Nampt - nicotinamide phosphoribosyltransferase Gene

Mus musculus

Also known as Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik

Gene ID: 59027 | Gene type: protein coding

About Nampt

Chromosome 12: 32,869,544-32,903,348 forward strand.GRCm39:CM001005.3

This gene has 3 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 15 phenotypes. Ubiquitous expression in heart adult (RPKM 19.2), bladder adult (RPKM 15.4) and 28 other tissues.

Summary

Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression. Acts upstream of or within NAD biosynthetic process and circadian rhythm. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt Products(1)

mRNA	Protein	Name
NM_021524.2	NP_067499.2	nicotinamide phosphoribosyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16783373	MGI
enables nicotinamide phosphoribosyltransferase activity	IDA IDA: Inferred from direct assay	15381699	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within NAD biosynthetic process	IDA IDA: Inferred from direct assay	15381699	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19299583	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19299583	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15381699	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nampt Protein Structure

PBEF_like

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

nicotinamide phosphoribosyltransferase

pre-B-cell colony-enhancing factor 1 homolog

Nampt Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nampt	Q99KQ4	Nampt	Mus musculus	Q99KQ4	X-Ray Diffraction	16783377
Intra	Nampt	Q99KQ4	Nampt	Mus musculus	Q99KQ4	GMS	16783377
Intra	Nampt	Q99KQ4	Nampt	Mus musculus	Q99KQ4	Light Scattering	16783377
Intra	Nampt	Q99KQ4	Nampt	Mus musculus	Q99KQ4	X-Ray Diffraction	16783373

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50876	Daporinad	Inhibitor	99.91%	Phase 2
HY-12793	Padnarsertib	Inhibitor	99.86%	Phase 2
HY-10079	CHS-828	Inhibitor	99.28%	Phase 1
HY-136241	OT-82	Inhibitor	99.84%	Phase 1
HY-10080	Teglarinad chloride	Inhibitor	98.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (48)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126255	SBI-797812	Activator	99.74%	Unkown
HY-144776	NAT	Activator	99.85%	Unkown
HY-15766	GNE-617	Inhibitor	99.58%	Unkown
HY-12971	Nampt-IN-1	Inhibitor	99.48%	Unkown
HY-12808	STF-118804	Inhibitor	99.72%	Unkown
HY-152154	Nampt degrader-2	Inhibitor	99.41%	Unkown
HY-12628	GNE-618	Inhibitor	99.89%	Unkown
HY-148815	Nampt activator-1	Activator	98.42%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	99.35%	Unkown
HY-148822	Nampt activator-2	Activator	98.80%	Unkown
HY-161515	BRD4/NAMPT-IN-1	Inhibitor	99.45%	Unkown
HY-148948	Nampt activator-3	Activator	99.67%	Unkown
HY-147193	Nampt-IN-10 TFA	Inhibitor	98.70%	Unkown
HY-14373	CB30865	Inhibitor	98.75%	Unkown
HY-130606	Nampt-IN-5	Inhibitor	98.02%	Unkown
HY-402237	Nampt-IN-15	Inhibitor	99.49%	Unkown
HY-14374	GPP78	Inhibitor	≥99.0%	Unkown
HY-15766A	GNE-617 hydrochloride	Inhibitor	99.16%	Unkown
HY-162537	LYP-8	Inhibitor	/	Unkown
HY-108701	Nampt-IN-3	Inhibitor	98.97%	Unkown
HY-101280	LB-60-OF61	Inhibitor	99.25%	Unkown
HY-14375	CB 300919	Inhibitor	98.01%	Unkown
HY-101280A	LB-60-OF61 hydrochloride	Inhibitor	/	Unkown
HY-159009	MS7	Inhibitor	/	Unkown
HY-147838	Nampt-IN-9	Inhibitor	/	Unkown
HY-162124	HDAC/NAMPT-IN-1	Inhibitor	/	Unkown
HY-163445	NAMPT activator-6	Activator	/	Unkown
HY-147656	NAMPT degrader-1	Inhibitor	/	Unkown
HY-163440	PROTAC NAMPT Degrader-1	Degrader	/	Unkown
HY-161712	Nampt-IN-12	Inhibitor	99.76%	Unkown
HY-147756	Nampt-IN-7	Inhibitor	/	Unkown
HY-163500	NAMPT activator-8	Activator	/	Unkown
HY-163280	JGB-1-155	Activator	/	Unkown
HY-161051	Anticancer agent 177	Inhibitor	/	Unkown
HY-162519	LZFPN-90	Inhibitor	/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-163499	NAMPT activator-7	Activator	/	Unkown
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-158319	Mutant IDH1/NAMPT-IN-1	Inhibitor	/	Unkown
HY-157421	Nampt activator-4	Modulator	/	Unkown
HY-147795	Nampt-IN-8	Inhibitor	/	Unkown
HY-164759	Nampt-IN-13	Inhibitor	/	Unkown
HY-110319	(E/Z)-Daporinad hydrochloride	Inhibitor	/	Unkown
HY-148572	NAMPT/IDO1-IN-1	Inhibitor	/	Unkown
HY-147193A	Nampt-IN-10 trihydrochloride	Inhibitor	/	Unkown
HY-161180	Antitumor agent-136	Inhibitor	/	Unkown
HY-10079A	CHS-828 (nicotinate)	Inhibitor	/	Unkown
HY-125147	A-1293201	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991075	ALT-100 (Human IgG1)	Inhibitor	/	Unkown
HY-P990319	ALT-100 (Human IgG4)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nampt	NCBI	NCBI:10135

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