2. Metabolic Enzyme/Protease Immunology/Inflammation TGF-beta/Smad Stem Cell/Wnt
  3. Endogenous Metabolite MMP Interleukin Related PKA
  4. Rhamnose monohydrate

Rhamnose monohydrate  (Synonyms: L-Rhamnose monohydrate)

Cat. No.: HY-N1420A Purity: ≥98.0%
SDS
COA
Handling Instructions Technical Support

Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.

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Rhamnose monohydrate Chemical Structure

Rhamnose monohydrate Chemical Structure

CAS No. : 10030-85-0

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Rhamnose monohydrate:

Rhamnose monohydrate Related Antibodies

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  • Biological Activity

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Description

Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas[2][3][5].
IC50 & Target

Microbial Metabolite

 

In Vitro

Rhamnose (50 mM, 30 h) monohydrate can regulate the expression of Prha target genes in Listeria monocytogenes[1].
Rhamnose (1 mM) monohydrate can reduce the levels of pro-inflammatory interleukins and matrix metalloproteinases (MMPs) in a human dermal fibroblast (NHDF) skin aging model stimulated by advanced glycation end products (AGEs), thus possessing anti-aging potential[2].
Rhamnose (0-300 μM, 1 h) monohydrate promotes phosphorylation of PKA substrate and HSL in SVF-derived adipocytes, stimulates PKA signaling and induces thermogenesis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rhamnose monohydrate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: L. monocytogenes 10403S
Concentration: 50 mM
Incubation Time: 30 h
Result: Promoted the growth of L. monocytogenes.
In Vivo

Rhamnose (0.25-1 mg/mL (dissolve in water; 9 weeks; p.o.) or 300 mg/kg (7 days; i.p.)) monohydrate has anti-obesity effects in obese mice through stimulation of adipose dopamine receptors and thermogenesis[3].
Rhamnose (5,-15 mg/kg; i.p.) monohydrate competitively inhibits the toxic effects of BEC on murine sarcoma 180 (S180) and reduces survival in sarcoma-bearing mice[4].
Rhamnose (1-5 g/kg; once daily; 14 days; i.p.) monohydrate has antitumor activity in mice with Ehrlich’s solid tumor[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced obese mice obtained by administering high-fat diet (HFD) to 6-week-old male C57BL/6J mice for a total of 9-10 weeks[3]
Dosage: 0.25, 0.5, 1 mg/mL (dissolve in water) or 300 mg/kg
Administration: Oral gavage (p.o.), 9 weeks; Intraperitoneal injection (i.p.), 7 days
Result: Reduced the total fat content of mice, improved glucose sensitivity, and promoted the expression of thermogenic genes.
Animal Model: Herston White mice injected intraperitoneally with S180 tumor cells, 30 g, aged 8-10 weeks[4]
Dosage: 5, 10, 15 mg/kg
Administration: Intraperitoneal injection (i.p.); the first dose was given 0.5 h after administration of the S180 tumour cells and the remaining three doses were given at daily intervals
Result: Reduced the survival rate of mice in a dose-dependent manner in the presence of BEC.
Animal Model: NMRI female mouse model of subcutaneous inoculation of Ehrlich's solid tumor (SET)[5]
Dosage: 1, 3, 5 g/kg
Administration: Intraperitoneal injection (i.p.); once daily; 14 days
Result: Inhibited tumor growth and prolonged the survival time of mice.
Clinical Trial
Molecular Weight

182.17

Formula

C6H14O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@H]([C@@H]([C@H]([C@H](C)O)O)O)O.O
Structure Classification
Initial Source

Widespread
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (548.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4894 mL 27.4469 mL 54.8938 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (253 KB) HNMR (130 KB) MS (73 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4894 mL 27.4469 mL 54.8938 mL 137.2345 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL 27.4469 mL
10 mM 0.5489 mL 2.7447 mL 5.4894 mL 13.7234 mL
15 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
20 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8617 mL
25 mM 0.2196 mL 1.0979 mL 2.1958 mL 5.4894 mL
30 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
40 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4309 mL
50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.7447 mL
60 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
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Rhamnose monohydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhamnose10030-85-0L-RhamnoseEndogenous MetaboliteMMPInterleukin RelatedPKAMatrix metalloproteinasesILProtein kinase ADeoxysugaranti-aginganti-obesityMMPsInhibitorinhibitorinhibit

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