2. Metabolic Enzyme/Protease Immunology/Inflammation TGF-beta/Smad Stem Cell/Wnt
  3. Endogenous Metabolite MMP Interleukin Related PKA
  4. Rhamnose

Rhamnose  (Synonyms: L-Rhamnose)

Cat. No.: HY-N1420 Purity: ≥98.0%
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Rhamnose (L-Rhamnose) is an orally active deoxysugar that is widely found in plants and bacteria. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models, showing anti-aging effects. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose is also used in cancer research.

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Rhamnose Chemical Structure

Rhamnose Chemical Structure

CAS No. : 3615-41-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 35 In-stock
Solution
10 mM * 1 mL in DMSO USD 35 In-stock
Solid
50 mg USD 32 In-stock
100 mg USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Rhamnose:

Rhamnose Related Antibodies

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PKA PKAR

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Description

Rhamnose (L-Rhamnose) is an orally active deoxysugar that is widely found in plants and bacteria. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models, showing anti-aging effects. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose is also used in cancer research[2][3][5].
IC50 & Target

Microbial Metabolite

 

In Vitro

Rhamnose (50 mM, 30 h) can regulate the expression of Prha target genes in Listeria monocytogenes[1].
Rhamnose (1 mM) can reduce the levels of pro-inflammatory interleukins and matrix metalloproteinases (MMPs) in a human dermal fibroblast (NHDF) skin aging model stimulated by advanced glycation end products (AGEs), thus possessing anti-aging potential[2].
Rhamnose (0-300 μM, 1 h) promotes phosphorylation of PKA substrate and HSL in SVF-derived adipocytes, stimulates PKA signaling and induces thermogenesis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rhamnose Related Antibodies

Cell Proliferation Assay[1].

Cell Line: L. monocytogenes 10403S
Concentration: 50 mM
Incubation Time: 30 h
Result: Promoted the growth of L. monocytogenes.

Western Blot Analysis[3].

Cell Line: SVF-derived adipocytes
Concentration: 0-300 μM
Incubation Time: 1 h
Result: Increased phosphorylation of PKA substrate and HSL in SVF-derived adipocytes in a dose- and time-dependent manner.
In Vivo

Rhamnose (0.25, 0.5, 1 mg/mL (dissolve in water; 9 weeks; p.o.) or 300 mg/kg (7 days; i.p.)) has anti-obesity effects in obese mice through stimulation of adipose dopamine receptors and thermogenesis[3].
Rhamnose (5, 10, 15 mg/kg; i.p.) competitively inhibits the toxic effects of BEC on murine sarcoma 180 (S180) and reduces survival in sarcoma-bearing mice[4].
Rhamnose (1, 3, 5 g/kg; once daily; 14 days; i.p.) has antitumor activity in mice with Ehrlich’s solid tumor[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced obese mice obtained by administering high-fat diet (HFD) to 6-week-old male C57BL/6J mice for a total of 9-10 weeks[3].
Dosage: 0.25, 0.5, 1 mg/mL (dissolve in water) or 300 mg/kg
Administration: Oral gavage (p.o.), 9 weeks; Intraperitoneal injection (i.p.), 7 days
Result: Reduced the total fat content of mice, improved glucose sensitivity, and promoted the expression of thermogenic genes.
Animal Model: Herston White mice injected intraperitoneally with S180 tumor cells, 30 g, aged 8-10 weeks[4].
Dosage: 5, 10, 15 mg/kg
Administration: Intraperitoneal injection (i.p.); the first dose was given 0.5 h after administration of the S180 tumour cells and the remaining three doses were given at daily intervals
Result: Reduced the survival rate of mice in a dose-dependent manner in the presence of BEC.
Animal Model: NMRI female mouse model of subcutaneous inoculation of Ehrlich's solid tumor (SET)[5].
Dosage: 1, 3, 5 g/kg
Administration: Intraperitoneal injection (i.p.); once daily; 14 days
Result: Inhibited tumor growth and prolonged the survival time of mice.
Clinical Trial
Molecular Weight

164.16

Formula

C6H12O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@H]([C@@H]([C@H]([C@H](C)O)O)O)O
Structure Classification
Initial Source

Widespread
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (609.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (609.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0916 mL 30.4581 mL 60.9162 mL
5 mM 1.2183 mL 6.0916 mL 12.1832 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (304.58 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (250 KB) HNMR (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.0916 mL 30.4581 mL 60.9162 mL 152.2904 mL
5 mM 1.2183 mL 6.0916 mL 12.1832 mL 30.4581 mL
10 mM 0.6092 mL 3.0458 mL 6.0916 mL 15.2290 mL
15 mM 0.4061 mL 2.0305 mL 4.0611 mL 10.1527 mL
20 mM 0.3046 mL 1.5229 mL 3.0458 mL 7.6145 mL
25 mM 0.2437 mL 1.2183 mL 2.4366 mL 6.0916 mL
30 mM 0.2031 mL 1.0153 mL 2.0305 mL 5.0763 mL
40 mM 0.1523 mL 0.7615 mL 1.5229 mL 3.8073 mL
50 mM 0.1218 mL 0.6092 mL 1.2183 mL 3.0458 mL
60 mM 0.1015 mL 0.5076 mL 1.0153 mL 2.5382 mL
80 mM 0.0761 mL 0.3807 mL 0.7615 mL 1.9036 mL
100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Rhamnose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhamnose3615-41-6L-RhamnoseEndogenous MetaboliteMMPInterleukin RelatedPKAMatrix metalloproteinasesILProtein kinase ADeoxysugaranti-aginganti-obesityMMPsInhibitorinhibitorinhibit

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