LCP2 - lymphocyte cytosolic protein 2 Gene

Homo sapiens

Also known as IMD81; SLP76; SLP-76

Gene ID: 3937 | Gene type: protein coding

About LCP2

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,246,233-170,297,777 (from NCBI)

This gene has 9 transcripts (splice variants), 232 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 53.7), appendix (RPKM 44.7) and 19 other tissues.

Summary

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

LCP2 Products(1)

mRNA	Protein	Name
NM_005565.5	NP_005556.1	lymphocyte cytosolic protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8673706	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	20551903	GOA
involved in positive regulation of protein kinase activity	IEP IEP: Inferred from expression pattern	14624253	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TCR signalosome	IDA IDA: Inferred from direct assay	20551903	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20551903	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	20551903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCP2 Protein Structure

SAM_2

SH2

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

lymphocyte cytosolic protein 2

76 kDa tyrosine phosphoprotein

LCP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Y2H Array	32296183
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Validated Y2H	32296183
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Pull Down	9207119
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	CoIP	10570256
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	CoIP	10671560
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Anti Bait CoIP	20534575
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Pull Down	10671560
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Validated Y2H	25814554
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Y2H Array	25814554
Intra	LCP2	Q13094	MAP4K3	Homo sapiens	Q8IVH8	Anti Bait CoIP	21983831
Intra	LCP2	Q13094	MAP4K3	Homo sapiens	Q8IVH8	Anti Tag CoIP	21983831
Intra	LCP2	Q13094	CD6	Homo sapiens	P30203	Anti Bait CoIP	24584089
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Peptide Array	17235283
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	CoIP	10229072
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	ITC	20562827
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	SLC	31467278
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Complementation	31467278
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Pull Down	15929943
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Solution Sedimentation	20562827
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Pull Down	15929943
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Peptide Array	17235283
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Pull Down	10347175
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Pull Down	8673706
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Anti Tag CoIP	21725281
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	SLCA	12773374
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	X-Ray Diffraction	16511262
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	ITC	12773374
Intra	LCP2	Q13094	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	LCP2	Q13094	NCK2	Homo sapiens	O43639	Anti Tag CoIP	25416956
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	BFG-2H	27107012
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Pull Down	15929943
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H Pooling	16189514
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H	21516116
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Validated Y2H	27107012
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Validated Y2H	25416956
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Anti Bait CoIP	20534575
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	ITC	17235283
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	SPR	17235283
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Array	31515488
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	STAM	Homo sapiens	Q92783	Peptide Array	17235283
Intra	LCP2	Q13094	PLCG1	Homo sapiens	P19174	Pull Down	15929943
Intra	LCP2	Q13094	PLCG1	Homo sapiens	P19174	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	ITK	Homo sapiens	Q08881	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	ITK	Homo sapiens	Q08881	Anti Bait CoIP	10556826
Cross	LCP2	Q13094	PLCG1	Bos taurus	P08487	IF	16467851

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LCP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71320	SLP-76 Protein, Human (His-T7)	Q13094 (M1-P533)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 81

IMD81

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07564	LCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LCP2	VGNC	VGNC:42615
Felis catus	LCP2	VGNC	VGNC:68025
Bos taurus	LCP2	VGNC	VGNC:30818
Rattus norvegicus	LCP2	RGD	RGD:619743
Mus musculus	LCP2	MGD	MGI:1321402
Macaca mulatta	LCP2	VGNC	VGNC:74243
Others	LCP2	NCBI

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