ROS1 - ROS proto-oncogene 1, receptor tyrosine kinase Gene

Homo sapiens

Also known as ROS; MCF3; c-ros-1

Gene ID: 6098 | Gene type: protein coding

About ROS1

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,287,353-117,425,942 (from NCBI)

This gene has 3 transcripts (splice variants), 125 orthologues, 53 paralogues and is associated with 133 phenotypes. Restricted expression toward lung (RPKM 10.3).

Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase Insulin Receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

ROS1 Products(17)

mRNA	Protein	Name
NM_001378891.1	NP_001365820.1	proto-oncogene tyrosine-protein kinase ROS isoform 2 precursor
XM_011536054.3	XP_011534356.1	proto-oncogene tyrosine-protein kinase ROS isoform X8
NM_002944.3	NP_002935.2	proto-oncogene tyrosine-protein kinase ROS isoform 1 precursor
XM_011536058.3	XP_011534360.1	proto-oncogene tyrosine-protein kinase ROS isoform X12
XM_011536056.3	XP_011534358.1	proto-oncogene tyrosine-protein kinase ROS isoform X10
XM_011536049.3	XP_011534351.1	proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_047419232.1	XP_047275188.1	proto-oncogene tyrosine-protein kinase ROS isoform X14
XM_011536050.3	XP_011534352.1	proto-oncogene tyrosine-protein kinase ROS isoform X2
XM_011536053.3	XP_011534355.1	proto-oncogene tyrosine-protein kinase ROS isoform X7
XM_011536055.3	XP_011534357.1	proto-oncogene tyrosine-protein kinase ROS isoform X9
XM_006715548.5	XP_006715611.1	proto-oncogene tyrosine-protein kinase ROS isoform X4
XM_011536057.4	XP_011534359.1	proto-oncogene tyrosine-protein kinase ROS isoform X11
XM_047419231.1	XP_047275187.1	proto-oncogene tyrosine-protein kinase ROS isoform X13
NM_001378902.1	NP_001365831.1	proto-oncogene tyrosine-protein kinase ROS isoform 3 precursor
XM_017011173.2	XP_016866662.1	proto-oncogene tyrosine-protein kinase ROS isoform X6
XM_011536051.3	XP_011534353.1	proto-oncogene tyrosine-protein kinase ROS isoform X3
XM_017011172.2	XP_016866661.1	proto-oncogene tyrosine-protein kinase ROS isoform X5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17416557	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16885344	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	16885344	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16885344	GOA
involved in regulation of TOR signaling	IDA IDA: Inferred from direct assay	16885344	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	16885344	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROS1 Protein Structure

fn3

Pkinase_Tyr

0
400
800
1200
1600
2000
2347 a.a.

Protein Preferred Names

Protein Names

proto-oncogene tyrosine-protein kinase ROS

ROS proto-oncogene 1 , receptor tyrosine kinase	c-ros oncogene 1 , receptor tyrosine kinase
proto-oncogene c-Ros-1	transmembrane tyrosine-specific protein kinase
v-ros avian UR2 sarcoma virus oncogene homolog 1

ROS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ROS1	P08922	PTPN6	Homo sapiens	P29350	Phosphatase Assay	17416557
Intra	ROS1	P08922	PTPN1	Homo sapiens	P18031	Phosphatase Assay	17416557

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Childhood Angiosarcoma

Paediatric Angiosarcoma	Paediatric Hemangiosarcoma
Pediatric Angiosarcoma	Pediatric Hemangiosarcoma

Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung	Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Combined Large Cell Lung Neuroendocrine Carcinoma

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Malignant Giant Cell Tumor Of The Tendon Sheath

Giant Cell Tumour Of Tendon Sheath, Malignant

Malignant Giant Cell Neoplasm Of The Tendon Sheath

Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma	Mucin-Secreting Adenocarcinoma
Mucin-Secreting Carcinoma	Mucous Carcinoma
Pseudomyxoma Peritonei With Unknown Primary Site	Adenocarcinoma, Mucinous

Pleomorphic Carcinoma

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Lung Sarcomatoid Carcinoma

Pulmonary Sarcomatoid Carcinoma

Sarcomatoid Carcinoma Of The Lung

Mucinous Lung Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Solid Adenocarcinoma With Mucin Production

Large Cell Neuroendocrine Carcinoma

Thyroid Gland Hurthle Cell Carcinoma

Oncocytic Carcinoma Of The Thyroid

Thyroid Cancer, Hurthle Cell

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To	Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma	Chlc
Chlc, Susceptibility To	Cc
Cholangiocarcinoma Of Biliary Tract	Cholangiocellular Carcinoma
Distal Cholangiocarcinoma	Perihilar Cholangiocarcinoma
Bile Duct Cancer	Cca
Adult Primary Cholangiocellular Carcinoma	Bile Duct Carcinoma

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Lung Large Cell Carcinoma

Large Cell Carcinoma Of Lung	Large Cell Lung Carcinoma
Large Cell Lung Cancer

Adenosquamous Carcinoma

Adenosquamous Cell Carcinoma	Mixed Adenocarcinoma And Squamous Carcinoma
Carcinoma Adenosquamous	Carcinoma, Adenosquamous

Spinal Cord Melanoma

Melanoma Of The Spinal Cord

Childhood Fibrosarcoma

Pediatric Fibrosarcoma

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Congenital Mesoblastic Nephroma

Nephroma, Mesoblastic

Mesoblastic Nephroma

Spitzoid Melanoma

Atypical Spitz Nevus

Pulmonary Plasma Cell Granuloma

Plasma Cell Granuloma, Pulmonary	Granuloma, Plasma Cell, Pulmonary
Lymphocytic Pseudotumor Of Lung	Sclerosing Hemangiocytoma Of Lung

Angiosarcoma

Hemangiosarcoma

Trichothiodystrophy 4, Nonphotosensitive

Amish Brittle Hair Brain Syndrome	TTD4
Trichothiodystrophy, Nonphotosensitive 1	Hair-Brain Syndrome
Bids Syndrome	Ttdn1
Abhs	Pollitt Syndrome
Trichothiodystrophy-Neurocutaneous Syndrome	Nonphotosensitive Trichothiodystrophy 4
Trichorrhexis Nodosa Syndrome	Trichothiodystrophy 4, Non-Photosensitive
Trichothiodystrophy Non-Photosensitive 1

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lymphangitis

Inflammation Of Lymphatics

Fasciitis

Gastric Cancer

Stomach Cancer	Stomach Carcinoma
Gastric Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Mammary Analogue Secretory Carcinoma

Lung Non-Squamous Non-Small Cell Carcinoma

Non- Squamous Nsclc

Adenocarcinoma In Situ

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Main Bronchus Cancer

Malignant Neoplasm Of Main Bronchus

Ca Main Bronchus

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50878	Crizotinib		99.97%	Yes
HY-12215	Lorlatinib		99.92%	Yes
HY-12678	Entrectinib		99.79%	Yes
HY-W015913	Sodium 2-oxopropanoate	Inhibitor	99.86%	Yes
HY-103022	Repotrectinib	Inhibitor	99.90%	Unkown
HY-50878A	Crizotinib hydrochloride		99.86%	Yes
HY-145574	Iruplinalkib	Inhibitor	99.29%	Unkown
HY-12215R	Lorlatinib (Standard)		/	Unkown
HY-50878B	Crizotinib acetate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-152292	Zidesamtinib	Inhibitor	99.55%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2
HY-155163	APG-2449	Inhibitor	98.93%	Phase 1

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0578	Apigenin 7-glucoside		98.98%	Unkown
HY-W015913S	Sodium 2-oxopropanoate-13C3	Inhibitor	99.7%	Unkown
HY-B1106	Tetrahydroxyquinone		≥98.0%	Unkown
HY-B1106A	Tetrahydroxyquinone monohydrate	Activator	≥97.0%	Unkown
HY-112801	F-1	Inhibitor	98.03%	Unkown
HY-122311	Orniplabin	Inhibitor	/	Unkown
HY-N7798	Pennogenin		99.90%	Unkown
HY-N1306	Sideroxylin		/	Unkown
HY-W015913R	Sodium 2-oxopropanoate (standard)	Inhibitor	/	Unkown
HY-161358	FAK-IN-20		/	Unkown
HY-111416	WY-135	Inhibitor	/	Unkown
HY-135509	Lorlatinib acetate		/	Unkown
HY-159147	SIAIS039		/	Unkown
HY-117420	CM764	Activator	/	Unkown
HY-120387	SMU-B	Inhibitor	/	Unkown
HY-123454	SKF1		/	Unkown
HY-130794	ALK/ROS1-IN-1	Inhibitor	/	Unkown
HY-144697	p38 MAPK-IN-3		/	Unkown
HY-147795	Nampt-IN-8		/	Unkown
HY-150974	ROS1-IN-1	Inhibitor	/	Unkown
HY-153743	Protein kinase inhibitor 4	Inhibitor	/	Unkown
HY-155178	Antiproliferative agent-34	Inhibitor	/	Unkown
HY-156360	Xanthine oxidase-IN-12	Inhibitor	/	Unkown
HY-157391	ALK/ROS1-IN-3	Inhibitor	/	Unkown
HY-157437	AChE/BChE-IN-16	Inhibitor	/	Unkown
HY-158016	Antiproliferative agent-49		/	Unkown
HY-161966	VEGFR-2-IN-52		/	Unkown
HY-161975	ROS1-IN-2	Inhibitor	/	Unkown
HY-162311	Anticancer agent 194		/	Unkown
HY-162488	Laccase-IN-3	Inhibitor	/	Unkown
HY-163862	PPARα agonist 3		/	Unkown
HY-N11887	Linocinnamarin	Inhibitor	/	Unkown
HY-N2693	6,8-Diprenylorobol		/	Unkown
HY-RS12135	ROS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12136	Ros1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12137	ROS1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160172	ALK/ROS1-IN-4	Inhibitor	/	Unkown
HY-160172A	ALK/ROS1-IN-4 hydrate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ROS1	VGNC	VGNC:34091
Canis familiaris	ROS1	VGNC	VGNC:45698
Rattus norvegicus	ROS1	RGD	RGD:3591
Felis catus	ROS1	VGNC	VGNC:64724
Mus musculus	ROS1	MGD	MGI:97999
Others	ROS1	NCBI