2. Gene
  3. DDX39B - DExD-box helicase 39B Gene

DDX39B - DExD-box helicase 39B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BAT1; UAP56; D6S81E

Gene ID: 7919 | Gene type: protein coding

About DDX39B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,530,226-31,542,003 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 153 orthologues and 38 paralogues. Ubiquitous expression in endometrium (RPKM 76.9), ovary (RPKM 76.7) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

DDX39B Products(2)

mRNA Protein Name
NM_004640.7 NP_004631.1 spliceosome RNA helicase DDX39B
NM_080598.6 NP_542165.1 spliceosome RNA helicase DDX39B

DDX39B Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (70 - 235)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (306 - 382)

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  • 428 a.a.
Protein Preferred Names Protein Names

spliceosome RNA helicase DDX39B

56 kDa U2AF65-associated protein

DDX39B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DDX39B Q13838 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
DDX39B Q13838 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
DDX39B Q13838 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
DDX39B Q13838 LUZP4 Homo sapiens Q9P127
Y2H Array
32296183
Intra
DDX39B Q13838 LUZP4 Homo sapiens Q9P127
Y2H Prey Pooling
32296183
Intra
DDX39B Q13838 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
DDX39B Q13838 API5 Homo sapiens Q9BZZ5
Anti Tag CoIP
35271311
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Prey Pooling
32296183
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2-3
Validated Y2H
32296183
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Array
32296183
Intra
DDX39B Q13838 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
DDX39B Q13838 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
DDX39B Q13838 SARNP Homo sapiens P82979
Y2H
14667819
Intra
DDX39B Q13838 SARNP Homo sapiens P82979
Anti Tag CoIP
35271311
Intra
DDX39B Q13838 ALYREF Homo sapiens Q86V81
Anti Tag CoIP
35271311
Intra
DDX39B Q13838 ALYREF Homo sapiens Q86V81
Y2H
14667819
Intra
DDX39B Q13838 ALYREF Homo sapiens Q86V81
Pull Down
11979277
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2
Y2H
14667819
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2
Crosslink
30021884
Intra
DDX39B Q13838 CHTOP Homo sapiens Q9Y3Y2
Pull Down
23299939
Intra
DDX39B Q13838 DDX39A Homo sapiens O00148
Y2H
14667819
Intra
DDX39B Q13838 THOC1 Homo sapiens Q96FV9
Anti Tag CoIP
35271311
Intra
DDX39B Q13838 THOC1 Homo sapiens Q96FV9
Pull Down
11979277
Intra
DDX39B Q13838 SNRPA Homo sapiens P09012
Y2H Array
32296183
Intra
DDX39B Q13838 SNRPA Homo sapiens P09012
Y2H Prey Pooling
32296183
Intra
DDX39B Q13838 FYTTD1 Homo sapiens Q96QD9
Anti Bait CoIP
21814512
Intra
DDX39B Q13838 FYTTD1 Homo sapiens Q96QD9
Anti Tag CoIP
35271311
Intra
DDX39B Q13838 FYTTD1 Homo sapiens Q96QD9
Pull Down
21814512
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DDX39B Proteins

Cat. No. Product Name Accession Purity
HY-P71534 DDX39B Protein, Human (GST) Q13838 (A2-V251) ≥95%

Related Diseases

Diseases Alias
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome 1

LCCS1

Multiple Contracture Syndrome, Finnish Type

Lccs

Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures

Lethal Congenital Contracture Syndrome Type 1

Herva Disease

Multiple Contracture Syndrome Finnish Type

Contracture Syndrome, Lethal, Congenital, Type 1
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03645 DDX39B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DDX39B VGNC VGNC:71621
Bos taurus DDX39B VGNC VGNC:27965
Felis catus DDX39B VGNC VGNC:61407
Rattus norvegicus DDX39B RGD RGD:70923
Canis familiaris DDX39B VGNC VGNC:39855
Mus musculus DDX39B MGD MGI:99240
Others DDX39B NCBI