2. Gene
  3. ATG5 - autophagy related 5 Gene

ATG5 - autophagy related 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ASP; APG5; APG5L; hAPG5; SCAR25; APG5-LIKE

Gene ID: 9474 | Gene type: protein coding

About ATG5

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:106,184,476-106,325,760 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 11.9), adrenal (RPKM 11.0) and 25 other tissues.

Summary

The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating Enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate Antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and Apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

ATG5 Products(5)

mRNA Protein Name
NM_001286106.2 NP_001273035.1 autophagy protein 5 isoform a
NM_001286107.2 NP_001273036.1 autophagy protein 5 isoform b precursor
NM_001286108.2 NP_001273037.1 autophagy protein 5 isoform c
NM_001286111.2 NP_001273040.1 autophagy protein 5 isoform d
NM_004849.4 NP_004840.1 autophagy protein 5 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Atg8-family ligase activity IDA
IDA: Inferred from direct assay
23202584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9852036 GOA
Biological Process GO Annotation Evidence Reference Source
involved in aggrephagy IMP
IMP: Inferred from mutant phenotype
22982048 GOA
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
23202584 GOA
involved in autophagy IGI
IGI: Inferred from genetic interaction
28389568 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
26812546 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
25484072 GOA
acts upstream of or within negative regulation of autophagic cell death IMP
IMP: Inferred from mutant phenotype
19273585 GOA
involved in negative regulation of defense response to virus IDA
IDA: Inferred from direct assay
19666601 GOA
involved in positive regulation of viral translation IDA
IDA: Inferred from direct assay
19666601 GOA
involved in regulation of autophagosome maturation IMP
IMP: Inferred from mutant phenotype
22342342 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Atg12-Atg5-Atg16 complex IPI
IPI: Inferred from physical interaction
23202584 GOA
located in autophagosome IDA
IDA: Inferred from direct assay
15292400 GOA
located in membrane IDA
IDA: Inferred from direct assay
23093945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG5 Protein Structure

APG5

APG5: Autophagy protein Apg5 (79 - 271)

  • 0
  • 100
  • 200
  • 275 a.a.
Protein Preferred Names Protein Names

autophagy protein 5

APG5 autophagy 5-like

ATG5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ATG5 Q9H1Y0 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra ATG5 Q9H1Y0 ATG10 Homo sapiens Q9H0Y0
Y2H Array
32296183
Intra ATG5 Q9H1Y0 ATG10 Homo sapiens Q9H0Y0
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra ATG5 Q9H1Y0 FMR1 Homo sapiens Q8IXW7
Y2H Array
32296183
Intra ATG5 Q9H1Y0 FMR1 Homo sapiens Q8IXW7
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra ATG5 Q9H1Y0 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra ATG5 Q9H1Y0 MAVS Homo sapiens Q7Z434-1
Pull Down
17709747
Intra ATG5 Q9H1Y0 MAVS Homo sapiens Q7Z434-1
Anti Tag CoIP
17709747
Intra ATG5 Q9H1Y0 RIGI Homo sapiens O95786-1
Pull Down
17709747
Intra ATG5 Q9H1Y0 RIGI Homo sapiens O95786-1
Anti Tag CoIP
17709747
Intra ATG5 Q9H1Y0 WDFY3 Homo sapiens Q8IZQ1
Anti Tag CoIP
20417604
Intra ATG5 Q9H1Y0 WDFY3 Homo sapiens Q8IZQ1
Confocal
20417604
Intra ATG5 Q9H1Y0 WDFY3 Homo sapiens Q8IZQ1
Y2H
20417604
Intra ATG5 Q9H1Y0 PSMB11 Homo sapiens A5LHX3
Y2H Array
32296183
Intra ATG5 Q9H1Y0 PSMB11 Homo sapiens A5LHX3
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 CCDC12 Homo sapiens Q8WUD4
Anti Tag CoIP
20562859
Intra ATG5 Q9H1Y0 CCDC12 Homo sapiens Q8WUD4
Anti Tag CoIP
33961781
Intra ATG5 Q9H1Y0 CCDC12 Homo sapiens Q8WUD4
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 CCDC12 Homo sapiens Q8WUD4
Y2H Array
32296183
Intra ATG5 Q9H1Y0 TECPR1 Homo sapiens Q7Z6L1
Anti Tag CoIP
20562859
Intra ATG5 Q9H1Y0 TECPR1 Homo sapiens Q7Z6L1
Anti Tag CoIP
33961781
Intra ATG5 Q9H1Y0 TECPR1 Homo sapiens Q7Z6L1
Y2H Array
32296183
Intra ATG5 Q9H1Y0 TECPR1 Homo sapiens Q7Z6L1
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra ATG5 Q9H1Y0 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra ATG5 Q9H1Y0 ATG16L1 Homo sapiens Q676U5
GMS
23202584
Intra ATG5 Q9H1Y0 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
20562859
Intra ATG5 Q9H1Y0 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
33961781
Intra ATG5 Q9H1Y0 ATG16L1 Homo sapiens Q676U5
Ion Exchange Chrom
23202584
Intra ATG5 Q9H1Y0 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra ATG5 Q9H1Y0 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra ATG5 Q9H1Y0 UCHL1 Homo sapiens P09936
Anti Bait CoIP
17353931
Intra ATG5 Q9H1Y0 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
Intra ATG5 Q9H1Y0 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Intra ATG5 Q9H1Y0 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra ATG5 Q9H1Y0 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
32296183
Intra ATG5 Q9H1Y0 TEKT4 Homo sapiens Q8WW24
Y2H Array
31515488
Intra ATG5 Q9H1Y0 TEKT4 Homo sapiens Q8WW24
Y2H Array
32296183
Intra ATG5 Q9H1Y0 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG5 Proteins

Cat. No. Product Name Accession Purity
HY-P7620 ATG5 Protein, Human Q9H1Y0 (M1-D275) ≥95%

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, Autosomal Recessive 25

SCAR25

Autosomal Recessive Spinocerebellar Ataxia 25

Spinocerebellar Ataxia, Autosomal Recessive, 25
Stomatitis
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency

VICIS

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

Dionisi Vici Sabetta Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

Dionisi-Vici-Sabetta-Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33

CILD33

Ciliary Dyskinesia, Primary, 33, Without Situs Inversus

Primary Ciliary Dyskinesia 33 Without Situs Inversus
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Mouth Disease

Mouth Diseases

Mouth Disorders
Danon Disease

Pseudoglycogenosis Ii

Antopol Disease

Glycogen Storage Disease Iib

Glycogen Storage Disease Type 2b

Glycogen Storage Disease Type Iib

Gsd2b

Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency

Vacuolar Cardiomyopathy And Myopathy X-Linked

Vacuolar Cardiomyopathy And Myopathy, X-Linked

Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly

Gsd2b, Formerly

Gsd Iib, Formerly

Glycogen Storage Cardiomyopathy

Glycogen Storage Disease Limited To The Heart

Pseudoglycogenosis 2

X-Linked Vacuolar Cardiomyopathy And Myopathy

Lysosomal Glycogen Storage Disease With Normal Acid Maltase

Glycogen Storage Disease Due To Lamp-2 Deficiency

Gsd Due To Lamp-2 Deficiency

Glycogenosis Due To Lamp-2 Deficiency

Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity

DAND

Gsd-Iib
Cerebellar Hypoplasia
Myopathy, X-Linked, With Excessive Autophagy

X-Linked Myopathy With Excessive Autophagy

Xmea

MEAX

Vacuolar Myopathy
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Malt Worker'S Lung

Alveolitis Due To Aspergillus Clavatus

Malt Worker Lung

Malt Workers' Lung

Malt-Workers' Lung

Malt Fever

Malt House Workers' Cough

Malt-Workers' Alveolitis

Malt-Workers' Lung Disease

Alveolitis Due To Aspergillus Fumigatus

Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14

ARMD14

Macular Degeneration, Age-Related, 14, Reduced Risk Of

Macular Degeneration, Age-Related, Type 14
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W018791 Bifendate 99.91% Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151914 Antitumor agent-82 Inducer / Unkown
HY-157548 Antitumor agent-133 Inducer / Unkown
HY-167843 Alborixin Inhibitor / Unkown
HY-RS01152 ATG5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG5 VGNC VGNC:56361
Macaca mulatta ATG5 VGNC VGNC:70165
Rattus norvegicus ATG5 RGD RGD:1359580
Mus musculus ATG5 MGD MGI:1277186
Canis familiaris ATG5 VGNC VGNC:38226
Felis catus ATG5 VGNC VGNC:67742
Others ATG5 NCBI