2. Gene
  3. MAP1LC3A - microtubule associated protein 1 light chain 3 alpha Gene

MAP1LC3A - microtubule associated protein 1 light chain 3 alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3

Gene ID: 84557 | Gene type: protein coding

About MAP1LC3A

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,546,844-34,560,345 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 31.2), fat (RPKM 18.3) and 25 other tissues.

Summary

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the Cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

MAP1LC3A Products(2)

mRNA Protein Name
NM_032514.4 NP_115903.1 microtubule-associated proteins 1A/1B light chain 3A isoform a
NM_181509.3 NP_852610.1 microtubule-associated proteins 1A/1B light chain 3A isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
15187094 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11096062 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25127057 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
24290141 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
28223137 GOA
acts upstream of or within autophagy of mitochondrion IGI
IGI: Inferred from genetic interaction
22267086 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
28223137 GOA
involved in macroautophagy IDA
IDA: Inferred from direct assay
28223137 GOA
Cellular Component GO Annotation Evidence Reference Source
located in autolysosome IDA
IDA: Inferred from direct assay
25327288 GOA
located in autophagosome IDA
IDA: Inferred from direct assay
12740394 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15187094 GOA
located in organelle membrane IDA
IDA: Inferred from direct assay
12740394 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3A Protein Structure

Atg8

Atg8: Autophagy protein Atg8 ubiquitin like (16 - 120)

  • 0
  • 100
  • 121 a.a.
Protein Preferred Names Protein Names

microtubule-associated proteins 1A/1B light chain 3A

MAP1 light chain 3-like protein 1

MAP1LC3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
29892012
Intra
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Validated Y2H
25416956
Intra
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
25416956
Intra
MAP1LC3A Q9H492 NEK9 Homo sapiens Q8TD19
Phage Display
35044719
Intra
MAP1LC3A Q9H492 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 IRGQ Homo sapiens Q8WZA9
BioID
34524948
Intra
MAP1LC3A Q9H492 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Cross
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
ITC
20010802
Cross
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
NMR
20010802
Cross
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
Pull Down
20010802
Intra
MAP1LC3A Q9H492 KRT1 Homo sapiens P04264
FPS
39009827
Intra
MAP1LC3A Q9H492 KRT1 Homo sapiens P04264
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 FUNDC1 Homo sapiens Q8IVP5
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Phage Display
37219487
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Phage Display
35044719
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
FPS
37219487
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Pull Down
23459205
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 TBK1 Homo sapiens Q9UHD2
FPS
37219487
Intra
MAP1LC3A Q9H492 TBK1 Homo sapiens Q9UHD2
ITC
37219487
Intra
MAP1LC3A Q9H492 IRS4 Homo sapiens O14654
Phage Display
35044719
Intra
MAP1LC3A Q9H492 IRS4 Homo sapiens O14654
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
Intra
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra
MAP1LC3A Q9H492 UBQLN4 Homo sapiens Q9NRR5
Confocal
23459205
Intra
MAP1LC3A Q9H492 UBQLN4 Homo sapiens Q9NRR5
Pull Down
23459205
Intra
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Anti Tag CoIP
20562859
Intra
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Validated Y2H
32296183
Intra
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Validated Y2H
25416956
Intra
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Array
32296183
Intra
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
25416956
Intra
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
Pull Down
19250911
Intra
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
IF
19427866
Intra
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
Pull Down
19427866
Intra
MAP1LC3A Q9H492 TOLLIP Homo sapiens Q9H0E2
Anti Tag CoIP
25042851
Intra
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Y2H Prey Pooling
32296183
Intra
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Validated Y2H
32296183
Intra
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP1LC3A Proteins

Cat. No. Product Name Accession Purity
HY-P70916 MAP1LC3A Protein, Human (His) Q9H492-1 (M1-F121) ≥95%

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8, Formerly

Rp8, Formerly

Retinitis Pigmentosa 21, Formerly

Rp21, Formerly

Usher Syndrome
Alzheimer Disease 13

AD13

Alzheimer Disease-13

Alzheimer'S Disease 13

Alzheimer'S Disease 13, Late Onset
Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08028 MAP1LC3A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP1LC3A VGNC VGNC:68152
Canis familiaris MAP1LC3A VGNC VGNC:54324
Macaca mulatta MAP1LC3A VGNC VGNC:95358
Rattus norvegicus MAP1LC3A RGD RGD:735183
Bos taurus MAP1LC3A VGNC VGNC:31179
Mus musculus MAP1LC3A MGD MGI:1915661
Others MAP1LC3A NCBI