2. Gene
  3. CNNM3 - cyclin and CBS domain divalent metal cation transport mediator 3 Gene

CNNM3 - cyclin and CBS domain divalent metal cation transport mediator 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACDP3

Gene ID: 26505 | Gene type: protein coding

About CNNM3

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,816,268-96,837,466 (from NCBI)

This gene has 5 transcripts (splice variants), 168 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 7.6), small intestine (RPKM 6.3) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in ion transport; magnesium ion homeostasis; and transmembrane transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

CNNM3 Products(2)

mRNA Protein Name
NM_017623.5 NP_060093.3 metal transporter CNNM3 isoform 1 precursor
NM_199078.3 NP_951060.1 metal transporter CNNM3 isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNNM3 Protein Structure

DUF21

DUF21: Domain of unknown function DUF21 (137 - 288)

CBS

CBS: CBS domain (386 - 444)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
Protein Preferred Names Protein Names

metal transporter CNNM3

ancient conserved domain protein 3

CNNM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CNNM3 Q8NE01 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra CNNM3 Q8NE01 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra CNNM3 Q8NE01 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra CNNM3 Q8NE01 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra CNNM3 Q8NE01 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra CNNM3 Q8NE01 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra CNNM3 Q8NE01 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra CNNM3 Q8NE01 PNMA3 Homo sapiens Q9UL41
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 PNMA3 Homo sapiens Q9UL41
Validated Y2H
32296183
Intra CNNM3 Q8NE01 PNMA3 Homo sapiens Q9UL41
Y2H Array
32296183
Intra CNNM3 Q8NE01 PM20D2 Homo sapiens Q8IYS1
Y2H Array
32296183
Intra CNNM3 Q8NE01 PM20D2 Homo sapiens Q8IYS1
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra CNNM3 Q8NE01 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra CNNM3 Q8NE01 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra CNNM3 Q8NE01 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra CNNM3 Q8NE01 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra CNNM3 Q8NE01 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra CNNM3 Q8NE01 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra CNNM3 Q8NE01 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra CNNM3 Q8NE01 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra CNNM3 Q8NE01 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra CNNM3 Q8NE01 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 PNMA2 Homo sapiens Q9UL42
Validated Y2H
32296183
Intra CNNM3 Q8NE01 PNMA2 Homo sapiens Q9UL42
Y2H Array
32296183
Intra CNNM3 Q8NE01 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra CNNM3 Q8NE01 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra CNNM3 Q8NE01 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra CNNM3 Q8NE01 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra CNNM3 Q8NE01 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 SRSF3 Homo sapiens P84103
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 SRSF3 Homo sapiens P84103
Y2H Array
32296183
Intra CNNM3 Q8NE01 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra CNNM3 Q8NE01 ZNF330 Homo sapiens Q9Y3S2
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 ZNF330 Homo sapiens Q9Y3S2
Y2H Array
32296183
Intra CNNM3 Q8NE01 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra CNNM3 Q8NE01 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra CNNM3 Q8NE01 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra CNNM3 Q8NE01 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra CNNM3 Q8NE01 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra CNNM3 Q8NE01 AGR3 Homo sapiens Q8TD06
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 AGR3 Homo sapiens Q8TD06
Validated Y2H
32296183
Intra CNNM3 Q8NE01 AGR3 Homo sapiens Q8TD06
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra CNNM3 Q8NE01 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra CNNM3 Q8NE01 P4HB Homo sapiens P07237
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 P4HB Homo sapiens P07237
Y2H Array
32296183
Intra CNNM3 Q8NE01 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra CNNM3 Q8NE01 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra CNNM3 Q8NE01 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra CNNM3 Q8NE01 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra CNNM3 Q8NE01 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra CNNM3 Q8NE01 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra CNNM3 Q8NE01 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra CNNM3 Q8NE01 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra CNNM3 Q8NE01 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 MDFI Homo sapiens Q99750
Y2H Array
19060904
Intra CNNM3 Q8NE01 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra CNNM3 Q8NE01 MDFI Homo sapiens Q99750
Y2H Pooling
19060904
Intra CNNM3 Q8NE01 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra CNNM3 Q8NE01 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra CNNM3 Q8NE01 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra CNNM3 Q8NE01 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra CNNM3 Q8NE01 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 RBPMS Homo sapiens Q93062-3
Validated Y2H
32296183
Intra CNNM3 Q8NE01 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra CNNM3 Q8NE01 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra CNNM3 Q8NE01 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Intra CNNM3 Q8NE01 FHL3 Homo sapiens Q13643
Validated Y2H
25416956
Intra CNNM3 Q8NE01 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra CNNM3 Q8NE01 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra CNNM3 Q8NE01 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra CNNM3 Q8NE01 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
32296183
Intra CNNM3 Q8NE01 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra CNNM3 Q8NE01 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 RBMX Homo sapiens P38159
Y2H Array
32296183
Intra CNNM3 Q8NE01 RBMX Homo sapiens P38159
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra CNNM3 Q8NE01 CCNDBP1 Homo sapiens O95273
Y2H Array
25416956
Intra CNNM3 Q8NE01 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 ACTN2 Homo sapiens P35609
Y2H Array
32296183
Intra CNNM3 Q8NE01 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Intra CNNM3 Q8NE01 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra CNNM3 Q8NE01 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra CNNM3 Q8NE01 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra CNNM3 Q8NE01 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra CNNM3 Q8NE01 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra CNNM3 Q8NE01 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Jalili Syndrome

Cone-Rod Dystrophy And Amelogenesis Imperfecta

Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome

Cone-Rod Dystrophy Amelogenesis Imperfecta

Cone-Rod Dystrophy With Amelogenesis Imperfecta

JALIS

Cone Rod Dystrophy Amelogenesis Imperfecta
Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases
Pneumonic Tularemia

Pulmonary Tularemia

Bronchopneumonic Tularemia

Pneumonic Tularaemia
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02897 CNNM3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CNNM3 MGD MGI:2151055
Rattus norvegicus CNNM3 RGD RGD:1307926
Felis catus CNNM3 VGNC VGNC:80071
Bos taurus CNNM3 VGNC VGNC:27512
Canis familiaris CNNM3 VGNC VGNC:39408