2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. QX-314 bromide

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.

For research use only. We do not sell to patients.

QX-314 bromide Chemical Structure

QX-314 bromide Chemical Structure

CAS No. : 24003-58-5

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of QX-314 bromide:

QX-314 bromide Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].

IC50 & Target

sodium channel[1]
In Vitro

QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1].
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1].
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1].
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3].
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QX-314 bromide Related Antibodies
In Vivo

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-290 g)[2]
Dosage: 1.6 mg/kg
Administration: Intracutaneous injection
Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
Molecular Weight

343.30

Formula

C16H27BrN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (291.29 mM; Need ultrasonic)

DMSO : 50 mg/mL (145.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9129 mL 14.5645 mL 29.1290 mL
5 mM 0.5826 mL 2.9129 mL 5.8258 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (6.06 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (6.06 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (145.65 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.9129 mL 14.5645 mL 29.1290 mL 72.8226 mL
5 mM 0.5826 mL 2.9129 mL 5.8258 mL 14.5645 mL
10 mM 0.2913 mL 1.4565 mL 2.9129 mL 7.2823 mL
15 mM 0.1942 mL 0.9710 mL 1.9419 mL 4.8548 mL
20 mM 0.1456 mL 0.7282 mL 1.4565 mL 3.6411 mL
25 mM 0.1165 mL 0.5826 mL 1.1652 mL 2.9129 mL
30 mM 0.0971 mL 0.4855 mL 0.9710 mL 2.4274 mL
40 mM 0.0728 mL 0.3641 mL 0.7282 mL 1.8206 mL
50 mM 0.0583 mL 0.2913 mL 0.5826 mL 1.4565 mL
60 mM 0.0485 mL 0.2427 mL 0.4855 mL 1.2137 mL
80 mM 0.0364 mL 0.1821 mL 0.3641 mL 0.9103 mL
100 mM 0.0291 mL 0.1456 mL 0.2913 mL 0.7282 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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QX-314 bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QX-31424003-58-5QX314QX 314Sodium ChannelNa channelsNa+ channelssodiumchannel,calciumchannelInhibitorinhibitorinhibit

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