2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 17

GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury.

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GSK-3β inhibitor 17 Chemical Structure

GSK-3β inhibitor 17 Chemical Structure

CAS No. : 2521624-67-7

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GSK-3β inhibitor 17 Related Antibodies

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Description

GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury[1].

IC50 & Target[1]

GSK-3β

 

In Vitro

GSK-3β inhibitor 17 (compound 5 n) (16, 32, 64 µM) reduces cisplatin (HY-17394) induced p-p65, KIM-1 protein expression in a dose-dependent manner[1].
GSK-3β inhibitor 17 (32 µM) decreases the TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression levels in cisplatin induces acute kidney injury (AKI) in HK-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-3β inhibitor 17 Related Antibodies

Western Blot Analysis[1]

Cell Line: HK-2 cells
Concentration: 16, 32, 64 µM
Incubation Time:
Result: Decreased the cisplatin (20 µM; 24 h) induced protein expression of p-p65, KIM-1.
In Vivo

GSK-3β inhibitor 17 (12.5, 25, 50 mg/kg; i.p.) reduces cisplatin (HY-17394) induced NF-κB signaling activation and inflammatory cytokine release, thereby reducing kidney injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, 20-22 g, Male C57/BL6 mice (cisplatin 20 mg/kg i.p. for 3 days)[1]
Dosage: 12.5, 25, 50 mg/kg
Administration: I.p.; 24 h before the modeling
Result: Inhibited cisplatin-induced renal glycogen accumulation and tubular necrosis, 5n significantly reduced the protein level of p-P65 in cisplatin treatment, significantly downregulated mRNA levels of TNF-α, IL-1β, IL-6 and MCP-1.
Molecular Weight

617.58

Formula

C26H18F3N5O6S2
CAS No.
SMILES

COC(C1=CC=C(S1)S(=O)(NC2=CC=C(C=C2)C3=NC(C4=CC(NC5=CC=C(C=C5)OC(F)(F)F)=NC=C4)=NO3)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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GSK-3β inhibitor 17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 172521624-67-7GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3cisplatinacute kidney injuryp-p65KIM-1HK-2 cellsanti-inflammationInhibitorinhibitorinhibit

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