.0%	Unkown
HY-100732	Cambinol	Inhibitor	99.89%	Unkown
HY-16691	AK-7	Inhibitor	99.63%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.33%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.19%	Unkown
HY-101073	Salermide	Inhibitor	≥98.0%	Unkown
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	98.71%	Unkown
HY-146689	SIRT1-IN-2	Inhibitor	98.86%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-B0150R	Nicotinamide (Standard)	Inhibitor	99.85%	Unkown
HY-101465	AK-1	Inhibitor	99.97%	Unkown
HY-107660	SIRT2-IN-8	Inhibitor	99.32%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-112427	Sirt2-IN-1	Inhibitor	98.71%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.58%	Unkown
HY-146690	SIRT1-IN-3	Inhibitor	99.18%	Unkown
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	Unkown
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-147233	MIND4-19	Inhibitor	99.93%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-111329	JGB1741	Inhibitor	99.05%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-118343	AC-93253	Inhibitor	/	Unkown
HY-149637	HSP70/SIRT2-IN-1	Inhibitor	/	Unkown
HY-W841840	SR94	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-170402	SIRT6-IN-4	Inhibitor	/	Unkown
HY-115979	Sirt2-IN-5	Inhibitor	/	Unkown
HY-163532	FLS-359	Modulator	/	Unkown
HY-114906	SIRT1/2/3-IN-2	Inhibitor	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-145958	Sirt2-IN-6	Inhibitor	/	Unkown
HY-123653	SirReal-1	Inhibitor	/	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-119889	A1B11	Inhibitor	/	Unkown
HY-117442	A2B57	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt2	NCBI	NCBI:22933

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