2. Gene
  3. VWC2 - von Willebrand factor C domain containing 2 Gene

VWC2 - von Willebrand factor C domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNQ739; PSST739

Gene ID: 375567 | Gene type: protein coding

About VWC2

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:49,773,638-49,922,205 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 19 paralogues. Biased expression in heart (RPKM 2.5), ovary (RPKM 2.4) and 3 other tissues.

Summary

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

VWC2 Products(1)

mRNA Protein Name
NM_198570.5 NP_940972.2 brorin precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VWC2 Protein Structure

VWC

VWC: von Willebrand factor type C domain (218 - 273)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

brorin

brain-specific chordin-like protein

VWC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VWC2 Q2TAL6 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
VWC2 Q2TAL6 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 KRTAP13-3 Homo sapiens Q3SY46
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP13-3 Homo sapiens Q3SY46
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 KRTAP13-3 Homo sapiens Q3SY46
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE3E Homo sapiens Q5T5B0
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE4A Homo sapiens Q5TA78
Y2H Array
32296183
Intra
VWC2 Q2TAL6 LCE4A Homo sapiens Q5TA78
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 VASN Homo sapiens Q6EMK4
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
VWC2 Q2TAL6 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ZNF497 Homo sapiens Q6ZNH5
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ZNF696 Homo sapiens Q9H7X3
Anti Tag CoIP
33961781
Intra
VWC2 Q2TAL6 ZNF696 Homo sapiens Q9H7X3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 SHFL Homo sapiens Q9NUL5-4
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 HAPLN2 Homo sapiens Q9GZV7
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE1F Homo sapiens Q5T754
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE1A Homo sapiens Q5T7P2
Y2H Array
32296183
Intra
VWC2 Q2TAL6 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
VWC2 Q2TAL6 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 NTM Homo sapiens Q9P121-3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 LCE1C Homo sapiens Q5T751
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 POU4F2 Homo sapiens Q12837
Y2H Array
32296183
Intra
VWC2 Q2TAL6 POU4F2 Homo sapiens Q12837
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 CRY2 Homo sapiens Q49AN0
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ABHD15 Homo sapiens Q6UXT9
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
VWC2 Q2TAL6 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 LCE3D Homo sapiens Q9BYE3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 TRAPPC14 Homo sapiens Q8WVR3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 TRAPPC14 Homo sapiens Q8WVR3
Y2H Array
32296183
Intra
VWC2 Q2TAL6 TRAPPC14 Homo sapiens Q8WVR3
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 OTX1 Homo sapiens P32242
Y2H Array
32296183
Intra
VWC2 Q2TAL6 OTX1 Homo sapiens P32242
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
VWC2 Q2TAL6 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 FBXW5 Homo sapiens Q969U6
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
VWC2 Q2TAL6 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 FUCA2 Homo sapiens Q9BTY2
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 FUCA2 Homo sapiens Q9BTY2
Y2H Prey Pooling
32296183
Intra
VWC2 Q2TAL6 FUCA2 Homo sapiens Q9BTY2
Y2H Array
32296183
Intra
VWC2 Q2TAL6 LCE3A Homo sapiens Q5TA76
Validated Y2H
32296183
Intra
VWC2 Q2TAL6 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VWC2 Proteins

Cat. No. Product Name Accession Purity
HY-P77506 Brorin/VWC2 Protein, Human (HEK293, His) Q2TAL6 (S28-M325) ≥95%

Related Diseases

Diseases Alias
Tarsal-Carpal Coalition Syndrome

TCC

Tarsal Carpal Coalition Syndrome

Nog-Related-Symphalangism Spectrum Disorder
Craniodiaphyseal Dysplasia

CDD

Schaefer Stein Oshman Syndrome

Craniodiaphyseal Dysplasia, Dominant

Dominantly Inherited Craniodiaphyseal Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15732 VWC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VWC2 MGD MGI:2442987
Canis familiaris VWC2 VGNC VGNC:52060
Rattus norvegicus VWC2 RGD RGD:1589624
Felis catus VWC2 VGNC VGNC:102729
Bos taurus VWC2 VGNC VGNC:36857
Macaca mulatta VWC2 VGNC VGNC:108452
Others VWC2 NCBI