MAP1LC3A - microtubule associated protein 1 light chain 3 alpha Gene

Homo sapiens

Also known as LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3

Gene ID: 84557 | Gene type: protein coding

About MAP1LC3A

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,546,844-34,560,345 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 31.2), fat (RPKM 18.3) and 25 other tissues.

Summary

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the Cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple LIGHT chain subunits. The protein encoded by this gene is one of the LIGHT chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

MAP1LC3A Products(2)

mRNA	Protein	Name
NM_032514.4	NP_115903.1	microtubule-associated proteins 1A/1B light chain 3A isoform a
NM_181509.3	NP_852610.1	microtubule-associated proteins 1A/1B light chain 3A isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	15187094	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11096062	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	24290141	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	28223137	GOA
acts upstream of or within autophagy of mitochondrion	IGI IGI: Inferred from genetic interaction	22267086	GOA
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	28223137	GOA
involved in macroautophagy	IDA IDA: Inferred from direct assay	28223137	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autolysosome	IDA IDA: Inferred from direct assay	25327288	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	12740394	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15187094	GOA
located in organelle membrane	IDA IDA: Inferred from direct assay	12740394	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3A Protein Structure

Atg8

0
100
121 a.a.

Protein Preferred Names

Protein Names

microtubule-associated proteins 1A/1B light chain 3A

MAP1 light chain 3-like protein 1

Recombinant MAP1LC3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70916	MAP1LC3A Protein, Human (His)	Q9H492-1 (M1-F121)	≥95%

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8, Formerly	Rp8, Formerly
Retinitis Pigmentosa 21, Formerly	Rp21, Formerly
Usher Syndrome

Alzheimer Disease 13

AD13	Alzheimer Disease-13
Alzheimer'S Disease 13	Alzheimer'S Disease 13, Late Onset

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08028	MAP1LC3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP1LC3A	VGNC	VGNC:68152
Canis familiaris	MAP1LC3A	VGNC	VGNC:54324
Macaca mulatta	MAP1LC3A	VGNC	VGNC:95358
Rattus norvegicus	MAP1LC3A	RGD	RGD:735183
Bos taurus	MAP1LC3A	VGNC	VGNC:31179
Mus musculus	MAP1LC3A	MGD	MGI:1915661
Others	MAP1LC3A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.