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  4. HIV-1 inhibitor-61

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC50 of 0.07 nM in NL4-3 wt MT-4 cells.

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HIV-1 inhibitor-61 Chemical Structure

HIV-1 inhibitor-61 Chemical Structure

CAS No. : 1114507-62-8

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HIV-1 inhibitor-61 Related Antibodies

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Description

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC50 of 0.07 nM in NL4-3 wt MT-4 cells[1].

Cellular Effect
Cell Line Type Value Description References
MT4 EC50
0.0006 μM
Compound: rac-2
Antiviral activity against wild type HIV1 NL4-3 infected in human MT4 cells after 5 days by MTT assay
Antiviral activity against wild type HIV1 NL4-3 infected in human MT4 cells after 5 days by MTT assay
[PMID: 19140683]
MT4 EC50
0.045 μM
Compound: rac-2
Antiviral activity against HIV1 reverse transcriptase Y188L mutant infected in human MT4 cells after 5 days by MTT assay
Antiviral activity against HIV1 reverse transcriptase Y188L mutant infected in human MT4 cells after 5 days by MTT assay
[PMID: 19140683]
MT4 EC50
0.16 μM
Compound: rac-2
Antiviral activity against HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells after 5 days by MTT assay
Antiviral activity against HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells after 5 days by MTT assay
[PMID: 19140683]
MT4 EC50
0.52 μM
Compound: rac-2
Antiviral activity against HIV1 reverse transcriptase K103N mutant infected in human MT4 cells after 5 days by MTT assay
Antiviral activity against HIV1 reverse transcriptase K103N mutant infected in human MT4 cells after 5 days by MTT assay
[PMID: 19140683]
MT4 CC50
37.3 μM
Compound: rac-2
Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
[PMID: 19140683]
TZM CC50
31.1 μM
Compound: 1
Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability after 2 days by WST-1 assay
Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability after 2 days by WST-1 assay
[PMID: 26898379]
Molecular Weight

442.52

Formula

C24H24F2N2O2S
CAS No.
SMILES

O=C1NC(SC[C@H]2[C@H](C3=CC=C(OC)C=C3)C2)=NC([C@@H](C4=C(F)C=CC=C4F)C)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-611114507-62-8HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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HIV-1 inhibitor-61
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HY-10891
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